全胰腺切除联合自体胰岛移植治疗慢性胰腺炎1例报道并文献复习

Total pancreatectomy-islet autotransplantation in treatment of chronic pancreatitis: report of one case and literature review

    摘要
  • 摘要:
      目的  探讨全胰腺切除联合自体胰岛移植（TP-IAT）治疗慢性胰腺炎的临床疗效。
      方法  佛山市第一人民医院对1例合并多发假性囊肿、胰腺结石的难治性慢性胰腺炎患者行TP-IAT治疗，并对其随访3个月的临床资料进行总结与分析。
      结果  患者TP-IAT术后恢复顺利，无发生出血、严重低血糖等并发症，腹痛完全缓解，未服用镇痛药物。随访期间患者使用外源性胰岛素，空腹血糖控制理想，胰岛细胞功能部分恢复。
      结论  TP-IAT既能缓解慢性胰腺炎的临床症状，也能预防术后糖尿病的发生，是治疗难治性慢性胰腺炎的有效手段。

     

    Abstract:
      Objective  To evaluate the clinical efficacy of total pancreatectomy-islet autotransplantation (TP-IAT) in the treatment of chronic pancreatitis.
      Methods  One patient diagnosed with refractory chronic pancreatitis complicated with multiple pseudocysts and pancreatic stones underwent TP-IAT in the First People's Hospital of Foshan. Clinical data were collected and analyzed during postoperative 3 months follow-up.
      Results  The patient was well recovered after TP-IAT without complications, such as bleeding and severe hypoglycemia. Abdominal pain was completely relieved without taking analgesic drugs. During postoperative follow-up, the patient was treated with exogenous insulin, the fasting blood glucose was properly controlled and the function of islet cells was partially restored.
      Conclusions  TP-IAT can not only relieve the clinical symptoms of chronic pancreatitis, but also prevent postoperative diabetes mellitus, which is an efficacious treatment of refractory chronic pancreatitis.

     

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