Regulation mechanism of macrophage transition in renal fibrosis

Yang Yanyan; Tao Tao; Luo Pengli

doi:10.3969/j.issn.1674-7445.2023190

Volume 15 Issue 1

Jan. 2024

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Yang Yanyan, Tao Tao, Luo Pengli. Regulation mechanism of macrophage transition in renal fibrosis[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 125-130. doi: 10.3969/j.issn.1674-7445.2023190

Citation:

Yang Yanyan, Tao Tao, Luo Pengli. Regulation mechanism of macrophage transition in renal fibrosis[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 125-130. doi: 10.3969/j.issn.1674-7445.2023190

Citation:

Yang Yanyan, Tao Tao, Luo Pengli. Regulation mechanism of macrophage transition in renal fibrosis[J]. ORGAN TRANSPLANTATION, 2024, 15(1): 125-130. doi: 10.3969/j.issn.1674-7445.2023190

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Regulation mechanism of macrophage transition in renal fibrosis

doi: 10.3969/j.issn.1674-7445.2023190

Yang Yanyan^{1, 2
,},
Tao Tao^{1, 3},
Luo Pengli^{2
,
,}

1.
Research Center for High Altitude Medicine, Qinghai University, Key Laboratory of High Altitude Medicine of Ministry of Education, Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai-Utah Joint Research Key Lab for High Altitude Medicine), Xining 810001, China

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Corresponding author: Luo Pengli, Email: qhlpl2108@163.com
Received Date: 2023-09-26
Available Online: 2023-11-29
Publish Date: 2024-01-11

Abstract

Abstract

Renal fibrosis is a common pathological change from development to end-stage renal diseases in all progressive chronic kidney diseases. Renal fibrosis after kidney transplantation will severely affect the renal graft function. Macrophages are characterized with high heterogeneity and plasticity. During the process of kidney injury, macrophages are recruited, activated and polarized by local microenvironment, and participate in the process of renal tissue injury, repair and fibrosis through multiple mechanisms. Recent studies have shown that macrophages may transit into myofibroblasts and directly participate in the formation of renal fibrosis. This process is known as macrophage-myofibroblast transition. Nevertheless, the regulatory mechanism remains elusive. In this article, the role of macrophages in renal fibrosis, the characteristics of macrophage-myofibroblast transition and the possible regulatory mechanism were reviewed, aiming to provide reference for relevant research of renal fibrosis.
- Renal fibrosis,
- Macrophage,
- Myofibroblast,
- Kidney transplantation,
- Chronic kidney disease,
- End-stage renal disease,
- Transforming growth factor,
- Smad3

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References(43)

References

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Regulation mechanism of macrophage transition in renal fibrosis

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