Optimization of immunosuppressive regimen for kidney transplant recipients

Dong Zhen; Wang Hongyang

doi:10.3969/j.issn.1674-7445.2024087

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Dong Zhen, Wang Hongyang. Optimization of immunosuppressive regimen for kidney transplant recipients[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024087

Citation:

Dong Zhen, Wang Hongyang. Optimization of immunosuppressive regimen for kidney transplant recipients[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024087

Citation:

Dong Zhen, Wang Hongyang. Optimization of immunosuppressive regimen for kidney transplant recipients[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024087

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Optimization of immunosuppressive regimen for kidney transplant recipients

doi: 10.3969/j.issn.1674-7445.2024087

Dong Zhen^,,
Wang Hongyang

Department of Kidney Transplantation, Qingdao University Affiliated Hospital, Qin Dao 266000, China

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Corresponding author: Dong Zhen, Email: dong266000@163.com
Received Date: 2024-03-05
Available Online: 2024-04-29

Abstract

Abstract

With the maturity and development of surgical techniques, as well as the improvement of perioperative management level, the success rate of kidney transplantation has been significantly improved. However, due to evident differences in heredity and antigenicity between donors and recipients, rejection will occur after kidney transplantation, which will affect the survival of renal grafts. Immunosuppression is an important treatment for rejection, which is of significance to reduce the risk of rejection and enhance graft survival rate. Nevertheless, immunosuppressants may cause multiple complications while lowering the incidence of rejection, such as infection, cardiovascular diseases and tumors, etc., which seriously affect the quality of life of patients and may even lead to their death. Reasonable selection of immunosuppressants and continuous optimization of immunosuppressive regimen for recipients play a critical role in improving the survival of recipients and renal grafts. In this article, the development history of organ transplantation, immune induction therapy and immune maintenance therapy was reviewed, and the progress in the optimization of immunosuppressive regimens for kidney transplant recipients was discussed, aiming to provide reference for improving clinical prognosis of kidney transplant recipients.
- Kidney transplantation,
- Immunosuppressant,
- Immune induction,
- Immune maintenance,
- Infection,
- Glucocorticoid,
- Calcineurin inhibitor,
- Antiproliferative drug

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References(38)

References

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Optimization of immunosuppressive regimen for kidney transplant recipients

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