In vivo transplantation of eye organoids and application of tissue engineering scaffolds
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摘要: 眼类器官是指在体外利用干细胞诱导形成的一种与眼内组织具有相似细胞类型和功能的结构，将其移植入体内实现眼的修复再生是再生医学重点研究方向之一，也为重大致盲性眼病的治疗提供了新的方向与策略。组织工程支架作为生物组织或细胞生长的载体，能为眼类器官的体内移植提供支撑，并促进其体内成熟。眼类器官与组织工程的有机结合是实现眼类器官体内整合，并重建相应结构和功能的重要手段。本综述总结了眼类器官及其体内移植的研究现状，并重点关注了组织工程支架辅助的眼类器官移植相关研究，旨在为今后的眼类器官与组织工程学交叉研究提供思路与参考。Abstract: Eye organoid refers to a structure that possesses resembling cell types and functions to intraocular tissues, which is induced by stem cells in vitro. Transplanting it into the body for eye repair and regeneration is one of the key research directions in regenerative medicine, which also provides a novel direction and strategy for the treatment of major blinding diseases. As a carrier of biological tissue or cell growth, tissue engineering scaffold could support in vivo transplantation of eye organoids and promote their maturation. Organic combination of eye organoids and tissue engineering is a critical approach to realize in vivo integration of eye organoids and reconstruct corresponding structures and functions. In this review, the latest research status of eye organoids and in vivo transplantation were summarized, and relevant studies of tissue engineering scaffold-assisted eye organoid transplantation were highlighted, aiming to provide ideas and reference for subsequent inter-disciplinary research of eye organoids and tissue engineering.
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