Volume 9 Issue 2
Mar.  2018
Turn off MathJax
Article Contents
Article Navigation >  ORGAN TRANSPLANTATION  > 2018  >  9(2): 147-151
Gong Xueyi, Luo Qijie, He Kun, et al. Characteristics and risk factors analysis of infection after liver transplantation from donor liver of donation after citizen's death[J]. ORGAN TRANSPLANTATION, 2018, 9(2): 147-151. doi: 10.3969/j.issn.1674-7445.2018.02.010
Citation: Gong Xueyi, Luo Qijie, He Kun, et al. Characteristics and risk factors analysis of infection after liver transplantation from donor liver of donation after citizen's death[J]. ORGAN TRANSPLANTATION, 2018, 9(2): 147-151. doi: 10.3969/j.issn.1674-7445.2018.02.010
shu

Characteristics and risk factors analysis of infection after liver transplantation from donor liver of donation after citizen's death

doi: 10.3969/j.issn.1674-7445.2018.02.010

  • First Department of General Surgery, Zhongshan City Hospital, Zhongshan 528400, China

More Information
  • Corresponding author: Hu Zemin, Email: hzm138239331428@163.com
  • Received Date: 2017-12-10
    Available Online: 2021-01-19
  • Publish Date: 2018-03-15
    Abstract
  •   Objective  To investigate the characteristics and risk factors of infection after liver transplantation from donor liver of donation after citizen's death.  Methods  Clinical data of 68 recipients after liver transplantation from donor liver of donation after citizen's death were analyzed retrospectively. The recipients were divided into infection group (33 cases) and non-infection group (35 cases) according to the presence of infection after operation. Major infection characteristics of the 68 recipients after liver transplantation were summarized. Univariate analysis was conducted on the possible risk factors of infection after liver transplantation, and multivariate analysis was further conducted on the risk factors with statistical significance, so as to find out the independent risk factors. In addition, accuracy of predicting infection after liver transplantation was analyzed using receiver operating characteristic (ROC) curves.  Results  Thirtythree recipients were infected after liver transplantation, accounting for 49% of the total recipients with bacterial infection and fungal infection mainly. These recipients mainly presented pulmonary infection and abdominal cavity infection. Univariate analysis results showed that a total of 8 factors contributed to infection after liver transplantation from donor liver of organ donation, including the donors' open injury, recipients' preoperative hemoglobin level, platelet count, ChildPugh classification of liver function, model for end-stage liver disease (MELD) score, intraoperative erythrocyte infusion, gamma-glutamyl transpeptidase (GGT) on day 1 after operation and postoperative stay time of intensive care unit (ICU) (all P < 0.05). Multivariate Logistic regression results analysis showed that preoperative hemoglobin level < 120 g/L and postoperative stay time of ICU >96 h were the independent risk factors of infection after liver transplantation from donor liver of organ donation (both P < 0.05). Analysis results of ROC curves showed that preoperative hemoglobin level < 114 g/L and postoperative stay time of ICU >102 h resulted in higher accuracy for predicting postoperative infection.  Conclusions  Infection after liver transplantation from donation after citizen's death presents high incidence, dominated by bacterial infection and fungal infection in lung and abdominal cavity. Low preoperative hemoglobin level and long postoperative stay time of ICU of recipients can increase the risk of infection after liver transplantation.

     

    • FullText(HTML)
  • loading
    • References(14)
  • [1]
    KIM SI. Bacterial infection after liver transplantation[J]. World J Gastrocnterol, 2014, 20(20): 6211-6220. DOI: 10.3748/wjg.v20.i20.6211.
    [2]
    ROMERO FA, RAZONABLE RR. Infections in liver transplant recipients[J]. World J Hepatol, 2011, 3(4): 83-92. DOI: 10.4254/wjh.v3.i4.83.
    [3]
    HERNANDEZ MDEL P, MARTIN P, SIMKINS J, et al. Infectious complications after liver transplantation[J]. Gastroenterol Hepatol(N Y), 2015, 11(11): 741-753. https://www.ncbi.nlm.nih.gov/pubmed/27134589
    [4]
    SINGH N. Fungal infections in the recipients of solid organ transplantation[J]. Infect Dis Clin North Am, 2003, 17(1): 113-134, viii. doi: 10.1016/S0891-5520(02)00067-3
    [5]
    NAFADY-HEGO H, ELGENDY H, MOGHAZY WE, et al. Pattern of bacterial and fungal infections in the first 3 months after pediatric living donor liver transplantation: an 11-year single-center experience[J]. Liver Transpl, 2011, 17(8): 976-984. DOI: 10.1002/lt.22278.
    [6]
    BRIEGEL J, FORST H, SPILL B, et al. Risk factors for systemic fungal infections in liver transplant recipients[J]. Eur J Clin Microbiol Infect Dis, 1995, 14(5): 375-382. doi: 10.1007/BF02114892
    [7]
    SILVEIRA FP, KUSNE S, AST Infectious Diseases Community of Practice. Candida infections in solid organ transplantation[J]. Am J Transplant, 2013, 13(Suppl 4): 220-227. DOI: 10.1111/ajt.12114.
    [8]
    ESCHENAUER GA, LAM SW, CARVER PL. Antifungal prophylaxis in liver transplant recipients[J]. Liver Transpl, 2009, 15(8):842-858. DOI: 10.1002/lt.21826.
    [9]
    张莹, 韩东冬, 王华光, 等.肝移植患者术后感染相关危险因素分析[J].中华临床感染病杂志, 2016, 9(6): 496-501. DOI: 10.3760/cma.j.issn.1674-2397.2016.06.004.

    ZHANG Y, HAN DD, WANG HG, et al. Analysis on risk factors of postoperative infection in liver transplantation patients[J]. Chin J Clin Infect Dis, 2016, 9(6): 496-501. DOI: 10.3760/cma.j.issn.1674-2397.2016.06.004.
    [10]
    李明霞, 彭贵主, 王忍, 等.肝移植术后感染研究进展[J].中华肝胆外科杂志, 2015, 21(7): 494-497. DOI: 10.3760/cma.j.issn.1007-8118.2015.07.018.

    LI MX, PENG GZ, WANG R, et al. Research progress on infections after liver transplantation[J]. Chin J Hepatobiliary Surg, 2015, 21(7): 494-497. DOI: 10.3760/cma.j.issn.1007-8118.2015.07.018.
    [11]
    潘娜, 李素英, 黄晶, 等.肝移植患者术后早期感染菌群分布及耐药性分析[J].北京医学, 2015, 37(12): 1212-1213. DOI: 10.15932/j.0253-9713.2015.12.031.

    PAN N, LI SY, HUANG J, et al. Analysis on bacterial distribution and drug resistance in early stage after liver transplantation[J]. Beijing Med J, 2015, 37(12): 1212-1213. DOI: 10.15932/j.0253-9713.2015.12.031.
    [12]
    SGANGA G, BIANCO G, FIORI B, et al. Surveillance of bacterial and fungal infections in the postoperative period following liver transplantation: a series from 2005-2011[J]. Transplant Proc, 2013, 45(7): 2718-2721. DOI: 10.1016/j.transproceed.2013.08.010.
    [13]
    郑树森.肝移植[M].北京:人民卫生出版社, 2012:606-607.
    [14]
    LEVESQUE E, EL ANBASSI S, SITTERLE E, et al. Contribution of (1, 3)-beta-D-glucan to diagnosis of invasive candidiasis after liver transplantation[J]. J Clin Microbiol, 2015, 53(3): 771-776. DOI: 10.1128/JCM.03018-14.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (163) PDF downloads(11) Cited by()
    Proportional views
    Related

    WeChat Subscription Account

    Wechat Service Account

    Contact Us
    • Tel：020-38736410
    • Email: organtranspl@163.com
    • Address：The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou
    • Editorial Office of Organ Transplantation  粤ICP备2021030844号
    Links

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return