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机械灌注技术引领器官捐献与移植模式的变革——器官ICU时代即将到来?

谭晓宇 陈晓兰 林金铭 梁佩乔 刘宝棋 欧阳青 霍枫

谭晓宇, 陈晓兰, 林金铭, 等. 机械灌注技术引领器官捐献与移植模式的变革——器官ICU时代即将到来?[J]. 器官移植, 2019, 10(4): 453-458. doi: 10.3969/j.issn.1674-7445.2019.04.018
引用本文: 谭晓宇, 陈晓兰, 林金铭, 等. 机械灌注技术引领器官捐献与移植模式的变革——器官ICU时代即将到来?[J]. 器官移植, 2019, 10(4): 453-458. doi: 10.3969/j.issn.1674-7445.2019.04.018

机械灌注技术引领器官捐献与移植模式的变革——器官ICU时代即将到来?

doi: 10.3969/j.issn.1674-7445.2019.04.018
基金项目: 

国家青年科学基金项目 81800556

军队实验动物专项科研项目 SYDW(2017)12

详细信息
    作者简介:

    谭晓宇,男,1980年生,博士,主治医师,研究方向为肝移植、器官捐献与维护,Email:dr.tanxiaoyu@hotmail.com

    通讯作者:

    霍枫,男,1961年生,硕士,主任医师,研究方向为肝移植、器官捐献与维护,Email:gzhuofeng@163.com

  • 中图分类号: R617

  • 摘要: 机械灌注(MP)技术是器官移植领域的全球研究热点之一,近年的探索成果显示出其在器官保存、器官活力评估、修复受损器官中的优异性,将引领器官捐献与移植模式的变革。本文就近期MP技术在提升器官保存效果、评估器官活力、修复器官以及进行干预性治疗等方面的研究进展进行综述,并讨论未来临床应用的潜在模式。

     

  • 图  1  离体肝脏灌注设备(第5代)

    Figure  1.  Isolated hepatic perfusion equipment (the fifth generation)

    图  2  动物离体肝脏的HMP和NMP实验

    Figure  2.  HMP and NMP experiment of isolated liver of animal

    图  3  废弃人供肝HMP和NMP实验

    Figure  3.  HMP and NMP experiment of abandoned human donor liver

    图  4  器官ICU的新型管理模式流程

    Figure  4.  New management model flow of organ ICU

    表  1  NMP支持下成功移植的供肝灌注指标[27]

    Table  1.   Perfusion indicators of successful liver transplantation supported by NMP

    指标 具体内容
    血流动力学参数 肝动脉流量(280±120)mL/min
    门静脉流量(1 110±200)mL/min
    代谢参数 pH值7.31±0.17
    灌注15 min时乳酸(9.99±3.13)mmol/L
    灌注4 h后乳酸(0.93±0.63)mmol/L
    胆汁生成量 (9.17±11.16)mL/h
    下载: 导出CSV

    表  2  器官ICU与ICU的特点

    Table  2.   Features of organ ICU and ICU

    分类 器官ICU特点 ICU特点
    功能 评估器官质量 危重症患者的评估
    器官功能维持 危重症患者器官功能维护
    修复器官功能 危重症患者救治
    收治对象 边缘器官和高风险器官 危重症患者
    管理形式 MP设备 ICU
    下载: 导出CSV
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出版历程
  • 收稿日期:  2019-04-07
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2019-07-15

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