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摘要: 半个多世纪以来,移植免疫研究一直是免疫学家和移植外科业界关注的热点。在器官移植技术得到普遍开展和应用的今天,移植免疫排斥反应问题仍然没有得到根本解决,成为阻碍器官移植发展和导致移植物功能丧失的主要原因。显微外科技术的发展和动物模型的建立,尤其是小鼠动物模型的建立,使移植免疫研究如虎添翼地得到快速发展。本文对小鼠模型的优势、不同器官移植模型的建立方法、功能与应用等进行归纳总结,以期对未来移植免疫和移植外科的实验研究以及转化医学研究有所帮助。
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