Volume 8 Issue 5
Sep.  2017
Turn off MathJax
Article Contents
Article Navigation >  ORGAN TRANSPLANTATION  > 2017  >  8(5): 344-348
Wang Zhe, Chen Manying, Lin Huiqing, et al. Training and evaluation of donor lung procurement technique in swine models[J]. ORGAN TRANSPLANTATION, 2017, 8(5): 344-348. doi: 10.3969/j.issn.1674-7445.2017.05.002
Citation: Wang Zhe, Chen Manying, Lin Huiqing, et al. Training and evaluation of donor lung procurement technique in swine models[J]. ORGAN TRANSPLANTATION, 2017, 8(5): 344-348. doi: 10.3969/j.issn.1674-7445.2017.05.002
shu

Training and evaluation of donor lung procurement technique in swine models

doi: 10.3969/j.issn.1674-7445.2017.05.002

  • Department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710082, China

More Information
    Abstract
  •   Objective  To investigate the training methods and evaluation parameters for donor lung procurement technique in swine models.  Methods  The surgical skills of donor lung procurement in 15 swine models were summarized. The operation time, objective evaluation parameters before lung perfusion, gross observation after lung perfusion, the type and frequency of intraoperative errors were assessed.  Results  All donor lung procurement surgeries were successfully completed in 15 swine models. The mean time interval from skin incision to lung perfusion was 22.6 min. Prior to lung perfusion, the oxygenation index of the donor lung was (501±68) mmHg, (404±100) mL (under the pressure of 15 mmHg) for the tidal volume and (29±4) mL/cmH2O for the static compliance. Along with the increasing surgical frequency, the oxygenation index and tidal volume were improved. Favorable lung inflation was obtained after lung perfusion in a majority of swine models. Intraoperatively, multiple operating errors occurred including dissection error, pulmonary arterial intubation error and procedure error, etc. As the frequency of operation increased, the frequency of surgical errors was significantly decreased.  Conclusions  After certain training for donor lung procurement in swine models, the incidence of intraoperative procedure error is significantly reduced and the quality of the donor lung tends to be enhanced. Objective parameters, such as oxygenation index and the gross shape of the donor lung can be utilized to evaluate the levels of surgical techniques.

     

    • FullText(HTML)
  • loading
    • References(17)
  • [1]
    Cypel M, Levvey B, Van Raemdonck D, et al. International society for heart and lung transplantation donation after circulatory death registry report[J]. J Heart Lung Transplant, 2015, 34(10): 1278-1282. DOI: 10.1016/j.healun.2015.08.015.
    [2]
    Lund LH, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: thirty-second official adult heart transplantation report--2015; focus theme: early graft failure[J]. J Heart Lung Transplant, 2015, 34(10): 1244-1254. DOI: 10.1016/j.healun.2015.08.003.
    [3]
    Tikkanen JM, Cypel M, Machuca TN, et al. Functional outcomes and quality of life after normothermic ex vivo lung perfusion lung transplantation[J]. J Heart Lung Transplant, 2015, 34(4): 547-556. DOI: 10.1016/j.healun.2014.09.044.
    [4]
    Solomon M, Grasemann H, Keshavjee S. Pediatric lung transplantation[J]. Pediatr Clin North Am, 2010, 57(2): 375-391. DOI: 10.1016/j.pcl.2010.01.017.
    [5]
    Reeb J, Keshavjee S, Cypel M. Expanding the lung donor pool: advancements and emerging pathways[J]. Curr Opin Organ Transplant, 2015, 20(5): 498-505. DOI: 10.1097/MOT.0000000000000233.
    [6]
    Yeung JC, Keshavjee S. Overview of clinical lung transplantation[J]. Cold Spring Harb Perspect Med, 2014, 4(1): a015628. DOI: 10.1101/cshperspect.a015628.
    [7]
    Hernadez-Alejandro R, Wall W, Jevnikar A, et al. Organ donation after cardiac death: donor and recipient outcomes after the first three years of the ontario experience[J]. Can J Anaesth, 2011, 58(7): 599-605. DOI: 10.1007/s12630-011-9511-9.
    [8]
    毛文君, 陈静瑜, 中国肺移植面临的困难及对策[J/CD]. 中华胸部外科电子杂志, 2016, 3(1): 1-6. DOI: 10.3877/cma.j.issn.2095-8773.2016.01.001.

    Mao WJ, Chen JY. Difficulties and countermeasures of lung transplantation in China[J/CD]. Chin J Thoracic Surg (Electr Edit), 2016, 3(1): 1-6. DOI: 10.3877/cma.j.issn.2095-8773.2016.01.001.
    [9]
    Cypel M, Sato M, Yildirim E, et al. Initial experience with lung donation after cardiocirculatory death in Canada[J]. J Heart Lung Transplant, 2009, 28(8): 753-758. DOI: 10.1016/j.healun.2009.05.009.
    [10]
    Manara AR, Murphy PG, O'Callaghan G. Donation after circulatory death[J]. Br J Anaesth, 2012, 108(Suppl 1):i108-i121. DOI: 10.1093/bja/aer357.
    [11]
    Snell GI, Levvey BJ, Oto T, et al. Early lung transplantation success utilizing controlled donation after cardiac death donors[J]. Am J Transplant, 2008, 8(6): 1282-1289. DOI: 10.1111/j.1600-6143.2008.02231.x.
    [12]
    Saxena P, Zimmet AD, Snell G, et al. Procurement of lungs for transplantation following donation after circulatory death: the Alfred technique[J]. J Surg Res, 2014, 192(2): 642-646. DOI: 10.1016/j.jss.2014.07.063.
    [13]
    Pasque MK. Standardizing thoracic organ procurement for transplantation[J]. J Thorac Cardiovasc Surg, 2010, 139(1): 13-17. DOI: 10.1016/j.jtcvs.2009.09.015.
    [14]
    Sundaresan S, Trachiotis GD, Aoe M, et al. Donor lung procurement: assessment and operative technique[J]. Ann Thorac Surg, 1993, 56(6): 1409-1413. doi: 10.1016/0003-4975(93)90699-I
    [15]
    Veith FJ, Sinha SB, Graves JS, et al. Ischemic tolerance of the lung. the effect of ventilation and inflation[J]. J Thorac Cardiovasc Surg, 1971, 61(5):804-810.
    [16]
    Badellino MM, Morganroth ML, Grum CM, et al. Hypothermia or continuous ventilation decreases ischemia-reperfusion injury in an ex vivo ratlung model[J]. Surgery, 1989, 105(6): 752-760. https://experts.umich.edu/en/publications/hypothermia-or-continuous-ventilation-decreases-ischemia-reperfus
    [17]
    Pierre L, Lindstedt S, Ingemansson R. Ventilation in situ after cardiac death improves pulmonary grafts exposed to 2 hours of warmischemia[J]. Scand Cardiovasc J, 2015, 49(5): 293-298. DOI: 10.3109/14017431.2015.1052549.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(5)  / Tables(1)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (108) PDF downloads(8) Cited by()
    Proportional views
    Related

    WeChat Subscription Account

    Wechat Service Account

    Contact Us
    • Tel：020-38736410
    • Email: organtranspl@163.com
    • Address：The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou
    • Editorial Office of Organ Transplantation  粤ICP备2021030844号
    Links

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return