Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation

Gu Meirong; Liu Minqiang; Dai Taoyin; Gu Sijia; Li Xiaoshan; Xu Bo; Hu Chunxiao; Chen Jingyu

doi:10.3969/j.issn.1674-7445.2023200

Volume 15 Issue 2

Mar. 2024

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Gu Meirong, Liu Minqiang, Dai Taoyin, et al. Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation[J]. ORGAN TRANSPLANTATION, 2024, 15(2): 251-256. doi: 10.3969/j.issn.1674-7445.2023200

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Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation

doi: 10.3969/j.issn.1674-7445.2023200

1.
Wuxi Medical Center, Nanjing Medical University, Wuxi People's Hospital, Department of Anesthesiology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China

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Corresponding author: Hu Chunxiao, Email: huchunxiao91211@163.com
Received Date: 2023-10-07
Available Online: 2023-12-25
Publish Date: 2024-03-15

Abstract

Abstract

Objective To analyze the correlation between the lung allocation score (LAS) and the risk of early death and complications in patients with idiopathic pulmonary fibrosis (IPF) after lung transplantation. Methods Clinical data of 275 patients with IPF were retrospectively analyzed. The correlation between LAS and the risk of early death in IPF patients after lung transplantation and the correlation between LAS and complications at postoperative 1 year was assessed by univariate and multivariate Cox regression analyses. Results Among 275 recipients, 62, 83, 95 and 108 cases died within postoperative 30, 90, 180 and 365 d, respectively. LAS was correlated with 30-, 90-, 180- and 365-d fatality of IPF patients (all P<0.05), whereas it was not correlated with the incidence of primary graft dysfunction (PGD) and acute kidney injury (AKI) at 365 d after lung transplantation (both P>0.05). Conclusions LAS is correlated with the risk of early death of IPF patients after lung transplantation. While, it is not correlated the incidence of PGD and AKI early after lung transplantation. Special attention should be paid to the effect of comprehensive factors upon PGD and AKI.
- Lung transplantation,
- Lung allocation score,
- Idiopathic pulmonary fibrosis,
- Primary graft dysfunction,
- Acute kidney injury,
- Oxygenation index,
- Bilirubin,
- Central venous pressure

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References(39)

References

[1]	PALLESCHI A, BENAZZI E, ROSSI CF, et al. Lung allocation score system: first Italian experience[J]. Transplant Proc, 2019, 51(1): 190-193. DOI: 10.1016/j.transproceed.2018.02.214.
[2]	GAYEN S, SOSA DF, ZHENG M, et al. Lung transplantation waitlist mortality among sarcoidosis patients by lung allocation score grouping[J]. Transplant Proc, 2023, 55(2): 440-445. DOI: 10.1016/j.transproceed.2023.01.018.
[3]	HULL TD, LEYA GA, AXTELL AL, et al. Lung transplantation for chronic obstructive pulmonary disease: a call to modify the lung allocation score to decrease waitlist mortality[J]. J Thorac Cardiovasc Surg, 2022, 164(4): 1222-1233. DOI: 10.1016/j.jtcvs.2021.11.086.
[4]	KOLAITIS NA, CHEN H, CALABRESE DR, et al. The lung allocation score remains inequitable for patients with pulmonary arterial hypertension, even after the 2015 revision[J]. Am J Respir Crit Care Med, 2023, 207(3): 300-311. DOI: 10.1164/rccm.202201-0217OC.
[5]	练巧燕, 陈奥, 彭桂林, 等. 肺源分配评分在我国肺移植受者中的应用[J]. 中华器官移植杂志, 2020, 41(2): 99-102. DOI: 10.3760/cma.j.issn.0254-1785.2020.02.009. LIAN QY, CHEN A, PENG GL, et al. Application of lung allocation score in Chinese lung transplant recipients[J]. Chin J Organ Transplant, 2020, 41(2): 99-102. DOI: 10.3760/cma.j.issn.0254-1785.2020.02.009.
[6]	胡春晓, 李小杉, 卫栋, 等. 前进中的肺移植事业——我国肺移植发展现状及未来[J]. 器官移植, 2020, 11(2): 204-207. DOI: 10.3969/j.issn.1674-7445.2020.02.005. HU CX, LI XS, WEI D, et al. The development of lung transplantation: current situation and future of lung transplantation in China[J]. Organ Transplant, 2020, 11(2): 204-207. DOI: 10.3969/j.issn.1674-7445.2020.02.005.
[7]	EGAN TM. How should lungs be allocated for transplant?[J]. Semin Respir Crit Care Med, 2018, 39(2): 126-137. DOI: 10.1055/s-0037-1620265.
[8]	EGAN TM, MURRAY S, BUSTAMI RT, et al. Development of the new lung allocation system in the United States[J]. Am J Transplant, 2006, 6(5 Pt 2): 1212-1227. DOI: 10.1111/j.1600-6143.2006.01276.x.
[9]	HIRJI A, ZHAO H, OSPINA MB, et al. Clinical judgment versus lung allocation score in predicting lung transplant waitlist mortality[J]. Clin Transplant, 2020, 34(7): e13870. DOI: 10.1111/ctr.13870.
[10]	YUSEN RD, SHEARON TH, QIAN Y, et al. Lung transplantation in the United States, 1999-2008[J]. Am J Transplant, 2010, 10(4 Pt 2): 1047-1068. DOI: 10.1111/j.1600-6143.2010.03055.x.
[11]	AINGE-ALLEN HW, GLANVILLE AR. Timing it right: the challenge of recipient selection for lung transplantation[J]. Ann Transl Med, 2020, 8(6): 408. DOI: 10.21037/atm.2019.11.61.
[12]	SCHNELLINGER EM, CANTU E, SCHAUBEL DE, et al. Clinical impact of a modified lung allocation score that mitigates selection bias[J]. J Heart Lung Transplant, 2022, 41(11): 1590-1600. DOI: 10.1016/j.healun.2022.08.003.
[13]	AMOR MS, ROSENGARTEN D, SHITENBERG D, et al. Lung transplantation in idiopathic pulmonary fibrosis: risk factors and outcome[J]. Isr Med Assoc J, 2020, 22(12): 741-746.
[14]	LUO C, DUAN Z, XIA Z, et al. Minimum heart rate and mortality after cardiac surgery: retrospective analysis of the Multi-parameter Intelligent Monitoring in Intensive Care (MIMIC-III) database[J]. Sci Rep, 2023, 13(1): 2597. DOI: 10.1038/s41598-023-29703-9.
[15]	胡春兰, 刘民强, 于慧智, 等. 特发性肺纤维化合并肺动脉高压肺移植患者术后早期死亡危险因素分析[J]. 中华危重病急救医学, 2023, 35(2): 124-129. DOI: 10.3760/cma.j.cn121430-20220523-00506. HU CL, LIU MQ, YU HZ, et al. Risk factors of early death after lung transplantation in patients with idiopathic pulmonary fibrosis complicated with pulmonary arterial hypertension[J]. Chin Crit Care Med, 2023, 35(2): 124-129. DOI: 10.3760/cma.j.cn121430-20220523-00506.
[16]	LI SS, MILLER R, TUMIN D, et al. Lung allocation score thresholds prioritize survival after lung transplantation[J]. Chest, 2019, 156(1): 64-70. DOI: 10.1016/j.chest.2019.01.008.
[17]	JAWITZ OK, RAMAN V, BECERRA D, et al. Factors associated with short- versus long-term survival after lung transplant[J]. J Thorac Cardiovasc Surg, 2022, 163(3): 853-860. DOI: 10.1016/j.jtcvs.2020.09.097.
[18]	BRAHMBHATT JM, HEE WAI T, GOSS CH, et al. The lung allocation score and other available models lack predictive accuracy for post-lung transplant survival[J]. J Heart Lung Transplant, 2022, 41(8): 1063-1074. DOI: 10.1016/j.healun.2022.05.008.
[19]	JIN Z, HANA Z, ALAM A, et al. Review 1: lung transplant-from donor selection to graft preparation[J]. J Anesth, 2020, 34(4): 561-574. DOI: 10.1007/s00540-020-02800-z.
[20]	梁佳龙, 陈静瑜, 郑明峰, 等. 肺移植治疗特发性肺纤维化的研究进展[J]. 医学综述, 2022, 28(8): 1573-1578. DOI: 10.3969/j.issn.1006-2084.2022.08.021. LIANG JL, CHEN JY, ZHENG MF, et al. Research progress of lung transplantation in treatment of idiopathic pulmonary fibrosis[J]. Med Recap, 2022, 28(8): 1573-1578. DOI: 10.3969/j.issn.1006-2084.2022.08.021.
[21]	HUNT ML, CANTU E. Primary graft dysfunction after lung transplantation[J]. Curr Opin Organ Transplant, 2023, 28(3): 180-186. DOI: 10.1097/MOT.0000000000001065.
[22]	MINQIANG L, XIAOSHAN L, BO X, et al. A retrospective analysis for risk factors and early prognosis of delayed withdrawal extracorporeal membrane oxygenation after lung transplantation[J]. Transplantation, 2021, 105(4): 867-875. DOI: 10.1097/TP.0000000000003290.
[23]	GIRGIS RE, HADLEY RJ, MURPHY ET. Pulmonary, circulatory and renal considerations in the early postoperative management of the lung transplant recipient[J]. Glob Cardiol Sci Pract, 2023, 2023(3): e202318. DOI: 10.21542/gcsp.2023.18.
[24]	CHACON-ALBERTY L, FERNANDEZ R, JINDRA P, et al. Primary graft dysfunction in lung transplantation: a review of mechanisms and future applications[J]. Transplantation, 2023, 107(8): 1687-1697. DOI: 10.1097/TP.0000000000004503.
[25]	RUSSO MJ, IRIBARNE A, HONG KN, et al. High lung allocation score is associated with increased morbidity and mortality following transplantation[J]. Chest, 2010, 137(3): 651-657. DOI: 10.1378/chest.09-0319.
[26]	EBERLEIN M, GARRITY ER, ORENS JB. Lung allocation in the United States[J]. Clin Chest Med, 2011, 32(2): 213-222. DOI: 10.1016/j.ccm.2011.02.004.
[27]	胡春兰, 于慧智, 王净, 等. 肺移植术后原发性移植物功能障碍的危险因素研究进展[J]. 器官移植, 2021, 12(3): 357-362. DOI: 10.3969/j.issn.1674-7445.2021.03.016. HU CL, YU HZ, WANG J, et al. Research progress on risk factors of primary graft dysfunction after lung transplantation[J]. Organ Transplant, 2021, 12(3): 357-362. DOI: 10.3969/j.issn.1674-7445.2021.03.016.
[28]	QIN J, HU C, CAO X, et al. Development and validation of a nomogram model to predict primary graft dysfunction in patients after lung transplantation based on the clinical factors[J]. Clin Transplant, 2023, 37(10): e15039. DOI: 10.1111/ctr.15039.
[29]	JING L, CHEN W, ZHAO L, et al. Acute kidney injury following adult lung transplantation[J]. Chin Med J (Engl), 2021, 135(2): 172-180. DOI: 10.1097/CM9.0000000000001636.
[30]	BOTROS M, JACKSON K, SINGH P, et al. Insights into early postoperative acute kidney injury following lung transplantation[J]. Clin Transplant, 2022, 36(4): e14568. DOI: 10.1111/ctr.14568.
[31]	王大鹏, 李小杉, 徐忠平, 等. 受者体质量指数对肺移植术后早期预后的影响[J]. 器官移植, 2023, 14(5): 669-675. DOI: 10.3969/j.issn.1674-7445.2023081. WANG DP, LI XS, XU ZP, et al. Effect of body mass index of recipients on early prognosis after lung transplantation[J]. Organ Transplant, 2023, 14(5): 669-675. DOI: 10.3969/j.issn.1674-7445.2023081.
[32]	NATALINI JG, CLAUSEN ES. Critical care management of the lung transplant recipient[J]. Clin Chest Med, 2023, 44(1): 105-119. DOI: 10.1016/j.ccm.2022.10.010.
[33]	Expert Consensus Panel, HARTWIG M, VAN BERKEL V, et al. The American Association for Thoracic Surgery (AATS) 2022 expert consensus document: the use of mechanical circulatory support in lung transplantation[J]. J Thorac Cardiovasc Surg, 2023, 165(1): 301-326. DOI: 10.1016/j.jtcvs.2022.06.024.
[34]	TOYODA T, THOMAE BL, KANDULA V, et al. Primary graft dysfunction grade correlates with acute kidney injury stage after lung transplantation[J]. J Thorac Dis, 2023, 15(7): 3751-3763. DOI: 10.21037/jtd-23-256.
[35]	CANTU E, DIAMOND JM, CEVASCO M, et al. Contemporary trends in PGD incidence, outcomes, and therapies[J]. J Heart Lung Transplant, 2022, 41(12): 1839-1849. DOI: 10.1016/j.healun.2022.08.013.
[36]	KIM NE, KIM CY, KIM SY, et al. Risk factors and mortality of acute kidney injury within 1 month after lung transplantation[J]. Sci Rep, 2021, 11(1): 17399. DOI: 10.1038/s41598-021-96889-1.
[37]	杨航, 焦国慧, 吴波, 等. 呼吸与危重症医学科在肺移植团队中的作用及地位[J]. 中国呼吸与危重监护杂志, 2022, 21(8): 538-540. DOI: 10.7507/1671-6205.202207073. YANG H, JIAO GH, WU B, et al. The role and position of respiratory and critical care medicine in the lung transplantation team[J]. Chin J Respir Crit Care Med, 2022, 21(8): 538-540. DOI: 10.7507/1671-6205.202207073.
[38]	YAMAMOTO H, SUGIMOTO S, SOH J, et al. The prognostic nutritional index is correlated negatively with the lung allocation score and predicts survival after both cadaveric and living-donor lobar lung transplantation[J]. Surg Today, 2021, 51(10): 1610-1618. DOI: 10.1007/s00595-021-02244-2.
[39]	LIANG H, FRITZ AV, MARTIN AK. Perioperative circulatory support and management for lung transplantation: a case-based review[J]. Semin Cardiothorac Vasc Anesth, 2023, 27(1): 68-74. DOI: 10.1177/10892532221134574.

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Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation

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Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation

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