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胰岛保护和功能维护的研究进展

高宏君, 邱敏华, 陈继冰. 胰岛保护和功能维护的研究进展[J]. 器官移植, 2023, 14(2): 207-212. doi: 10.3969/j.issn.1674-7445.2023.02.005
引用本文: 高宏君, 邱敏华, 陈继冰. 胰岛保护和功能维护的研究进展[J]. 器官移植, 2023, 14(2): 207-212. doi: 10.3969/j.issn.1674-7445.2023.02.005
Gao Hongjun, Qiu Minhua, Chen Jibing. Research progress on islet protection and functional maintenance[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 207-212. doi: 10.3969/j.issn.1674-7445.2023.02.005
Citation: Gao Hongjun, Qiu Minhua, Chen Jibing. Research progress on islet protection and functional maintenance[J]. ORGAN TRANSPLANTATION, 2023, 14(2): 207-212. doi: 10.3969/j.issn.1674-7445.2023.02.005

胰岛保护和功能维护的研究进展

doi: 10.3969/j.issn.1674-7445.2023.02.005
基金项目: 

广西科技基地和人才专项 桂科AD22035122

详细信息
    作者简介:
    通讯作者:

    高宏君,Email:gao4056@163.com

  • 中图分类号: R617, R587.1

Research progress on islet protection and functional maintenance

More Information
  • 摘要: 胰岛移植在糖尿病及其并发症的治疗中有很广阔的前景,但移植后功能不良、排斥反应和供体不足等是胰岛移植领域的瓶颈。优化胰腺保存方法对获取有效胰岛的数量及功能的维护有积极意义;在培养期间对胰岛进行抗排斥反应和抗凋亡处理,包括间充质干细胞(MSC)、MSC来源的外泌体、抗凋亡药物和基因修饰等可能成为临床胰岛移植胰岛保护与功能维护的重要方法;胰岛移植后抗立即经血液介导的炎症反应(IBMIR)药物的使用对于胰岛功能的保护也具有重要作用。本文围绕从胰岛制备到胰岛移植的全过程,探讨胰岛保护和功能维护相关策略,旨在为提升供体质量以弥补供体绝对数量的不足,提升胰岛移植效率提供参考。

     

  • 图  1  人羊膜间充质干细胞包裹的胰岛(免疫荧光,×200)

    注:A图为MSC用Dio绿色荧光探针标记;B图为胰岛用Dil红色荧光探针标记;C图为A图和B图的合并。

    Figure  1.  Pancreatic islets coated by human amniotic mesenchymal stem cells

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出版历程
  • 收稿日期:  2022-12-09
  • 网络出版日期:  2023-03-15
  • 刊出日期:  2023-03-15

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