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胰岛移植即刻经血液介导的炎症反应应对策略

杨玉伟, 张婷, 李万里, 等. 胰岛移植即刻经血液介导的炎症反应应对策略[J]. 器官移植, 2023, 14(3): 352-357. doi: 10.3969/j.issn.1674-7445.2023.03.005
引用本文: 杨玉伟, 张婷, 李万里, 等. 胰岛移植即刻经血液介导的炎症反应应对策略[J]. 器官移植, 2023, 14(3): 352-357. doi: 10.3969/j.issn.1674-7445.2023.03.005
Yang Yuwei, Zhang Ting, Li Wanli, et al. Therapeutic strategy for instant blood-mediated inflammatory reaction after islet transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 352-357. doi: 10.3969/j.issn.1674-7445.2023.03.005
Citation: Yang Yuwei, Zhang Ting, Li Wanli, et al. Therapeutic strategy for instant blood-mediated inflammatory reaction after islet transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 352-357. doi: 10.3969/j.issn.1674-7445.2023.03.005

胰岛移植即刻经血液介导的炎症反应应对策略

doi: 10.3969/j.issn.1674-7445.2023.03.005
基金项目: 

广西科技基地和人才专项 桂科AD22035122

广西研究生教育创新计划项目 YCSW2022355

广西研究生教育创新计划项目 YCXJ2021091

详细信息
    作者简介:
    通讯作者:

    高宏君(ORCID:0000-0003-1451-0725),博士,主任医师,研究方向器官移植与胰岛移植,Email:gao4056@163.com

  • 中图分类号: R617, R587

Therapeutic strategy for instant blood-mediated inflammatory reaction after islet transplantation

More Information
  • 摘要: 胰岛移植作为治疗1型糖尿病和终末期2型糖尿病的有效手段,可以使患者获得较好的血糖控制能力。即刻经血液介导的炎症反应(IBMIR)是胰岛移植早期出现的非特异性炎症反应,发生后可迅速出现凝血级联和补体系统激活、炎症细胞聚集等,造成大量移植胰岛丢失,严重影响胰岛移植的疗效。如何减轻IBMIR对胰岛造成损伤是目前胰岛移植的研究热点,临床推荐的治疗胰岛移植IBMIR的药物有肝素和肿瘤坏死因子-α抑制剂依那西普。新近研究表明多种方法和药物可以减轻IBMIR对胰岛的损伤,本文就这些临床研究成果和临床前研究成果进行综述,以期为胰岛移植IBMIR的应对提供参考。

     

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出版历程
  • 收稿日期:  2022-11-16
  • 刊出日期:  2023-05-15

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