Volume 14 Issue 5
Sep.  2023
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Zhang Shuyu, Li Yuehong. Research progress on kidney transplantation rejection associated with non-HLA antibody[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 730-735. doi: 10.3969/j.issn.1674-7445.2023101
Citation: Zhang Shuyu, Li Yuehong. Research progress on kidney transplantation rejection associated with non-HLA antibody[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 730-735. doi: 10.3969/j.issn.1674-7445.2023101

Research progress on kidney transplantation rejection associated with non-HLA antibody

doi: 10.3969/j.issn.1674-7445.2023101
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  • Corresponding author: Li Yuehong, Email: lyha01051@btch.edu.cn
  • Received Date: 2023-05-10
  • Accepted Date: 2023-07-07
  • Available Online: 2023-07-20
  • Publish Date: 2023-09-15
  • Human leukocyte antigen (HLA) is a product encoded by HLA gene complex, which is located on the short arm of chromosome 6 and is the main target of alloimmunity. However, positive HLA antibody is not responsible for all kinds of rejections in kidney transplantation. Non-HLA antibody is the product of donor gene expression in allogeneic kidney transplantation. Intraoperative ischemia-reperfusion injury, the interaction between alloimmunity and autoimmunity and the mediation of extracellular vesicles may trigger immune system response and promote the production of non-HLA antibody. Multiple studies have demonstrated that non-HLA antibody is an important factor of inducing rejection and affecting the outcomes of kidney transplantation. Consequently, the types and formation mechanism of non-HLA antibody in kidney transplantation were reviewed, and research progress on kidney transplantation rejection associated with non-HLA antibody was summarized, aiming to provide reference for in-depth study of kidney transplantation rejection associated with non-HLA antibody.

     

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