Turn off MathJax
Article Contents
Zuo Yujie, Liu Menggen, Wan Jiaxin, et al. Latest research progress in airway stenosis after lung transplantation[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024075
Citation: Zuo Yujie, Liu Menggen, Wan Jiaxin, et al. Latest research progress in airway stenosis after lung transplantation[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024075

Latest research progress in airway stenosis after lung transplantation

doi: 10.3969/j.issn.1674-7445.2024075
More Information
  • With the optimization of surgical technologies and postoperative management regimens, the number of lung transplantation has been significantly increased, which has become an important treatment for patients with end-stage lung disease. However, due to the impact of comprehensive factors, such as bronchial ischemia and immunosuppression, the incidence of airway stenosis after lung transplantation is relatively high, which severely affects postoperative survival and quality of life of lung transplant recipients. In recent years, with the improvement of perioperative management, organ preservation and surgical technologies, the incidence of airway stenosis after lung transplantation has been declined, but it remains at a high level. Early diagnosis and timely intervention play a significant role in enhancing clinical prognosis of patients with airway stenosis. In this article, the general conditions, diagnosis, treatment and prevention of airway stenosis after lung transplantation were reviewed, aiming to provide reference for comprehensive management of airway stenosis after lung transplantation and improving clinical prognosis of lung transplant recipients.

     

  • loading
  • [1]
    CHAMBERS DC, PERCH M, ZUCKERMANN A, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult lung transplantation report - 2021; focus on recipient characteristics[J]. J Heart Lung Transplant, 2021, 40(10): 1060-1072. DOI: 10.1016/j.healun.2021.07.021.
    [2]
    WANG Z, ZHAO B, DENG M, et al. Utility and safety of airway stenting in airway stenosis after lung transplant: a systematic review[J]. Front Med (Lausanne), 2023, 10: 1061447. DOI: 10.3389/fmed.2023.1061447.
    [3]
    NELSON J, KINCAIDE E, SCHULTE J, et al. Immunosuppression in lung transplantation[J]. Handb Exp Pharmacol, 2022, 272: 139-164. DOI: 10.1007/164_2021_548.
    [4]
    CRESPO MM, MCCARTHY DP, HOPKINS PM, et al. ISHLT consensus statement on adult and pediatric airway complications after lung transplantation: definitions, grading system, and therapeutics[J]. J Heart Lung Transplant, 2018, 37(5): 548-563. DOI: 10.1016/j.healun.2018.01.1309.
    [5]
    DELBOVE A, SENAGE T, GAZENGEL P, et al. Incidence and risk factors of anastomotic complications after lung transplantation[J]. Ther Adv Respir Dis, 2022, 16: 17534666221110354. DOI: 10.1177/17534666221110354.
    [6]
    FELTON TW, ROBERTS SA, ISALSKA B, et al. Isolation of Aspergillus species from the airway of lung transplant recipients is associated with excess mortality[J]. J Infect, 2012, 65(4): 350-356. DOI: 10.1016/j.jinf.2012.07.008.
    [7]
    PUCHALSKI J, LEE HJ, STERMAN DH. Airway complications following lung transplantation[J]. Clin Chest Med, 2011, 32(2): 357-366. DOI: 10.1016/j.ccm.2011.03.001.
    [8]
    SUH JW. Surgical complications affecting the early and late survival rates after lung transplantation[J]. J Chest Surg, 2022, 55(4): 332-337. DOI: 10.5090/jcs.22.059.
    [9]
    CHAMOGEORGAKIS T, MOQUIN K, SIMOFF M, et al. Repair of bronchial anastomosis following lung transplantation[J]. Thorac Cardiovasc Surg, 2022, 70(6): 527-530. DOI: 10.1055/s-0041-1723002.
    [10]
    YU DH, LIN Q, FAN C, et al. Resistin pathway as novel mechanism of post-lung transplantation bronchial stenosis[J]. J Bronchology Interv Pulmonol, 2024, 31(1): 30-38. DOI: 10.1097/LBR.0000000000000925.
    [11]
    LUECKE K, TRUJILLO C, FORD J, et al. Anastomotic airway complications after lung transplant: clinical, bronchoscopic and CT correlation[J]. J Thorac Imaging, 2016, 31(5): W62-W71. DOI: 10.1097/RTI.000000 0000000227.
    [12]
    FURUKAWA M, CHAN EG, MORRELL MR, et al. Risk factors of bronchial dehiscence after primary lung transplantation[J]. J Card Surg, 2022, 37(4): 950-957. DOI: 10.1111/jocs.16291.
    [13]
    SCHWEIGER T, SCHWARZ S, TRAXLER D, et al. Bronchoscopic indocyanine green fluorescence imaging of the anastomotic perfusion after tracheal surgery[J]. Ann Thorac Surg, 2016, 101(5): 1943-1949. DOI: 10.1016/j.athoracsur.2015.11.058.
    [14]
    VAN PEL R, GAN CT, VAN DER BIJ W, et al. Three decades single center experience of airway complications after lung transplantation[J]. Transpl Int, 2023, 36: 11519. DOI: 10.3389/ti.2023.11519.
    [15]
    HASEGAWA T, IACONO AT, ORONS PD, et al. Segmental nonanastomotic bronchial stenosis after lung transplantation[J]. Ann Thorac Surg, 2000, 69(4): 1020-1024. DOI: 10.1016/s0003-4975(99)01556-8.
    [16]
    SOUILAMAS R, WERMERT D, GUILLEMAIN R, et al. Uncommon combined treatment of nonanastomotic bronchial stenosis after lung transplantation[J]. J Bronchol, 2008, 15(1): 54-55. DOI: 10.1097/LBR.0b013e318162c415.
    [17]
    史灵芝, 黄桁, 刘明昭, 等. 肺移植术后需要临床干预的气道狭窄患者生存结局的影响因素[J]. 器官移植, 2024, 15(2): 236-243. DOI: 10.3969/j.issn.1674-7445.2023236.

    SHI LZ, HUANG H, LIU MZ, et al. Influencing factors of survival of patients with airway stenosis requiring clinical interventions after lung transplantation[J]. Organ Transplant, 2024, 15(2): 236-243. DOI: 10.3969/j.issn.1674-7445.2023236.
    [18]
    JINDAL A, AVASARAL S, GREWAL H, et al. Airway complications following lung transplantation[J]. Indian J Thorac Cardiovasc Surg, 2022, 38(Suppl 2): 326-334. DOI: 10.1007/s12055-022-01376-5.
    [19]
    LATOS M, NĘCKI M, URLIK M, et al. Effect of bronchoscopic interventions on long-term lung function among lung transplant recipients due to cystic fibrosis: a single-center study[J]. Transplant Proc, 2022, 54(4): 1086-1091. DOI: 10.1016/j.transproceed.2022.02.059.
    [20]
    NEAGOS GR, MARTINEZ FJ, DEEB GM, et al Diagnosis of unilateral mainstem bronchial obstruction following single-lung transplantation with routine spirometry[J]. Chest, 1993, 103(4): 1255-1258. DOI: 10.1378/chest.103.4.1255.
    [21]
    吴秀秀, 王婷, 王娟, 等. 急诊支气管镜介入治疗在恶性气道狭窄患者中的抢救价值[J]. 中国呼吸与危重监护杂志, 2022, 21(10): 715-719. DOI: 10.7507/1671-6205.202209042.

    WU XX, WANG T, WANG J, et al. Rescue value of emergency bronchoscopic interventional therapy in patients with malignant airway stenosis[J]. Chin J Respir Crit Care Med, 2022, 21(10): 715-719. DOI: 10.7507/1671-6205.202209042.
    [22]
    MURTHY SC, GILDEA TR, MACHUZAK MS. Anastomotic airway complications after lung transplantation[J]. Curr Opin Organ Transplant, 2010, 15(5): 582-587. DOI: 10.1097/MOT.0b013e32833e3e6e.
    [23]
    MORA-CUESTA VM, TELLO-MENA S, IZQUIERDO-CUERVO S, et al. Bronchial stenosis after lung transplantation from cDCD donors using simultaneous abdominal normothermic regional perfusion: a single-center experience[J]. Transplantation, 2023, 107(11): 2415-2423. DOI: 10.1097/TP.0000000000004698.
    [24]
    TREMBLAY A, COULTER TD, MEHTA AC. Modification of a mucosal-sparing technique using electrocautery and balloon dilatation in the endoscopic management of web-like benign airway stenosis[J]. J Bronchol, 2003, 10(4): 268-271. DOI: 10.1097/00128594-200310000-00006.
    [25]
    IZHAKIAN S, WASSER W, UNTERMAN A, et al. Long-term success of metal endobronchial stents in lung transplant recipients[J]. Thorac Cardiovasc Surg, 2022, 70(6): 520-526. DOI: 10.1055/s-0040-1721461.
    [26]
    COSANO-POVEDANO J, MUÑOZ-CABRERA L, JURADO-GÁMEZ B, et al. Topical mitomycin C for recurrent bronchial stenosis after lung transplantation: a report of 2 cases[J]. J Bronchol, 2008, 15(4): 281-283. DOI: 10.1097/LBR.0b013e3181879e3a.
    [27]
    MONDONI M, RINALDO RF, SOLIDORO P, et al. Interventional pulmonology techniques in lung transplantation[J]. Respir Med, 2023, 211: 107212. DOI: 10.1016/j.rmed.2023.107212.
    [28]
    FITZSULLIVAN E, GRIES CJ, PHELAN P, et al. Reduction in airway complications after lung transplantation with novel anastomotic technique[J]. Ann Thorac Surg, 2011, 92(1): 309-315. DOI: 10.1016/j.athoracsur.2011.01.077.
    [29]
    VAN BERKEL V, GUTHRIE TJ, PURI V, et al. Impact of anastomotic techniques on airway complications after lung transplant[J]. Ann Thorac Surg, 2011, 92(1): 316-321. DOI: 10.1016/j.athoracsur.2011.03.031.
    [30]
    杨航, 卫栋, 张稷, 等. 肺移植术后中心气道狭窄危险因素分析[J]. 器官移植, 2022, 13(2): 240-245. DOI: 10.3969/j.issn.1674-7445.2022.02.013.

    YANG H, WEI D, ZHANG J, et al. Risk factors analysis of central airway stenosis after lung transplantation[J]. Organ Transplant, 2022, 13(2): 240-245. DOI: 10.3969/j.issn.1674-7445.2022.02.013.
    [31]
    SOETANTO V, GREWAL US, MEHTA AC, et al. Early postoperative complications in lung transplant recipients[J]. Indian J Thorac Cardiovasc Surg, 2022, 38(Suppl 2): 260-270. DOI: 10.1007/s12055-021-01178-1.
    [32]
    VARELA A, HOYOS L, ROMERO A, et al. Management of bronchial complications after lung transplantation and sequelae[J]. Thorac Surg Clin, 2018, 28(3): 365-375. DOI: 10.1016/j.thorsurg.2018.04.006.
    [33]
    MUÑOZ-FOS A, MORENO P, GONZÁLEZ FJ, et al. Airway complications after lung transplantation-a contemporary series of 400 bronchial anastomoses from a single center[J]. J Clin Med, 2023, 12(9): 3061. DOI: 10.3390/jcm12093061.
    [34]
    VAN DE WAUWER C, VAN RAEMDONCK D, VERLEDEN GM, et al. Risk factors for airway complications within the first year after lung transplantation[J]. Eur J Cardiothorac Surg, 2007, 31(4): 703-710. DOI: 10.1016/j.ejcts.2007.01.025.
    [35]
    SANTACRUZ JF, MEHTA AC. Airway complications and management after lung transplantation: ischemia, dehiscence, and stenosis[J]. Proc Am Thorac Soc, 2009, 6(1): 79-93. DOI: 10.1513/pats.200808-094GO.
    [36]
    KIM HH, JO KW, SHIM TS, et al. Incidence, risk factors, and clinical characteristics of airway complications after lung transplantation[J]. Sci Rep, 2023, 13(1): 667. DOI: 10.1038/s41598-023-27864-1.
    [37]
    SUBASI M, DUGER M. Preoperative risk factors of airway complications in adult lung transplant recipients: a systematic review and meta-analysis[J]. Turk Gogus Kalp Damar Cerrahisi Derg, 2023, 31(4): 517-529. DOI: 10.5606/tgkdc.dergisi.2023.25399.
    [38]
    VENUTA F, RENDINA EA, BUFI M, et al. Preimplantation retrograde pneumoplegia in clinical lung transplantation[J]. J Thorac Cardiovasc Surg, 1999, 118(1): 107-714. DOI: 10.1016/S0022-5223(99)70149-2.
    [39]
    VARELA A, MONTERO CG, CÓRDOBA M, et al. Improved distribution of pulmonary flush solution to the tracheobronchial wall in pulmonary transplantation[J]. Eur Surg Res, 1997, 29(1): 1-4. DOI: 10.1159/000129500.
    [40]
    DENLINGER CE, MEYERS BF. Update on lung transplantation for emphysema[J]. Thorac Surg Clin, 2009, 19(2): 275-283. DOI: 10.1016/j.thorsurg.2009.03.001.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (12) PDF downloads(0) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return