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肝移植受者雷帕霉素靶蛋白抑制剂临床应用中国专家共识(2023版)

霍枫, 徐骁, 叶啟发, 等. 肝移植受者雷帕霉素靶蛋白抑制剂临床应用中国专家共识(2023版)[J]. 器官移植, 2023, 14(6): 765-780. doi: 10.3969/j.issn.1674-7445.2023167
引用本文: 霍枫, 徐骁, 叶啟发, 等. 肝移植受者雷帕霉素靶蛋白抑制剂临床应用中国专家共识(2023版)[J]. 器官移植, 2023, 14(6): 765-780. doi: 10.3969/j.issn.1674-7445.2023167
Huo Feng, Xu Xiao, Ye Qifa, et al. Chinese expert consensus on clinical application of inhibitors of mammalian target of rapamycin in liver transplant recipients (2023 edition)[J]. ORGAN TRANSPLANTATION, 2023, 14(6): 765-780. doi: 10.3969/j.issn.1674-7445.2023167
Citation: Huo Feng, Xu Xiao, Ye Qifa, et al. Chinese expert consensus on clinical application of inhibitors of mammalian target of rapamycin in liver transplant recipients (2023 edition)[J]. ORGAN TRANSPLANTATION, 2023, 14(6): 765-780. doi: 10.3969/j.issn.1674-7445.2023167

肝移植受者雷帕霉素靶蛋白抑制剂临床应用中国专家共识(2023版)

doi: 10.3969/j.issn.1674-7445.2023167
基金项目: 中国器官移植发展基金会器官移植受者健康管理专项基金(COTDF-020004)
详细信息
    通讯作者:

    霍枫(510010 广州,中国人民解放军南部战区总医院,Email: gzhuofeng@163.com

    徐骁(310003 杭州,浙江大学医学院,Email: zjxu@zju.edu.cn

    叶啟发(430026 武汉,武汉大学中南医院,Email: yqf_china@163.com

    薛武军(710061 西安,西安交通大学第一附属医院,Email: xwujun126@xjtu.edu.cn

  • 中图分类号: R617, R979.5

Chinese expert consensus on clinical application of inhibitors of mammalian target of rapamycin in liver transplant recipients (2023 edition)

More Information
    Corresponding author: Huo Feng, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China, Email: gzhuofeng@163.com Xu Xiao, Zhejiang University School of Medcine, Hangzhou 310003, China, Email: zjxu@zju.edu.cnYe Qifa, Zhongnan Hospital of Wuhan University, Wuhan 430026, China, Email: yqf_china@163.comXue Wujun, First Affiliated Hospital of Xi′an Jiaotong University, Xi′an 710061, China, Email: xwujun126@xjtu.edu.cn
  • 摘要: 肝移植受者的长期存活和生存质量很大程度上取决于术后中长期健康管理和免疫抑制方案。长期服用免疫抑制剂可导致受者出现肾损伤、代谢性疾病和新发恶性肿瘤等严重并发症,甚至增加肝癌肝移植术后肿瘤复发风险。目前肝移植受者常用的免疫抑制方案以钙调磷酸酶抑制剂(CNI)为基础,但是CNI引起的肾脏毒性、神经毒性和促进肿瘤复发等问题极大地影响了受者预后,近年来临床逐渐减少其用量并寻求替代药物。近年来使用以哺乳动物雷帕霉素靶蛋白抑制剂(mTORi)为基础的免疫抑制方案逐渐增多,国内外多部指南均对肝移植受者使用mTORi给出了指导意见。为了更好地为国内肝移植临床医师提供参考,中国器官移植发展基金会组织国内经验丰富的移植专家,结合已发表的国内外指南、共识和研究进展,经广泛征求意见,共同制订本专家共识。

     

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  • 收稿日期:  2023-07-03
  • 录用日期:  2023-09-22
  • 网络出版日期:  2023-09-27
  • 刊出日期:  2023-11-09

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