[1] |
Kim WR, Lake JR, Smith JM, et al. OPTN/SRTR 2015 annual data report: liver[J]. Am J Transplant, 2017, 17 (Suppl 1): 174-251. DOI: 10.1111/ajt.14126.
|
[2] |
Wang Y, Nicolas CT, Chen HS, et al. Recent advances in decellularization and recellularization for tissue-engineered liver grafts[J]. Cells Tissues Organs, 2017, 203(4): 203-214. DOI: 10.1159/000452761.
|
[3] |
Caralt M. Present and future of regenerative medicine: liver transplantation[J]. Transplant Proc, 2015, 47(8): 2377-2379. DOI: 10.1016/j.transproceed.2015.08.029.
|
[4] |
Mazza G, Rombouts K, Rennie Hall A, et al. Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation[J]. Sci Rep, 2015, 5: 13079. DOI: 10.1038/srep13079.
|
[5] |
Baptista PM, Siddiqui MM, Lozier G, et al. The use of whole organ decellularization for the generation of a vascularized liver organoid[J]. Hepatology, 2011, 53(2): 604-617. DOI: 10.1002/hep.24067.
|
[6] |
Hassanein W, Uluer MC, Langford J, et al. Recellularization via the bile duct supports functional allogenic and xenogenic cell growth on a decellularized rat liver scaffold[J]. Organogenesis, 2017, 13(1): 16-27. DOI: 10.1080/15476278.2016.1276146.
|
[7] |
Ko IK, Peng L, Peloso A, et al. Bioengineered transplantable porcine livers with re-endothelialized vasculature[J]. Biomaterials, 2015, 40: 72-79. DOI: 10.1016/j.biomaterials.2014.11.027.
|
[8] |
Soto-Gutierrez A, Zhang L, Medberry C, et al. A whole-organ regenerative medicine approach for liver replacement[J]. Tissue Eng Part C Methods, 2011, 17(6): 677-686. DOI: 10.1089/ten.tec.2010.0698.
|
[9] |
Uygun BE, Soto-Gutierrez A, Yagi H, et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix[J]. Nat Med, 2010, 16(7): 814-820. DOI: 10.1038/nm.2170.
|
[10] |
Yagi H, Fukumitsu K, Fukuda K, et al. Human-scale whole-organ bioengineering for liver transplantation: a regenerative medicine approach[J]. Cell Transplant, 2013, 22(2): 231-242. DOI: 10.3727/096368912X654939.
|
[11] |
Lin P, Chan WC, Badylak SF, et al. Assessing porcine liver-derived biomatrix for hepatic tissue engineering[J]. Tissue Eng, 2004, 10(7/8): 1046-1053. DOI: 10.1089/ten.2004.10.1046
|
[12] |
Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes[J]. Biomaterials, 2011, 32(12): 3233-3243. DOI: 10.1016/j.biomaterials.2011.01.057.
|
[13] |
Conklin BS, Wu H, Lin PH, et al. Basic fibroblast growth factor coating and endothelial cell seeding of a decellularized heparin-coated vascular graft[J]. Artif Organs, 2004, 28(7): 668-675. DOI: 10.1111/j.1525-1594.2004.00062.x.
|
[14] |
Nakamura S, Ijima H. Solubilized matrix derived from decellularized liver as a growth factor-immobilizable scaffold for hepatocyte culture[J]. J Biosci Bioeng, 2013, 116(6): 746-753. DOI: 10.1016/j.jbiosc.2013.05.031.
|
[15] |
Uygun BE, Yarmush ML, Uygun K. Application of whole-organ tissue engineering in hepatology[J]. Nat Rev Gastroenterol Hepatol, 2012, 9(12): 738-744. DOI: 10.1038/nrgastro.2012.140.
|
[16] |
Verhulsel M, Vignes M, Descroix S, et al. A review of microfabrication and hydrogel engineering for micro-organs on chips[J]. Biomaterials, 2014, 35(6): 1816-1832. DOI: 10.1016/j.biomaterials.2013.11.021.
|
[17] |
Yamada M, Utoh R, Ohashi K, et al. Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions[J]. Biomaterials, 2012, 33(33):8304-8315. DOI: 10.1016/j.biomaterials.2012.07.068.
|
[18] |
Rennert K, Steinborn S, Gröger M, et al. A microfluidically perfused three dimensional human liver model[J]. Biomaterials, 2015, 71:119-131. DOI: 10.1016/j.biomaterials.2015.08.043.
|
[19] |
Chen AA, Thomas DK, Ong LL, et al. Humanized mice with ectopic artificial liver tissues[J]. Proc Natl Acad Sci USA, 2011, 108(29): 11842-11847. DOI: 10.1073/pnas.1101791108.
|
[20] |
Stevens KR, Scull MA, Ramanan V, et al. In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease[J]. Sci Transl Med, 2017, 9(399): eaah5505. DOI: 10.1126/scitranslmed.aah5505.
|
[21] |
Coghlan A. 3D printer makes tiniest human liver ever[EB/OL]. (2013-04-23). https://www.newscientist.com/article/dn23419-3d-printer-makes-tiniest-human-liver-ever.html.
|
[22] |
Sasai Y. Next-generation regenerative medicine: organogenesis from stem cells in 3D culture[J]. Cell Stem Cell, 2013, 12(5): 520-530. DOI: 10.1016/j.stem.2013.04.009.
|
[23] |
Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors[J]. Cell, 2007, 131(5): 861-872. DOI: 10.1016/j.cell.2007.11.019.
|
[24] |
Matsumoto K, Yoshitomi H, Rossant J, et al. Liver organogenesis promoted by endothelial cells prior to vascular function[J]. Science, 2001, 294(5542): 559-563. DOI: 10.1126/science.1063889.
|
[25] |
Korzh S, Pan X, Garcia-Lecea M, et al. Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish[J]. BMC Dev Biol, 2008, 8:84. DOI: 10.1186/1471-213X-8-84.
|
[26] |
Takebe T, Sekine K, Enomura M, et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant[J]. Nature, 2013, 499(7459): 481-484. DOI: 10.1038/nature12271.
|
[27] |
Takebe T, Enomura M, Yoshizawa E, et al. Vascularized and complex organ buds from diverse tissues via mesenchymal cell-driven condensation[J]. Cell Stem Cell, 2015, 16(5): 556-565. DOI: 10.1016/j.stem.2015.03.004.
|
[28] |
Guye P, Ebrahimkhani MR, Kipniss N, et al. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using GATA6[J]. Nat Commun, 2016, 7:10243. DOI: 10.1038/ncomms10243.
|
[29] |
Ozair MZ, Noggle S, Warmflash A, et al. SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism[J]. Stem Cells, 2013, 31(1): 35-47. DOI: 10.1002/stem.1246.
|
[30] |
Peterkin T, Gibson A, Patient R. GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation[J]. EMBO J, 2003, 22(16): 4260-4273. DOI: 10.1093/emboj/cdg400.
|
[31] |
Rhim JA, Sandgren EP, Palmiter RD, et al. Complete reconstitution of mouse liver with xenogeneic hepatocytes[J]. Proc Natl Acad Sci USA, 1995, 92(11): 4942-4946. doi: 10.1073/pnas.92.11.4942
|
[32] |
Dandri M, Burda MR, Török E, et al. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus[J]. Hepatology, 2001, 33(4): 981-988. DOI: 10.1053/jhep.2001.23314.
|
[33] |
Tateno C, Yoshizane Y, Saito N, et al. Near completely humanized liver in mice shows human-type metabolic responses to drugs[J]. Am J Pathol, 2004, 165(3): 901-912. DOI: 10.1016/S0002-9440(10)63352-4.
|
[34] |
Meuleman P, Libbrecht L, De Vos R, et al. Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera[J]. Hepatology, 2005, 41(4): 847-856. DOI: 10.1002/hep.20657.
|
[35] |
Azuma H, Paulk N, Ranade A, et al. Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/-mice[J]. Nat Biotechnol, 2007, 25(8): 903-910. DOI: 10.1038/nbt1326.
|
[36] |
Bissig KD, Le TT, Woods NB, et al. Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model[J]. Proc Natl Acad Sci USA, 2007, 104(51): 20507-20511. DOI: 10.1073/pnas.0710528105.
|
[37] |
Rashid T, Kobayashi T, Nakauchi H. Revisiting the flight of icarus: making human organs from PSCs with large animal chimeras[J]. Cell Stem Cell, 2014, 15(4): 406-409. DOI: 10.1016/j.stem.2014.09.013.
|
[38] |
Kim H, Kim JS. A guide to genome engineering with programmable nucleases[J]. Nat Rev Genet, 2014, 15(5): 321-334. DOI: 10.1038/nrg3686.
|
[39] |
Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering[J]. Cell, 2014, 157(6): 1262-1278. DOI: 10.1016/j.cell.2014.05.010.
|
[40] |
Yang L, Güell M, Niu D, et al. Genome-wide inactivation of porcine endogenous retroviruses (PERVs)[J]. Science, 2015, 350(6264): 1101-1104. DOI: 10.1126/science.aad1191.
|
[41] |
Cooper DK, Ekser B, Ramsoondar J, et al. The role of genetically engineered pigs in xenotransplantation research[J]. J Pathol, 2016, 238(2): 288-299. DOI: 10.1002/path.4635.
|
[42] |
Shaw D, Dondorp W, Geijsen N, et al. Creating human organs in chimaera pigs: an ethical source of immunocompatible organs?[J]. J Med Ethics, 2015, 41(12): 970-974. DOI: 10.1136/medethics-2014-102224.
|
[43] |
Wu J, Platero-Luengo A, Sakurai M, et al. Interspecies chimerism with mammalian pluripotent stem cells[J]. Cell, 2017, 168(3): 473-486. DOI: 10.1016/j.cell.2016.12.036.
|
[44] |
Xiang AP, Mao FF, Li WQ, et al. Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host[J]. Hum Mol Genet, 2008, 17(1): 27-37. DOI: 10.1093/hmg/ddm282.
|
[45] |
Li W, Huang L, Lin W, et al. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells[J]. Biomaterials, 2015, 39: 75-84. DOI: 10.1016/j.biomaterials.2014.10.056.
|