Volume 12 Issue 6
Nov.  2021
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Xiao Li, Xie Lixin, Shi Bingyi. Progress on basic and clinical research of immunology in lung transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 637-642. doi: 10.3969/j.issn.1674-7445.2021.06.001
Citation: Xiao Li, Xie Lixin, Shi Bingyi. Progress on basic and clinical research of immunology in lung transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 637-642. doi: 10.3969/j.issn.1674-7445.2021.06.001
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Progress on basic and clinical research of immunology in lung transplantation

doi: 10.3969/j.issn.1674-7445.2021.06.001

  • Institute of Respiratory and Critical Care Medicine, the 8th Medical Center of Chinese People's Liberation Army General Hospital, Beijing Key Laboratory of Organ Transplantation and Immunology Regulatory, Beijing 100091, China

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  • Corresponding author: Shi Bingyi, Email: shibingyi666@126.com
  • Received Date: 2021-08-03
  • Publish Date: 2021-11-15
    Abstract
  • The quality of life of organ transplant recipients is closely correlated with immune status. Compared with those undergoing other solid organ transplantation, the long-term prognosis of lung transplant recipients is worse. The underlying immune mechanism is complex with both similarities and characteristics. Therefore, in-depth understanding of the immune mechanism in the process of immune response of allogeneic lung transplantation plays a critical role in improving the long-term survival of the recipients. In this article, the unique composition of immune cells in the lung, the characteristics of rejection after lung transplantation, the early warning and differential diagnosis of pathogen infection in lung transplantation and postoperative complications after lung transplantation were investigated. Research progress on clinical diagnosis and basic studies related to immunology in allogeneic lung transplantation were summarized, aiming to elucidate the immunological characteristics of lung transplantation and provide theoretical basis for improving the longterm survival of lung transplant recipients and prevention and treatment of allograft dysfunction.

     

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    • References(31)
  • [1]
    CHAMBERS DC, CHERIKH WS, HARHAY MO, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-sixth adult lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match[J]. J Heart Lung Transplant, 2019, 38(10): 1042- 1055. DOI: 10.1016/j.healun.2019.08.001.
    [2]
    BENZIMRA M, CALLIGARO GL, GLANVILLE AR. Acute rejection[J]. J Thorac Dis, 2017, 9(12): 5440-5457. DOI: 10.21037/jtd.2017.11.83.
    [3]
    LEI YM, CHEN L, WANG Y, et al. The composition of the microbiota modulates allograft rejection[J]. J Clin Invest, 2016, 126(7): 2736-2744. DOI: 10.1172/JCI85295.
    [4]
    白丽, 王佳, 田志刚, 等. 我国在组织器官区域免疫特性与疾病领域的研究进展[J]. 中国科学(生命科学), 2019, 49(3): 220-227. https://www.cnki.com.cn/Article/CJFDTOTAL-JCXK201903003.htm

    BAI L, WANG J, TIAN ZG, et al. Research progress in tissue/organ regional immunity and diseases in China[J]. Sci China Life Sci, 2019, 49(3): 220-227. https://www.cnki.com.cn/Article/CJFDTOTAL-JCXK201903003.htm
    [5]
    BRACIALE TJ, SUN J, KIM TS. Regulating the adaptive immune response to respiratory virus infection[J]. Nat Rev Immunol, 2012, 12(4): 295-305.
    [6]
    洪文娟, 洪志鹏. 肺移植免疫相关的研究进展及展望[J/CD]. 中华肺部疾病杂志(电子版), 2018, 11(5): 519- 523. 10.3877/cma.j.issn.1674-6902.2018.05.001

    HONG WJ, HONG ZP. Progress and prospect of immunological research on lung transplantation[J/CD]. Chin J Lung Dis (Electr Edit), 2018, 11(5): 519-523. 10.3877/cma.j.issn.1674-6902.2018.05.001
    [7]
    HACHEM RR, KHALIFAH AP, CHAKINALA MM, et al. The significance of a single episode of minimal acute rejection after lung transplantation[J]. Transplantation, 2005, 80(10): 1406-1413. DOI: 10.1097/01.tp.0000181161.60638.fa.
    [8]
    ZEPP JA, MORRISEY EE. Cellular crosstalk in the development and regeneration of the respiratory system[J]. Nat Rev Mol Cell Biol, 2019, 20(9): 551-566. DOI: 10.1038/s41580-019-0141-3.
    [9]
    XU X, XU JF, ZHENG G, et al. CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses[J]. Nat Immunol, 2018, 19(6): 547-560. DOI: 10.1038/s41590-018-0112-4.
    [10]
    CAI T, QIU J, JI Y, et al. IL-17-producing ST2+ group 2 innate lymphoid cells play a pathogenic role in lung inflammation[J]. J Allergy Clin Immunol, 2019, 143(1): 229-244. DOI: 10.1016/j.jaci.2018.03.007.
    [11]
    LI W, BRIBRIESCO AC, NAVA RG, et al. Lung transplant acceptance is facilitated by early events in the graft and is associated with lymphoid neogenesis[J]. Mucosal Immunol, 2012, 5(5): 544-554. DOI: 10.1038/mi.2012.30.
    [12]
    YAMADA Y, BRÜSTLE K, JUNGRAITHMAYR W. T helper cell subsets in experimental lung allograft rejection[J]. J Surg Res, 2019, 233: 74-81. DOI: 10.1016/j.jss.2018.07.073.
    [13]
    练巧燕, 陈奥, 徐鑫, 等. 肺移植术后稳定状态受者T淋巴细胞亚群的动态变化分析[J]. 器官移植, 2021, 12(1): 83-89. DOI: 10.3969/j.issn.1674-7445.2021.01.013.

    LIAN QY, CHEN A, XU X, et al. Analysis on dynamic changes of T lymphocyte subsets in recipients with stable graft status after lung transplantation[J]. Organ Transplant, 2021, 12(1): 83-89. DOI: 10.3969/j.issn.1674-7445.2021.01.013.
    [14]
    COIFFARD B, PELARDY M, LOUNDOU AD, et al. Effect of immunosuppression on target blood immune cells within 1 year after lung transplantation: influence of age on T lymphocytes[J]. Ann Transplant, 2018, 23: 11- 24. DOI: 10.12659/aot.906372.
    [15]
    SPECK NE, SCHUURMANS MM, BENDEN C, et al. Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers[J]. Respir Res, 2017, 18(1): 151. DOI: 10.1186/s12931-017-0634-6.
    [16]
    HODGE G, HODGE S, AHERN J, et al. Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome[J]. Clin Exp Immunol, 2013, 173(1): 150-160. DOI: 10.1111/cei.12081.
    [17]
    NOSOTTI M, TARSIA P, MORLACCHI LC. Infections after lung transplantation[J]. J Thorac Dis, 2018, 10(6): 3849-3868. DOI: 10.21037/jtd.2018.05.204.
    [18]
    HOOVER J, MINTZ MA, DEITER F, et al. Rapid molecular detection of airway pathogens in lung transplant recipients[J]. Transpl Infect Dis, 2021, 23(4): e13579. DOI: 10.1111/tid.13579.
    [19]
    PERMPALUNG N, SAIT AS, BAZEMORE K, et al. Human metapneumovirus and parainfluenza virus infections in lung transplant recipients: the effects on lung allograft and clinical outcomes[J]. Transplantation, 2021, DOI: 10.1097/TP.0000000000003645[Epubaheadofprint].
    [20]
    GARDINER BJ, LEE SJ, CRISTIANO Y, et al. Evaluation of Quantiferon®-Monitor as a biomarker of immunosuppression and predictor of infection in lung transplant recipients[J]. Transpl Infect Dis, 2021, 23(3): e13550. DOI: 10.1111/tid.13550.
    [21]
    WU B, HUANG M, JIAO G, et al. Lung transplantation during the outbreak of coronavirus disease 2019 in China[J]. J Thorac Cardiovasc Surg, 2020, DOI: 10.1016/j.jtcvs.2020.10.154[Epubaheadofprint].
    [22]
    HAWKINS RB, MEHAFFEY JH, CHARLES EJ, et al. Lung transplantation for severe post-coronavirus disease 2019 respiratory failure[J]. Transplantation, 2021, 105(6): 1381- 1387. DOI: 10.1097/TP.0000000000003706.
    [23]
    KAUL DR, VALESANO AL, PETRIE JG, et al. Donor to recipient transmission of SARS-CoV-2 by lung transplantation despite negative donor upper respiratory tract testing[J]. Am J Transplant, 2021, 21(8): 2885-2889. DOI: 10.1111/ajt.16532.
    [24]
    LIU M, WORLEY S, MALLORY GB JR, et al. Fungal infections in pediatric lung transplant recipients: colonization and invasive disease[J]. J Heart Lung Transplant, 2009, 28(11): 1226-1230. DOI: 10.1016/j.healun.2009.06.006.
    [25]
    PENNINGTON KM, YOST KJ, ESCALANTE P, et al. Antifungal prophylaxis in lung transplant: a survey of United States' transplant centers[J]. Clin Transplant, 2019, 33(7): e13630. DOI: 10.1111/ctr.13630.
    [26]
    RAMMAERT B, PUYADE M, CORNELY OA, et al. Perspectives on scedosporium species and lomentospora prolificans in lung transplantation: results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology[J]. Transpl Infect Dis, 2019, 21(5): e13141. DOI: 10.1111/tid.13141.
    [27]
    DIAMOND JM, PORTEOUS MK, CANTU E, et al. Elevated plasma angiopoietin-2 levels and primary graft dysfunction after lung transplantation[J]. PLoS One, 2012, 7(12): e51932. DOI: 10.1371/journal.pone.0051932.
    [28]
    MORRISON MI, PITHER TL, FISHER AJ. Pathophysiology and classification of primary graft dysfunction after lung transplantation[J]. J Thorac Dis, 2017, 9(10): 4084-4097. DOI: 10.21037/jtd.2017.09.09.
    [29]
    TESTELMANS D, SCHOOVAERTS K, BELGE C, et al. Sleep-disordered breathing after lung transplantation: an observational cohort study[J]. Am J Transplant, 2021, 21(1): 281-290. DOI: 10.1111/ajt.16130.
    [30]
    崔小川, 李琪, 周敏. 肺移植与阻塞性睡眠呼吸暂停[J]. 中华结核和呼吸杂志, 2021, 44(3): 257-260. DOI: 10.3760/cma.j.cn112147-20200606-00682.

    CUI XC, LI Q, ZHOU M, et al. Progress in the treatment of mycobacterium abscessus pulmonary disease[J]. Chin J Tuberc Respir Dis, 2021, 44(3): 257-260. DOI: 10.3760/cma.j.cn112147-20200606-00682.
    [31]
    RAVICHANDRAN R, BANSAL S, RAHMAN M, et al. The role of donor-derived exosomes in lung allograft rejection[J]. Hum Immunol, 2019, 80(8): 588-594. DOI: 10.1016/j.humimm.2019.03.012.
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