Abstract: Communication with families of donors is the critical procedure of organ and tissue donation, which is the key to determine the success of donation. Expert Consensus on Communication with Families of Organ and Tissue Donors was formulated by multidisciplinary experts to help the families of potential organ and tissue donors to understand the right of independent decision of organ donation given by law, improve the communication efficiency with families, fully showcase the humanistic care, enable relevant practitioners to maintain professional working status and healthy psychological state in the long term, share and summarize the optimal clinical experiences in different places, and discuss and resolve the difficulties during the communication with families. This expert consensus focuses on the key issues during the communication with families of organ and tissue donors and formulated by multidisciplinary experts after literature review. The expert panel has reached consensus by Delphi method for voting. Eighteen key elements and recommendations for communication with families of potential organ and tissue donors have been proposed, aiming to provide guidance for communication with families of organ and tissue donation. This consensus has been registered both in Chinese and English on International Practice Guidelines Registry Platform.