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异种移植排斥反应及其预防治疗策略

何小舟, 付嘉钊, 周萃星. 异种移植排斥反应及其预防治疗策略[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2024079
引用本文: 何小舟, 付嘉钊, 周萃星. 异种移植排斥反应及其预防治疗策略[J]. 器官移植. doi: 10.3969/j.issn.1674-7445.2024079
He Xiaozhou, Fu Jiazhao, Zhou Cuixing. Xenotransplantation rejection and preventive and therapeutic strategies[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024079
Citation: He Xiaozhou, Fu Jiazhao, Zhou Cuixing. Xenotransplantation rejection and preventive and therapeutic strategies[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024079

异种移植排斥反应及其预防治疗策略

doi: 10.3969/j.issn.1674-7445.2024079
基金项目: 江苏省自然科学基金(BK20211064)
详细信息
    作者简介:
    通讯作者:

    何小舟(ORCID 0000-0002-7969-7386),Email:hyx@suda.edu.cn

  • 中图分类号: R617, Q78

Xenotransplantation rejection and preventive and therapeutic strategies

More Information
  • 摘要: 异种移植是解决人类器官短缺问题的潜在方案。在过去的上百年里,异种移植经历了早期尝试和不断进步,目前已进入新的高速发展阶段,取得了一系列的成果,但异种移植排斥反应的管理较同种异体器官移植排斥反应更为棘手。为此,研究者们开发出了一系列免疫抑制策略,如使用基因修饰猪供体、使用传统和新型免疫抑制药、将供体猪的胸腺与供器官一同移植等,以实现调整受体免疫系统反应,降低排斥反应强度并延长移植物存活时间。本文就异种移植排斥反应发生机制、预防和治疗策略的相关研究进行评述,以期为促进异种移植的进一步发展提供参考。

     

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  • 收稿日期:  2024-04-26
  • 网络出版日期:  2024-07-08

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