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巨噬细胞与肾移植

郑龙, 蔡明. 巨噬细胞与肾移植[J]. 器官移植, 2023, 14(5): 643-648. doi: 10.3969/j.issn.1674-7445.2023139
引用本文: 郑龙, 蔡明. 巨噬细胞与肾移植[J]. 器官移植, 2023, 14(5): 643-648. doi: 10.3969/j.issn.1674-7445.2023139
Zheng Long, Cai Ming. Macrophages and kidney transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 643-648. doi: 10.3969/j.issn.1674-7445.2023139
Citation: Zheng Long, Cai Ming. Macrophages and kidney transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 643-648. doi: 10.3969/j.issn.1674-7445.2023139

巨噬细胞与肾移植

doi: 10.3969/j.issn.1674-7445.2023139
基金项目: 浙江省重点研发计划(2022C03127);浙江大学医学院附属第二医院种子基金(ZZ98972022)
详细信息
    作者简介:
    通讯作者:

    蔡明(ORCID:0009-0008-7187-8490),Email:caiming@zju.edu.cn

  • 中图分类号: R617, R392.12

Macrophages and kidney transplantation

More Information
  • 摘要: 肾移植是终末期肾病患者的最佳治疗方案,但移植肾远期存活仍是临床上面临的重要难题。肾缺血-再灌注损伤(IRI)和移植肾排斥反应被认为是影响移植肾远期存活的重要因素,受固有免疫和适应性免疫细胞调控。巨噬细胞是固有免疫细胞中一种,可协助启动适应性免疫,分为M1型巨噬细胞、M2型巨噬细胞和调节性巨噬细胞。先前研究揭示M1型巨噬细胞加重肾IRI和急性T细胞介导的排斥反应(TCMR);而M2型巨噬细胞减轻肾IRI和急性TCMR,但与抗体介导的排斥反应(AMR)呈正相关;调节性巨噬细胞是巨噬细胞一种特殊亚群,可诱导移植免疫耐受,具有极大临床应用前景和基础科研价值。本文述评了巨噬细胞分型、巨噬细胞与肾IRI、移植肾排斥反应及调节性巨噬细胞与免疫耐受的关系,并分析了其可能作用机制,以期诱导巨噬细胞亚型改变或清除特定亚型巨噬细胞,进而改善移植预后及移植肾远期存活。

     

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出版历程
  • 收稿日期:  2023-07-17
  • 录用日期:  2023-07-21
  • 网络出版日期:  2023-09-08
  • 刊出日期:  2023-09-15

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