Volume 9 Issue 2
Mar.  2018
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Wang Wanli, Li Qingshan, Zhou Ying, et al. Analysis of risk factors of early acute kidney injury after liver transplantation from DCD donor liver[J]. ORGAN TRANSPLANTATION, 2018, 9(2): 130-136. doi: 10.3969/j.issn.1674-7445.2018.02.007
Citation: Wang Wanli, Li Qingshan, Zhou Ying, et al. Analysis of risk factors of early acute kidney injury after liver transplantation from DCD donor liver[J]. ORGAN TRANSPLANTATION, 2018, 9(2): 130-136. doi: 10.3969/j.issn.1674-7445.2018.02.007
shu

Analysis of risk factors of early acute kidney injury after liver transplantation from DCD donor liver

doi: 10.3969/j.issn.1674-7445.2018.02.007

  • Department of Hepatobiliary Surgery, Liver Transplantation Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

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  • Corresponding author: Wang Bo, Email:bobwang75@126.com
  • Received Date: 2017-12-16
    Available Online: 2021-01-19
  • Publish Date: 2018-03-15
    Abstract
  •   Objective  To analyze the risk factors of early acute kidney injury (AKI) after liver transplantation from donation after cardiac death(DCD) donor liver.  Methods  Clinical data of 184 donors and recipients undergoing liver transplantation from DCD donor liver were retrospectively analyzed. According to the incidence of early AKI, all participants were divided into the AKI and non-AKI groups. The patients in the AKI group were subject to AKI staging. Baseline data, preoperative, intraoperative and postoperative related parameters were statistically compared between two groups. The cumulative survival rate and clinical prognosis of patients in non-AKI group and AKI group with different staging were statistically analyzed by Kaplan-Meier curve analysis.  Results  Among 184 patients, 68 cases (37.0%) presented with early AKI after liver transplantation including 31 stage 1 AKI, 26 stage 2 AKI and 11 stage 3 AKI, mainly occurring within postoperative 3 d. Univariate analysis revealed that preoperative levels of albumin < 35 g/L, preoperative levels of serum sodium ≤137 mmol/L, operation time>7.5 h, intraoperative hemorrhage volume>3 000 mL, intraoperative red cell infusion volume>15 U and intraoperative urine amount ≤100 mL/h were the risk factors of early AKI after liver transplantation (all P < 0.05). Multi-variate Logistic regression analysis demonstrated that intraoperative red cell infusion > 15 U was an independent risk factor of early AKI after liver transplantation [odds ratio(OR) 1.061, 95% confidence interval(CI) 1.008-1.118, P=0.024]. Result of Kaplan-Meier survival curve suggested that the cumulative survival rate was gradually reduced along with the aggravation of AKI with statistical significance (all P < 0.05).  Conclusions  The incidence of early AKI following liver transplantation is relatively high. The severity of early AKI is intimately correlated with the short-and long-term prognosis of the recipients. A large quantity of intraoperative red blood cell infusion is an independent risk factor of AKI.

     

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