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流体剪切力在移植肾机械灌注中的机制及研究进展

王诚 李选鹏 郭霜 张驌 付生军 杨立

王诚, 李选鹏, 郭霜, 等. 流体剪切力在移植肾机械灌注中的机制及研究进展[J]. 器官移植, 2018, 9(2): 159-161, 168. doi: 10.3969/j.issn.1674-7445.2018.02.013
引用本文: 王诚, 李选鹏, 郭霜, 等. 流体剪切力在移植肾机械灌注中的机制及研究进展[J]. 器官移植, 2018, 9(2): 159-161, 168. doi: 10.3969/j.issn.1674-7445.2018.02.013

流体剪切力在移植肾机械灌注中的机制及研究进展

doi: 10.3969/j.issn.1674-7445.2018.02.013
基金项目: 

甘肃省自然科学基金 17JR5RA237

详细信息
    作者简介:

    王诚,男,1990年生,硕士研究生,研究方向为肾缺血-再灌注损伤机制,Email: 692166615@qq.com

    通讯作者:

    杨立,男,1970年生,博士后,主任医师,教授,研究方向为器官移植基础研究,Email: professoryangli@163.com

  • 中图分类号: R617

  • 摘要: 近年来,机械灌注临床应用日益成熟,相关设备开发越加完善,其临床获益效果也逐步得到认可。然而,机械灌注对于肾脏的保护机制仍然不明确,可能与机械灌注可以不断提供营养、带走代谢废物以及模拟生理条件下血管内皮经受流体剪切力(FSS)的内环境密切相关。本文就FSS缺失诱发氧化应激反应、FSS突现加重氧化应激损伤以及FSS在机械灌注保存移植肾中的作用进行综述。

     

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出版历程
  • 收稿日期:  2017-11-05
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2018-03-15

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