Transmission of porcine endogenous retrovirus in xenotransplantation

Yu Yifan; Song Jiahua; Song Xiangqin; Li Tao; Jiang Jian; Bai Yunhao; Wang Yi

doi:10.3969/j.issn.1674-7445.2023293

Volume 14 Issue 5

Sep. 2023

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Yu Yifan, Song Jiahua, Song Xiangqin, et al. Transmission of porcine endogenous retrovirus in xenotransplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 754-759. doi: 10.3969/j.issn.1674-7445.2023293

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Transmission of porcine endogenous retrovirus in xenotransplantation

doi: 10.3969/j.issn.1674-7445.2023293

1.
Transplantation Institute, the Second Affiliated Hospital of Hainan Medical University, Hainan 570216, China

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Corresponding author: Wang Yi, Email:wayne0108@126.com
Received Date: 2023-04-30
Accepted Date: 2023-07-10

Available Online: 2023-07-20

Publish Date: 2023-09-15

Abstract

Abstract

Organ transplantation is the most effective treatment for various types of end-stage diseases. To resolve the problem of donor shortage in organ transplantation, the possibility of xenotransplantation has been gradually explored by surgeons. Pig is one of the common donor sources for xenotransplantation. As a bridge between two species, the viruses carried by pig organs may be transmitted between species and cause the risk of zoonosis. Porcine endogenous retrovirus (PERV) is integrated into the genome, which is a category of retrovirus featuring cross-species transmission. In this article, the influencing factors of transmission characteristics of PERV, the transmission risk of PERV and its recombinant virus, and the detection and transmission risk assessment of PERV in xenotransplantation test were reviewed, aiming to provide reference for alleviating severe shortage of donor organs and driving the advancement of xenotransplantation technologies.
- Xenotransplantation,
- Porcine endogenous retrovirus,
- Organ shortage,
- Transgene,
- Transmission characteristics,
- Zoonosis,
- Immunodeficiency,
- Infection

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References(43)

References

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Transmission of porcine endogenous retrovirus in xenotransplantation

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