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肝移植治疗肝内胆管癌的研究进展

汪国营, 何才华. 肝移植治疗肝内胆管癌的研究进展[J]. 器官移植, 2023, 14(6): 789-796. doi: 10.3969/j.issn.1674-7445.2023144
引用本文: 汪国营, 何才华. 肝移植治疗肝内胆管癌的研究进展[J]. 器官移植, 2023, 14(6): 789-796. doi: 10.3969/j.issn.1674-7445.2023144
Wang Guoying, He Caihua. Progress in liver transplantation for intrahepatic cholangiocarcinoma[J]. ORGAN TRANSPLANTATION, 2023, 14(6): 789-796. doi: 10.3969/j.issn.1674-7445.2023144
Citation: Wang Guoying, He Caihua. Progress in liver transplantation for intrahepatic cholangiocarcinoma[J]. ORGAN TRANSPLANTATION, 2023, 14(6): 789-796. doi: 10.3969/j.issn.1674-7445.2023144

肝移植治疗肝内胆管癌的研究进展

doi: 10.3969/j.issn.1674-7445.2023144
基金项目: 广东省自然科学基金面上项目(2022A1515010519);广州市基础研究计划市校(院)联合资助项目(202201020439);广州市临床特色技术项目(2023C-TS18)
详细信息
    通讯作者:

    汪国营(ORCID: 0000-0002-0304-0986),Email:wanggy3@126.com

  • 中图分类号: R617, R735.7

Progress in liver transplantation for intrahepatic cholangiocarcinoma

More Information
  • 摘要: 肝内胆管癌(ICC)是仅次于肝细胞癌的肝脏原发性恶性肿瘤,其发病率在全球范围内呈上升趋势。肝切除术一直是ICC患者外科治疗的首选,而ICC过去由于高肿瘤复发率和较差的生存结果,被视为肝移植禁忌证。目前,ICC肝移植治疗已经取得了诸多重要进展,对于严格筛选的ICC患者,肝移植或在新辅助治疗后肝移植取得了令人鼓舞的生存结果。同时,随着ICC肝移植治疗预后风险分层的完善,也将进一步优化ICC肝移植候选者的选择标准。此外,ICC现代多模式综合治疗的发展,也将进一步指导ICC肝移植术前新辅助治疗方案的选择。ICC肝移植前应用免疫检查点抑制剂也是未来重要的研究方向。本文从ICC肝移植治疗的预后、ICC肝移植的预后风险因素及候选者选择标准、正在进行的试验和挑战进行总结,以期为肝移植治疗ICC提供参考,提高ICC患者的生存质量。

     

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出版历程
  • 收稿日期:  2023-07-22
  • 网络出版日期:  2023-08-25
  • 刊出日期:  2023-11-09

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