Attitudes and influencing factors of transplantation-related populations towards kidney xenotransplantation

Xu Ying; Chen Jiahong; He Songzhe; Li Tao; Qi Jinhao; Wang Yi

doi:10.3969/j.issn.1674-7445.2023118

Volume 14 Issue 5

Sep. 2023

Turn off MathJax

Article Contents

Article Navigation > ORGAN TRANSPLANTATION > 2023 > 14(5): 683-690

Xu Ying, Chen Jiahong, He Songzhe, et al. Attitudes and influencing factors of transplantation-related populations towards kidney xenotransplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 683-690. doi: 10.3969/j.issn.1674-7445.2023118

Citation:

PDF( 574 KB)

Attitudes and influencing factors of transplantation-related populations towards kidney xenotransplantation

doi: 10.3969/j.issn.1674-7445.2023118

Xu Ying^1
,,
Chen Jiahong²,
He Songzhe²,
Li Tao²,
Qi Jinhao¹,
Wang Yi^{1, 2, 3
,
,}

1.
International School of Public Health and One Health, Hainan Medical University, Haikou 570100, China

More Information

Corresponding author: Wang Yi, Email: wayne0108@126.com
Received Date: 2023-06-13
Available Online: 2023-07-20
Publish Date: 2023-09-15

Abstract

Abstract

Objective To investigate the attitudes and influencing factors of transplantation-related populations towards kidney xenotransplantation. Methods From June 2022 to January 2023, stratified random sampling was performed from patients awaiting kidney transplantation, patients after kidney transplantation, patients' relatives and medical students. Four hundred subjects were collected from each population and 1600 subjects were investigated using a self-designed questionnaire. Baseline data of the respondents, their attitudes towards kidney xenotransplantation and the reasons of rejecting kidney xenotransplantation were analyzed. The influencing factors of attitudes towards kidney xenotransplantation were also identified. Results A total of 1 493 valid questionnaires were collected, and the questionnaire retrieval rate was 93.31%. About 93.10% of the respondents accepted allogeneic kidney transplantation, and 66.78% had heard of kidney xenotransplantation. Seven hundred and ninety-five respondents suggested that they could accept kidney xenotransplantation "when kidney xenotransplantation and allogeneic kidney transplantation yielded the same results and risks". Six hundred and ninety-eight respondents indicated that they were "unable" or "uncertain" whether they could accept kidney xenotransplantation (χ²=16.409, P=0.001). Among these 698 respondents, the proportion of them who were willing to accept kidney xenotransplantation when they did not meet the conditions of allogeneic kidney transplantation was 10.9%. About 35.8% of respondents were willing to accept kidney xenotransplantation if it yielded less risk and better prognosis compared with allogeneic kidney transplantation. If the time of awaiting kidney xenotransplantation was shorter than that of allogeneic kidney transplantation, 21.2% were willing to accept kidney xenotransplantation. If the cost of kidney xenotransplantation was less than that of allogeneic kidney transplantation, 24.5% of them were willing to accept kidney xenotransplantation. The main reasons of rejecting kidney xenotransplantation included surgical risk and other unknown risks. Multivariate analysis showed that respondents residing in cities and towns for a long period of time, those who accept allogeneic kidney transplantation and those who have heard of kidney xenotransplantation showed more positive attitudes towards kidney xenotransplantation. Conclusions Different transplantation-related populations have different attitudes towards kidney xenotransplantation, and the overall attitudes are positive. Active promotion of kidney xenotransplantation research and carrying out relevant popular science education contribute to improving public attitudes towards the acceptance of kidney xenotransplantation.
- Xenotransplantation,
- Kidney transplantation,
- Organ donation,
- Organ shortage,
- Patient’s relatives,
- Medical student,
- Attitude,
- End stage renal disease

FullText(HTML)

References(35)

References

[1]	鲁瑞, 付鲲. 器官移植供体改革背景下医学专业人群器官捐献意愿的Meta分析[J]. 医学信息, 2022, 35(23): 84-88, 92. DOI: 10.3969/j.issn.1006-1959.2022.23.014. LU R, FU K. Meta-analysis of organ donation willingness of medical professionals under the background of organ transplant donor reform[J]. Med Inf, 2022, 35(23): 84-88, 92. DOI: 10.3969/j.issn.1006-1959.2022.23.014.
[2]	LU T, YANG B, WANG R, et al. Xenotransplantation: current status in preclinical research[J]. Front Immunol, 2020, 10: 3060. DOI: 10.3389/fimmu.2019.03060.
[3]	于佳庆, 方一晽, 方铭慧, 等. 猪肾脏异种移植的研究进展[J]. 吉林大学学报(医学版), 2021, 47(3): 788-795. DOI: 10.13481/j.1671-587X.20210332. YU JQ, FANG YL, FANG MH, et al. Research progress in pig kidney xenotransplantation [J]. J Jilin Univ (Med Edit), 2021, 47(3): 788-795. DOI: 10.13481/j.1671-587X.20210332.
[4]	窦科峰, 张玄. 临床异种器官移植十大问题的思考[J]. 器官移植, 2022, 13(4): 411-416. DOI: 10.3969/j.issn.1674-7445.2022.04.001. DOU KF, ZHANG X. Reflection on 10 problems of clinical xenotransplantation[J]. Organ Transplant, 2022, 13(4): 411-416. DOI: 10.3969/j.issn.1674-7445.2022.04.001.
[5]	RÍOS A, LÓPEZ-NAVAS A, LÓPEZ-LÓPEZ A, et al. The level of acceptance of spanish medical students of the transplantation of solid organs from animals: a stratified and multicentre study[J]. Xenotransplantation, 2015, 22(6): 476-486. DOI: 10.1111/xen.12208.
[6]	PADILLA LA, HURST DJ, JANG K, et al. Racial differences in attitudes to clinical pig organ xenotransplantation[J]. Xenotransplantation, 2021, 28(2): e12656. DOI: 10.1111/xen.12656.
[7]	DELAURA I, ANWAR IJ, LADOWSKI J, et al. Attitudes of patients with renal disease on xenotransplantation: a systematic review[J]. Xenotransplantation, 2023, 30(2): e12794. DOI: 10.1111/xen.12794.
[8]	RODGER D, HURST DJ, COOPER DK. Xenotransplantation: a historical-ethical account of viewpoints[J]. Xenotransplantation, 2023, 30(2): e12797. DOI: 10.1111/xen.12797.
[9]	MENDONÇA L, MARTÍNEZ-ALARCÓN L, RÍOS A, et al. Are veterinary students in favour of xenotranplantation? comparative opinion study in a Brazilian and a Spanish university[J]. Transplant Proc, 2013, 45(3): 1046-1049. DOI: 10.1016/j.transproceed.2013.02.004.
[10]	RÍOS A, LÓPEZ-NAVAS AI, FLORES-MEDINA J, et al. Level of acceptance of solid organ and tissue xenotransplantation among the bolivian population residing in Spain[J]. Transplant Proc, 2018, 50(8): 2300-2302. DOI: 10.1016/j.transproceed.2018.03.103.
[11]	SAFI S, MANSOUR PC, KAADY T, et al. Lebanese medical students' knowledge on and attitude toward xenotransplantation and its ethical issues: a cross-sectional study[J]. Xenotransplantation, 2022, 29(4): e12762. DOI: 10.1111/xen.12762.
[12]	REYNEKE M, KERCKHOF N, DHERWANI R, et al. Should you need an organ… Flemish secondary school students' attitudes toward xenotransplantation and transgenetic organ donation[J]. Xenotransplantation, 2021, 28(6): e12707. DOI: 10.1111/xen.12707.
[13]	RÍOS A, LÓPEZ-NAVAS AI, FLORES-MEDINA J, et al. Acceptance of solid organ xenotransplantation by the ecuadorian population residing in Spain[J]. Transplant Proc, 2020, 52(2): 459-461. DOI: 10.1016/j.transproceed.2019.11.044.
[14]	RÍOS A, LÓPEZ-GÓMEZ S, BELMONTE J, et al. Acceptance of the xenotransplantation of organs among the population of the Spanish Gypsy Ethnic Group[J]. Transplant Proc, 2019, 51(2): 293-295. DOI: 10.1016/j.transproceed.2018.10.013.
[15]	RÍOS A, LÓPEZ-NAVAS AI, FLORES-MEDINA J, et al. Are dominicans in favor of xenotransplantation? a study of the attitude of dominican immigrants residing in Spain and the United States[J]. Transplant Proc, 2018, 50(8): 2296-2299. DOI: 10.1016/j.transproceed.2018.02.193.
[16]	PADILLA LA, RHODES L, SORABELLA RA, et al. Attitudes toward xenotransplantation: a survey of parents and pediatric cardiac providers[J]. Pediatr Transplant, 2021, 25(2): e13851. DOI: 10.1111/petr.13851.
[17]	RÍOS A, LÓPEZ-NAVAS AI, MARTÍNEZ-ALARCÓN L, et al. Acceptance of organ xenotransplantation among Latin American immigrants resident in the United States[J]. Xenotransplantation, 2016, 23(4): 269-278. DOI: 10.1111/xen.12250.
[18]	RÍOS A, LÓPEZ-NAVAS AI, CARRILLO J, et al. Is the population of Santiago de Cuba sensitized to xenotransplantation? a multivariate analysis[J]. Transplant Proc, 2020, 52(2): 484-486. DOI: 10.1016/j.transproceed.2019.11.046.
[19]	HURST DJ, PADILLA LA, COOPER DK, et al. The attitudes of religious group leaders towards xenotransplantation: a focus group study[J]. Xenotransplantation, 2022, 29(5): e12777. DOI: 10.1111/xen.12777.
[20]	RÍOS A, CARRILLO J, LÓPEZ-NAVAS AI, et al. Population of Senegal residents in Spain: acceptance of organ xenotransplantation[J]. Transplant Proc, 2020, 52(2): 473-475. DOI: 10.1016/j.transproceed.2019.11.045.
[21]	RÍOS A, LÓPEZ-NAVAS AI, FLORES-MEDINA J, et al. Puerto Rican population residing in Florida: attitude towards organ xenotransplantation[J]. Transplant Proc, 2020, 52(2): 455-458. DOI: 10.1016/j.transproceed.2019.12.018.
[22]	FRAUX C, MUÑOZ SASTRE MT, KPANAKE L, et al. French people's views regarding xenotransplantation[J]. Transplant Proc, 2021, 53(2): 529-538. DOI: 10.1016/j.transproceed.2020.08.032.
[23]	MARTÍNEZ-ALARCÓN L, RÍOS A, SANTAINÉS-BORREDÁ E, et al. Student nurses at Spanish universities and their attitude toward xenotransplantation[J]. Xenotransplantation, 2019, 26(3): e12507. DOI: 10.1111/xen.12507.
[24]	PADILLA LA, HURST D, LOPEZ R, et al. Attitudes to clinical pig kidney xenotransplantation among medical providers and patients[J]. Kidney360, 2020, 1(7): 657-662. DOI: 10.34067/KID.0002082020.
[25]	王振迪, 夏秋翔, 曾宪鹏, 等. 公众对异种移植态度的问卷调查分析[J]. 中华器官移植杂志, 2022, 43(9): 536-543. DOI: 10.3760/cma.j.cn421203-20220304-00033. WANG ZD, XIA QX, ZENG XP, et al. A public attitude survey on organ xenotransplantation[J]. Chin J Organ Transplant, 2022, 43(9): 536-543. DOI: 10.3760/cma.j.cn421203-20220304-00033.
[26]	陈忠华, 孙煦勇. 临床异种移植百年进展 [J]. 广西科学, 2022, 29(3): 411-414, 422. DOI: 10.13656/j.cnki.gxkx.20220720.002. CHEN ZH, SUN XY. One hundred years of progress in clinical xenotransplantation [J]. Guangxi Sci, 2022, 29(3): 411-414, 422. DOI: 10.13656/j.cnki.gxkx.20220720.002.
[27]	MARTÍNEZ-ALARCÓN L, RÍOS A, PONS JA, et al. Attitudinal study of organ xenotransplantation in patients on the kidney and liver transplant waiting list in a country with a high rate of deceased donation[J]. Xenotransplantation, 2011, 18(3): 168-175. DOI: 10.1111/j.1399-3089.2011.00637.x.
[28]	董晶莹, 李婧波, 韩春艳, 等. 血液透析和腹膜透析治疗老年终末期肾病的临床疗效[J]. 中国老年学杂志, 2021, 41(11): 2353-2356. DOI: 10.3969/j.issn.1005-9202.2021.11.035. DONG JY, LI JB, HAN CY, et al. Clinical efficacy of hemodialysis and peritoneal dialysis in the treatment of elderly end-stage renal disease[J]. Chin J Gerontol, 2021, 41(11): 2353-2356. DOI: 10.3969/j.issn.1005-9202.2021.11.035.
[29]	林韦彤, 刘立芳, 万晶晶, 等. 肾移植受者恐惧疾病进展现状及影响因素研究[J]. 中华护理杂志, 2022, 57(1): 73-78. DOI: 10.3761/j.issn.0254-1769.2022.01.011. LIN WT, LIU LF, WAN JJ, et al. The status and factors associated with fear of progression in recipients of renal transplantation[J]. Chin J Nurs, 2022, 57(1): 73-78. DOI: 10.3761/j.issn.0254-1769.2022.01.011.
[30]	郝艳华, 姜亚芳. 维持性血液透析患者症状经历的调查研究[J]. 中华护理杂志, 2016, 51(3): 299-303. DOI: 10.3761/j.issn.0254-1769.2016.03.008. HAO YH, JIANG YF. Symptom experiences among maintenance hemodialysis patients: a cross-sectional study[J]. Chin J Nurs, 2016, 51(3): 299-303. DOI: 10.3761/j.issn.0254-1769.2016.03.008.
[31]	凌铭培, 叶益舟, 王丽梅. 不同透析方式对尿毒症患者肾功能炎症细胞因子及预后的影响[J]. 实用医技杂志, 2022, 29(11): 1191-1194. DOI: 10.19522/j.cnki.1671-5098.2022.11.018. LING MP, YE YZ, WANG LM. Effects of different dialysis methods on inflammatory cytokines in renal function and prognosis of uremia patients[J]. J Pract Med Tech, 2022, 29(11): 1191-1194. DOI: 10.19522/j.cnki.1671-5098.2022.11.018.
[32]	曾颖, 姜小梅, 刘鹏程,等. 维持性血液透析患者不安腿综合征危险因素分析[J]. 实用医学杂志, 2022, 38(1): 12-17. DOI: 10.3969/j.issn.1006-5725.2022.01.003. ZENG Y, JIANG XM, LIU PC, et al. The risk factors of restless legs syndrome in maintenance hemodialysis patients[J]. J Pract Med, 2022, 38(1): 12-17. DOI: 10.3969/j.issn.1006-5725.2022.01.003.
[33]	胡风侠. 肾移植后受者感染危险因素调查及直接经济负担研究[D]. 西安: 空军军医大学, 2018.
[34]	MITCHELL C, LIPPS A, PADILLA L, et al. Meta-analysis of public perception toward xenotransplantation[J]. Xenotransplantation, 2020, 27(4): e12583. DOI: 10.1111/xen.12583.
[35]	RÍOS A, LÓPEZ-NAVAS AI, FLORES-MEDINA J, et al. Nicaraguan population residing in Florida attitude toward different types of organ donation[J]. Transplant Proc, 2020, 52(2): 452-454. DOI: 10.1016/j.transproceed.2019.11.043.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1) / Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (272) PDF downloads(48)

Attitudes and influencing factors of transplantation-related populations towards kidney xenotransplantation

doi: 10.3969/j.issn.1674-7445.2023118

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Attitudes and influencing factors of transplantation-related populations towards kidney xenotransplantation

doi: 10.3969/j.issn.1674-7445.2023118

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content