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低温机械灌注在移植物功能延迟恢复高危尸体供肾 肾移植中的应用

李杨 田晓辉 丁晨光 陈国振 丁小明 项和立 田普训 郑瑾 胡筱筠 薛武军

李杨, 田晓辉, 丁晨光, 等. 低温机械灌注在移植物功能延迟恢复高危尸体供肾 肾移植中的应用[J]. 器官移植, 2020, 11(2): 259-264. doi: 10.3969/j.issn.1674-7445.2020.02.012
引用本文: 李杨, 田晓辉, 丁晨光, 等. 低温机械灌注在移植物功能延迟恢复高危尸体供肾 肾移植中的应用[J]. 器官移植, 2020, 11(2): 259-264. doi: 10.3969/j.issn.1674-7445.2020.02.012
Li Yang, Tian Xiaohui, Ding Chenguang, et al. Application of hypothermic machine perfusion in the renal transplantation from deceased donor with high-risk delayed graft function[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 259-264. doi: 10.3969/j.issn.1674-7445.2020.02.012
Citation: Li Yang, Tian Xiaohui, Ding Chenguang, et al. Application of hypothermic machine perfusion in the renal transplantation from deceased donor with high-risk delayed graft function[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 259-264. doi: 10.3969/j.issn.1674-7445.2020.02.012

低温机械灌注在移植物功能延迟恢复高危尸体供肾 肾移植中的应用

doi: 10.3969/j.issn.1674-7445.2020.02.012
基金项目: 

国家自然科学基金 81970668

陕西省科技计划项目 2019JM-116

详细信息
    作者简介:

    李杨,男,1981年生,博士,副研究员,研究方向为肾移植,Email:jullian80915@126.com

    通讯作者:

    薛武军,男,1961年生,博士,主任医师,研究方向为肾移植,Email:xwujun126@mail.xjtu.edu.cn

  • 中图分类号: R617

Application of hypothermic machine perfusion in the renal transplantation from deceased donor with high-risk delayed graft function

More Information
  • 摘要:   目的  探讨低温机械灌注(HMP)在移植物功能延迟恢复(DGF)高危尸体供者(DD)的供肾保存中的临床效果。  方法  采用前瞻性随机对照实验选取行器官捐献的52例DGF高危供者临床资料。将每例供者的2个供肾随机分为HMP组和静态冷保存(SCS)组(每组52例),HMP组供肾均采用LifePort进行低温机械灌注保存,SCS组供肾采用威斯康星大学保存液(UW液)进行冷保存。比较两组受者移植术后DGF和原发性无功能(PNF)的发生情况,观察两组受者移植肾功能恢复情况,观察肾移植术后1年内受者和移植肾的生存情况。  结果  HMP组受者DGF发生率为4%(2/52),明显低于SCS组受者的17%(9/52)(P < 0.05);HMP组无PNF病例,SCS组有1例受者发生PNF,两组比较差异无统计学意义(P > 0.05)。HMP组和SCS组受者移植肾功能恢复时间分别为(7.2±0.6)d和(7.7±1.0)d,差异无统计学意义(P > 0.05)。HMP组受者手术当日、术后1 d、术后2 d的尿量均明显多于SCS组受者(均为P < 0.05),HMP组术后各时间点的血清肌酐水平均明显低于SCS组(均为P < 0.05)。HMP组和SCS组受者术后1年的人、肾存活率分别为98.1%、92.3%和100%、96.2%,差异无统计学意义(均为P > 0.05)。  结论  HMP可显著降低DGF高危DD供肾肾移植术后DGF发生率,而且可促进早期移植肾功能的恢复。

     

  • 图  1  两组受者肾移植术后14 d内尿量和血清肌酐的变化

    注:与SCS组比较,aP < 0.05。

    Figure  1.  Changes in urine volume and serum creatinine of recipients within 14 days after renal transplantation in 2 groups

    图  2  两组受者肾移植术后1年内的生存曲线

    注:A图示术后肾存活率;B图示术后人存活率。

    Figure  2.  Survival curves of recipients within 1 year after renal transplantation in 2 groups

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出版历程
  • 收稿日期:  2019-12-29
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2020-03-15

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