Epidemiological distribution of donor infection and drug resistance of main pathogens in organ donation after citizen's death

Fan Pengfei; Wang Qingping; Wang Honghai; Zhang Weiye

doi:10.3969/j.issn.1674-7445.2022.02.011

Volume 13 Issue 2

Mar. 2022

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Fan Pengfei, Wang Qingping, Wang Honghai, et al. Epidemiological distribution of donor infection and drug resistance of main pathogens in organ donation after citizen's death[J]. ORGAN TRANSPLANTATION, 2022, 13(2): 225-231. doi: 10.3969/j.issn.1674-7445.2022.02.011

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Epidemiological distribution of donor infection and drug resistance of main pathogens in organ donation after citizen's death

doi: 10.3969/j.issn.1674-7445.2022.02.011

Second Department of Intensive Care, Tianjin First Central Hospital, Tianjin 300192, China

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Corresponding author: Zhang Weiye, Email: zwy7795@vip.sina.com
Received Date: 2021-11-09
Available Online: 2022-03-18
Publish Date: 2022-03-15

Abstract

Abstract

Objective To analyze the distribution characteristics and drug resistance of pathogens in infected donors from organ donation after citizen's death. Methods Clinical data of 465 potential donors from organ donation after citizen's death were retrospectively analyzed. The airway secretion, urine and blood samples of all donors were cultured. The infection rate of the donors, the source and composition ratio of pathogens were summarized. The drug resistance of main Gram-negative and Gram-positive pathogens was analyzed. Results Among 465 donors, 330 cases were infected and the infection rate was 71.0%. Among the positive culture samples of all donors, lower respiratory tract samples accounted for 63.8%(292/458), 18.6%(85/458) for blood samples and 17.7%(81/458) for urine samples. A total of 512 pathogens were isolated, including 75.0%(384/512) of Gram-negative pathogens, 18.2%(93/512) of Gram-positive pathogens followed by 6.8%(35/512) of fungi. Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii were the most common Gram-negative pathogens. Klebsiella pneumoniae was sensitive to quinolones, compound preparations containing β-lactamase inhibitor (piperacillin-tazobactam, cefoperazone sodium-sulbactam sodium) and carbapenem antibiotics, whereas less sensitive to cephalosporins. Pseudomonas aeruginosa was sensitive to β-lactams, quinolones and aminoglycosides. Acinetobacter baumannii was sensitive to polymyxin, tigecycline and amikacin, whereas resistant to the other antibiotics. No Gram-positive pathogens was resistant to vancomycin, linezolid and teicoplanin. Staphylococcus aureus and coagulase-negative staphylococci were the most commonly isolated Gram-positive pathogens, which yielded resistance rates of 36% and 87% to oxacillin sodium, and were generally resistant to penicillin and erythromycin. The resistance rate of Enterococcus faecalis to quinolones and erythromycin exceeded 90%, and 55% for high-concentration gentamicin. Conclusions The infection rate of organ donors from organ donation after citizen's death is relatively high, and the main infection site is lung. Gram-negative pathogens are the most commonly isolated strains, and certain strains tend to exhibit multiple drug resistance.
- Organ donation after citizen's death,
- Donor-derived infection,
- Pathogen,
- Colonization,
- Drug resistance,
- Coagulase-negative staphylococci,
- Klebsiella pneumoniae,
- Pseudomonas aeruginosa,
- Acinetobacter baumannii,
- Staphylococcus aureus,
- Enterococcus faecium

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Epidemiological distribution of donor infection and drug resistance of main pathogens in organ donation after citizen's death

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Epidemiological distribution of donor infection and drug resistance of main pathogens in organ donation after citizen's death

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