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摘要: 抗体介导的排斥反应(AMR)是导致移植肾失功的首要原因, 而供者特异性抗体(DSA)是诊断移植肾体液性排斥反应的必要因素之一。因此, DSA检测方法的选择、技术的灵敏度和特异度对AMR的诊断和治疗有着重要的指导意义。随着器官移植外科手术水平的提高和新型免疫抑制剂的出现, 移植免疫学检测技术也在不断发展。本文对DSA的免疫学检测方法, 特别是应用Luminex-单抗原微珠法检测DSA的意义、技术优势及不足进行综述。
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关键词:
- 肾移植 /
- 供者特异性抗体 /
- 抗体介导的排斥反应 /
- Luminex-单抗原微珠法
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