Role and prospect of ferroptosis in ischemia-reperfusion injury during organ transplantation

Li Jiawei; Xu Hongyang

doi:10.3969/j.issn.1674-7445.2023058

Volume 14 Issue 5

Sep. 2023

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Li Jiawei, Xu Hongyang. Role and prospect of ferroptosis in ischemia-reperfusion injury during organ transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 662-668. doi: 10.3969/j.issn.1674-7445.2023058

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Role and prospect of ferroptosis in ischemia-reperfusion injury during organ transplantation

doi: 10.3969/j.issn.1674-7445.2023058

Li Jiawei,
Xu Hongyang^,

Department of Intensive Care Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214000, China

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Corresponding author: Xu Hongyang, Email: xhy1912@aliyun.com
Received Date: 2023-04-21
Available Online: 2023-07-20
Publish Date: 2023-09-15

Abstract

Abstract

Ferroptosis is a newly-emerged pattern of programmed cell death discovered in recent years, which is defined as iron-dependent programmed necrosis mediated by lipid peroxidation damage. As a conservative procedure, ferroptosis plays a vital role in the development and diseases of multiple organisms including plants and animals. Since ferroptosis was first reported in 2012, growing interests have been diverted to the process of ferroptosis and its role in disease treatment. Ischemia-reperfusion injury is a common pathological process during organ transplantation, and ferroptosis is considered as one of the main patterns inducing ischemia-reperfusion injury. Consequently, the definition, regulatory mechanism and the mechanisms of ferroptosis in ischemia-reperfusion injury after kidney, liver, heart and lung transplantations were reviewed, aiming to provide theoretical basis for the prevention and treatment of ischemia-reperfusion injury in organ transplantation.
- Ferroptosis,
- Organ transplantation,
- Ischemia-reperfusion injury,
- Organ protection,
- Oxidative damage,
- Iron metabolism,
- Glutathione,
- Glutathione peroxidase 4

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References(50)

References

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Role and prospect of ferroptosis in ischemia-reperfusion injury during organ transplantation

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Role and prospect of ferroptosis in ischemia-reperfusion injury during organ transplantation

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