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临床异种器官移植十大问题的思考

窦科峰, 张玄. 临床异种器官移植十大问题的思考[J]. 器官移植, 2022, 13(4): 411-416. doi: 10.3969/j.issn.1674-7445.2022.04.001
引用本文: 窦科峰, 张玄. 临床异种器官移植十大问题的思考[J]. 器官移植, 2022, 13(4): 411-416. doi: 10.3969/j.issn.1674-7445.2022.04.001
Dou Kefeng, Zhang Xuan. Reflection on 10 problems of clinical xenotransplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 411-416. doi: 10.3969/j.issn.1674-7445.2022.04.001
Citation: Dou Kefeng, Zhang Xuan. Reflection on 10 problems of clinical xenotransplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 411-416. doi: 10.3969/j.issn.1674-7445.2022.04.001

临床异种器官移植十大问题的思考

doi: 10.3969/j.issn.1674-7445.2022.04.001
基金项目: 

国家“973计划”项目 2015CB554100

国家重点研发计划项目 2017YFC1103703

国家自然科学基金项目 81870446

国家自然科学基金项目 82070671

国家自然科学基金项目 81900571

详细信息
    作者简介:
    通讯作者:

    窦科峰,Email:doukef@fmmu.edu.cn

  • 中图分类号: R617, Q78

Reflection on 10 problems of clinical xenotransplantation

More Information
  • 摘要: 供者短缺是影响器官移植发展的一大难题,而异种器官移植可能是解决这一难题的有效途径。随着基因编辑技术的发展以及新型免疫抑制剂的研发,异种器官移植领域取得了许多突破性的进展,但大多数研究目前仍处于临床前阶段。近期,世界首例基因编辑猪到人心脏移植的成功极大地鼓舞了科研工作者。但临床异种器官移植仍面临很多重要问题,包括克服排斥反应、控制炎症反应、调节凝血紊乱、提高移植物生理相容性、重视种间感染风险、优化免疫抑制方案、筛选供体基因编辑类型、选择适宜受者人群、完善异种移植指南、明确大众认可度等,本文就以上十大问题进行总结,以期为促进异种器官移植的临床应用提供参考。

     

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出版历程
  • 收稿日期:  2022-03-30
  • 网络出版日期:  2022-07-14
  • 刊出日期:  2022-07-15

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