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MicroRNA在同种及异种移植免疫排斥监测中的研究进展及应用前景

林善 陆赢 蔡志明 戴一凡 牟丽莎

林善, 陆赢, 蔡志明, 等. MicroRNA在同种及异种移植免疫排斥监测中的研究进展及应用前景[J]. 器官移植, 2018, 9(3): 169-173. doi: 10.3969/j.issn.1674-7445.2018.03.001
引用本文: 林善, 陆赢, 蔡志明, 等. MicroRNA在同种及异种移植免疫排斥监测中的研究进展及应用前景[J]. 器官移植, 2018, 9(3): 169-173. doi: 10.3969/j.issn.1674-7445.2018.03.001

MicroRNA在同种及异种移植免疫排斥监测中的研究进展及应用前景

doi: 10.3969/j.issn.1674-7445.2018.03.001
基金项目: 

国家重点研发计划 2017YFC1103704

深圳市医疗卫生三名工程 SZSM201412020

深圳市高水平医学学科建设专项基金 2016031638

深圳市科技计划 JCJY20160229204849975

深圳市科技计划 GJHZ20170314171357556

深圳市卫生计生系统科研项目 SZXJ2017021

详细信息
    作者简介:

    林善,男,1989年生,博士,助理研究员,研究方向为异种胰岛移植,Email:biotechlin@foxmail.com

    蔡志明,主任医师、教授、博士研究生导师。现任深圳大学泌尿生殖研究所所长,国家泌尿生殖肿瘤中心副主任,国家地方联合肿瘤工程实验室主任,广东省泌尿生殖肿瘤重点实验室主任,国家“973”计划首席科学家,教育部“长江学者计划”、中共中央组织部“千人计划”等高层次人才评审专家,享受国务院特殊津贴。作为负责人先后承担国家“973”计划、“863”计划、国家自然科学基金、博士点基金等研究项目15项;发表SCI论文170多篇,总影响因子超过1 100分,他引频次超过6 500次,在《Nature》、《Nature Genetics》、《Nature Biotechnology》和《Cell》等国际著名刊物发表论文7篇;出版著作4部,获得国家、省、市奖项9项;培养硕士、博士(后)100多名。获全国先进工作者、全国优秀院长、深圳市科技奖市长奖等荣誉称号

    通讯作者:

    蔡志明,男,1956年生,博士,主任医师,研究方向为异种胰岛移植,Email:caizhiming2000@163.com

    牟丽莎,女,1983年生,博士,副研究员,研究方向为异种胰岛移植,Email:molly__molly@163.com

  • 中图分类号: R617, R392.4

  • 摘要: 细胞、组织及器官移植是治疗器官功能衰竭、癌症等重大疾病直接有效的治疗策略。免疫排斥是同种及异种移植研究领域中难以彻底攻克的难题,因此对移植受体免疫排斥反应的实时监测尤为重要,针对同种及异种移植开发具有特异度高、早期灵敏度高、非侵入、快速等优点的生物标志物及其监测方法非常迫切。微小核糖核酸(miRNA)在免疫细胞的生成、发育以及免疫性功能中发挥重要的作用。本文对常规免疫排斥监测方法的局限性、miRNA的生物学特性以及miRNA在同种和异种移植免疫排斥中的应用进行总结,以探讨miRNA在同种和异种移植免疫排斥监测中的应用前景。

     

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出版历程
  • 收稿日期:  2018-03-22
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2018-05-15

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