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肾移植术后BK病毒相关性肾病合并环孢素中毒1例报告

解俊杰 范宇 柏宏伟 李钢 刘路鹏 钱叶勇

解俊杰, 范宇, 柏宏伟, 等. 肾移植术后BK病毒相关性肾病合并环孢素中毒1例报告[J]. 器官移植, 2014, 5(6): 377-379. doi: 10.3969/j.issn.1674-7445.2014.06.011
引用本文: 解俊杰, 范宇, 柏宏伟, 等. 肾移植术后BK病毒相关性肾病合并环孢素中毒1例报告[J]. 器官移植, 2014, 5(6): 377-379. doi: 10.3969/j.issn.1674-7445.2014.06.011

肾移植术后BK病毒相关性肾病合并环孢素中毒1例报告

doi: 10.3969/j.issn.1674-7445.2014.06.011
基金项目: 

首都临床特色应用研究 Z131107002213139

详细信息
    通讯作者:

    钱叶勇, Email:qianyy@medmail.com.cn

  • 中图分类号: R617

  • 图  1  肾移植术后BK病毒相关性肾病合并环孢素中毒患者的移植肾组织病理表现

    注:A图为发病时表现(免疫组织化学染色,×400) ,可见肾小球系膜基质节段性轻微增生,细小动脉分支基本正常,肾小管上皮细胞水肿、变性及细胞核消失,极少数肾小管坏死并脱落于管腔;C4d(-);BKV T抗原染色(+),即提示BKV(+)。B图为治疗后4个月表现(免疫组织化学染色,×800) ,BKV(-)

    Figure  1.  Pathological features of renal allograft tissue of patients with BK virus associated nephropathy combined with cyclosporine toxicity after renal transplantation

  • [1] Boothpur R, Brennan DC. Human polyoma viruses and disease with emphasis on clinical BK and JC[J]. J Clin Virol, 2010, 47(4):306-312. doi: 10.1016/j.jcv.2009.12.006
    [2] 范宇, 石炳毅, 钱叶勇, 等. 尿液与血液病毒载量在肾移植受者BK病毒性肾病诊断中的应用[J]. 中华器官移植杂志, 2013, 34(10): 595-598.

    Fang Y, Shi BY, Qian YY, et al. The cut-off value of BK virus DNA load in urine or plasma for diagnosis of BKVN in renal transplantation recipients[J]. Chin J Organ Transplant, 2013, 34(10): 595-598.
    [3] Pham PT, Reddy UG. Transplantation: immunosuppression and risk of polyomavirus BK replication[J]. Nat Rev Nephrol, 2013, 9(3):135-136. doi: 10.1038/nrneph.2013.17
    [4] Mengel M, Marwedel M, Radermacher J, et al. Incidence of polyomavirus-nephropathy in renal allografts: influence of modern immunosuppressive drugs[J]. Nephrol Dial Transplant, 2003, 18(6):1190-1196. doi: 10.1093/ndt/gfg072
    [5] Hirsch HH, Knowles W, Dickenmann M. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients[J].N Engl J Med, 2002, 347(7):488-496. doi: 10.1056/NEJMoa020439
    [6] Schold JD, Rehman S, Kayle LK, et al. Treatment for BK virus: incidence, risk factors and outcomes for kidney transplant recipients in the United States[J]. Transpl Int, 2009, 22(6):626-634. doi: 10.1111/tri.2009.22.issue-6
    [7] Kidney Disease: Improving Global Outcomes (KDIGO)Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients[J]. Am J Transplant, 2009, 9(Suppl 3):S1-S155.
    [8] Huang G, Chen LZ, Qiu J, et al. Prospective study of polyomavirus BK replication and nephropathy in renal transplant recipients in China: a single-center analysis of incidence, reduction in immunosuppression and clinical course[J]. Clin Transplant, 2010, 24(5):599-609. doi: 10.1111/ctr.2010.24.issue-5
    [9] Geddes CC, Gunson R, Mazonakis E, et al. BK viremia surveillance after kidney transplant: single-center experience during a change from cyclosporine-tolower-dose tacrolimus-based primary immunosuppression regimen[J]. Transpl Infect Dis, 2011, 13(2): 109-116. doi: 10.1111/tid.2011.13.issue-2
    [10] Sawinski D, Goral S.BK virus infection: an update on diagnosis and treatment[J]. Nephrol Dial Transplant, 2014, DOI: 10.1093/ndt/gfu023[Epub ahead of print].
    [11] Hammarin AL, Öqvist B, Wahlgren J, et al. Systematic screening of BK virus by real-time PCR prevents BK virus associated nephropathy in renal transplantrecipients[J]. J Med Virol, 2011, 83(11):1959-1965. doi: 10.1002/jmv.v83.11
    [12] 解俊杰, 钱叶勇, 石炳毅, 等. 抢救性治疗对肾移植后BK病毒感染及其相关性肾病的临床效果[J]. 中华器官移植杂志, 2013, 34(2): 105-109.

    Xie JJ, Qian YY, Shi BY, et al. Clinical observation of BK viremia and BK virus-associated nephropathy with rescuing therapy in renal transplant recipients[J]. Chin J Organ Transplant, 2013, 34(2): 105-109.
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出版历程
  • 收稿日期:  2014-08-26
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2014-11-15

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