供肺保存技术的机制演进与临床分层决策

Mechanistic evolution and clinical stratification decision-making in donor lung preservation technology

  • 摘要: 供肺保存质量和保存时限直接影响肺移植供者利用率及受者结局。传统静态冷保存仍是当前临床最常用的供肺保存方式,但其安全保存时间有限,且随冷缺血时间延长,缺血-再灌注损伤风险增加。近年来,10 ℃受控低温保存、离体肺灌注及过冷保存等新策略逐渐应用于延长供肺保存时间、优化转运流程及提高边缘供肺利用等方面。本文就上述保存策略的生物学机制、临床证据、卫生经济学特点及应用场景进行综述,并结合供者质量和物流条件探讨供肺保存的分层决策思路,以期为临床选择适宜的保存策略提供参考。

     

    Abstract: The quality and preservation time of donor lungs directly affect the utilization rate of lung transplant donors and the outcomes of recipients. The traditional static cold storage is still the most commonly used method for preserving donor lungs in clinical practice, but its safe preservation time is limited, and as the cold ischemia time prolongs, the risk of ischemia-reperfusion injury increases. In recent years, new strategies such as 10 ℃ controlled hypothermic storage, ex vivo lung perfusion and supercooling preservation have gradually been applied to extend the preservation time of donor lungs, optimize the transportation process, and improve the utilization of marginal donor lungs. This article reviews the biological mechanisms, clinical evidence, health economic characteristics and application scenarios of the above preservation strategies, and discusses the stratified decision-making approach for donor lung preservation based on donor quality and logistics conditions, with the aim of providing a reference for clinical selection of appropriate preservation strategies.

     

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