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肾移植受者免疫抑制方案的优化

董震, 王洪阳. 肾移植受者免疫抑制方案的优化[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2024087
引用本文: 董震, 王洪阳. 肾移植受者免疫抑制方案的优化[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2024087
Dong Zhen, Wang Hongyang. Optimization of immunosuppressive regimen for kidney transplant recipients[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024087
Citation: Dong Zhen, Wang Hongyang. Optimization of immunosuppressive regimen for kidney transplant recipients[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024087

肾移植受者免疫抑制方案的优化

doi: 10.3969/j.issn.1674-7445.2024087
基金项目: 山东省自然科学基金青年项目(ZR2020QH237);青岛大学附属医院青年科学基金(QDFYQN2023120)
详细信息
    通讯作者:

    董震(ORCID 0009-000-2445-7748),Email: dong266000@163.com

  • 中图分类号: R617,R392.4

Optimization of immunosuppressive regimen for kidney transplant recipients

More Information
  • 摘要: 随着手术技术的成熟与发展,以及围手术期管理水平的提高,肾移植手术成功率显著提高。但由于供受者在遗传性与抗原性上存在的明显差异,会导致肾移植术后发生排斥反应,影响移植物的存活。免疫抑制是治疗排斥反应的重要手段,对减少排斥反应发生,提高移植物存活率具有重要意义。但免疫抑制药在减少排斥反应的同时会引起感染、心血管疾病、肿瘤等并发症,严重影响患者的生活质量,甚至可能导致患者死亡。合理地选择免疫抑制药,不断优化受者免疫抑制方案,对改善受者和移植肾的存活具有重要意义。因此,本文就器官移植发展史、免疫诱导治疗、免疫维持治疗进行评述,探讨肾移植受者免疫抑制方案优化取得的进展,以期为改善肾移植预后提供参考。

     

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  • 收稿日期:  2024-03-05
  • 网络出版日期:  2024-04-29

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