Volume 13 Issue 2
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Chang Sheng, Dai Linrui. Research progress on application of machine perfusion in quality maintenance of donor kidney from organ donation after citizen's death[J]. ORGAN TRANSPLANTATION, 2022, 13(2): 195-205. doi: 10.3969/j.issn.1674-7445.2022.02.007
Citation: Chang Sheng, Dai Linrui. Research progress on application of machine perfusion in quality maintenance of donor kidney from organ donation after citizen's death[J]. ORGAN TRANSPLANTATION, 2022, 13(2): 195-205. doi: 10.3969/j.issn.1674-7445.2022.02.007
shu

Research progress on application of machine perfusion in quality maintenance of donor kidney from organ donation after citizen's death

doi: 10.3969/j.issn.1674-7445.2022.02.007

  • Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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  • Corresponding author: Chang Sheng, Email: changsheng@hust.edu.cn
  • Received Date: 2021-12-25
    Available Online: 2022-03-18
  • Publish Date: 2022-03-15
    Abstract
  • Organ donation after citizen's death has become the main source of organ donation in China. However, the complexity of donor quality and the increasing proportion of expanded criteria donor (ECD) exert significant impact upon the availability of donor kidney and the long-term prognosis of recipients after kidney transplantation. Strengthening the quality maintenance and evaluation of donor kidney is of great significance for improving the quality of donor kidney, increasing the procurement and utilization of donor kidney and prolonging the long-term survival of recipients and kidney allografts. As one of the major approaches of organ preservation, machine perfusion preservation may not only prolong the preservation time and improve the quality of donor kidney, but also play a critical role in the repair and function evaluation of donor kidney. Based on literature review, several hot issues, corresponding treatment strategies and research progress on machine perfusion in the quality maintenance of donor kidney from organ donation after citizen's death were reviewed in this article, aiming to provide reference for selecting the optimal preservation method of donor kidney and enhancing the quality and utilization rate of ECD donor kidney.

     

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  • [1]
    黄洁夫. 中国人体器官分配与共享[M]//黄洁夫. 中国器官移植发展报告(2019). 北京: 清华大学出版社, 2020: 18-19.
    [2]
    FELLMANN M, BALSSA L, CLÉMENT E, et al. Postoperative complications and long-term outcomes of transplantation with expended criteria donors transplants[J]. Prog Urol, 2020, 30(12): 655-662. DOI: 10.1016/j.purol.2020.04.019.
    [3]
    TAYLOR MJ, BAICU SC. Current state of hypothermic machine perfusion preservation of organs: the clinical perspective[J]. Cryobiology, 2010, 60(3 Suppl): S20-S35. DOI: 10.1016/j.cryobiol.2009.10.006.
    [4]
    KATHS JM, PAUL A, ROBINSON LA, et al. Ex vivo machine perfusion for renal graft preservation[J]. Transplant Rev (Orlando), 2018, 32(1): 1-9. DOI: 10.1016/j.trre.2017.04.002.
    [5]
    BELZER FO, SOUTHARD JH. Principles of solid-organ preservation by cold storage[J]. Transplantation, 1988, 45(4): 673-676. DOI: 10.1097/00007890-198804000-00001.
    [6]
    MATSUOKA L, SHAH T, ASWAD S, et al. Pulsatile perfusion reduces the incidence of delayed graft function in expanded criteria donor kidney transplantation[J]. Am J Transplant, 2006, 6(6): 1473-1478. DOI: 10.1111/j.1600-6143.2006.01323.x.
    [7]
    HENRY SD, GUARRERA JV. Protective effects of hypothermic ex vivo perfusion on ischemia/reperfusion injury and transplant outcomes[J]. Transplant Rev (Orlando), 2012, 26(2): 163-175. DOI: 10.1016/j.trre.2011.09.001.
    [8]
    BRAT A, DE VRIES KM, VAN HEURN EWE, et al. Hypothermic machine perfusion as a national standard preservation method for deceased donor kidneys[J]. Transplantation, 2021, DOI: 10.1097/TP.0000000000003845 [Epub ahead of print].
    [9]
    TINGLE SJ, FIGUEIREDO RS, MOIR JA, et al. Machine perfusion preservation versus static cold storage for deceased donor kidney transplantation[J]. Cochrane Database Syst Rev, 2019, 3(3): CD011671. DOI: 10.1002/14651858.CD011671.pub2.
    [10]
    PENG P, DING Z, HE Y, et al. Hypothermic machine perfusion versus static cold storage in deceased donor kidney transplantation: a systematic review and Meta-analysis of randomized controlled trials[J]. Artif Organs, 2019, 43(5): 478-489. DOI: 10.1111/aor.13364.
    [11]
    RUIZ-HERNÁNDEZ M, GÓMEZ-DOS SANTOS V, DÍAZ-PÉREZ D, et al. Experience with hypothermic machine perfusion in expanded criteria donors: functional outcomes[J]. Transplant Proc, 2019, 51(2): 303-306. DOI: 10.1016/j.transproceed.2018.09.020.
    [12]
    DION MS, MCGREGOR TB, MCALISTER VC, et al. Hypothermic machine perfusion improves Doppler ultrasonography resistive indices and long-term allograft function after renal transplantation: a single-centre analysis[J]. BJU Int, 2015, 116(6): 932-937. DOI: 10.1111/bju.12960.
    [13]
    RIJKSE E, IJZERMANS JN, MINNEE RC. Machine perfusion in abdominal organ transplantation: current use in the Netherlands[J]. World J Transplant, 2020, 10(1): 15-28. DOI: 10.5500/wjt.v10.i1.15.
    [14]
    SMITH TB, NICHOLSON ML, HOSGOOD SA. Advances in hypothermic and normothermic perfusion in kidney transplantation[J]. Transplantology, 2021, 2(4): 460-477.
    [15]
    BELLINI MI, TORTORICI F, AMABILE MI, et al. Assessing kidney graft viability and its cells metabolism during machine perfusion[J]. Int J Mol Sci, 2021, 22(3): 1121. DOI: 10.3390/ijms22031121.
    [16]
    JOCHMANS I, MOERS C, SMITS JM, et al. The prognostic value of renal resistance during hypothermic machine perfusion of deceased donor kidneys[J]. Am J Transplant, 2011, 11(10): 2214-2220. DOI: 10.1111/j.1600-6143.2011.03685.x.
    [17]
    YUSHKOV YY, STERN J, YING A, et al. Identifying risk factors in renal allografts before transplant: machine-measured renal resistance and posttransplant allograft survival[J]. Prog Transplant, 2012, 22(2): 175-182. DOI: 10.7182/pit2012968.
    [18]
    PATEL SK, PANKEWYCZ OG, NADER ND, et al. Prognostic utility of hypothermic machine perfusion in deceased donor renal transplantation[J]. Transplant Proc, 2012, 44(7): 2207-2212. DOI: 10.1016/j.transproceed.2012.07.129.
    [19]
    PATEL SK, PANKEWYCZ OG, WEBER-SHRIKANT E, et al. Effect of increased pressure during pulsatile pump perfusion of deceased donor kidneys in transplantation[J]. Transplant Proc, 2012, 44(7): 2202-2206. DOI: 10.1016/j.transproceed.2012.07.109.
    [20]
    PARIKH CR, HALL IE, BHANGOO RS, et al. Associations of perfusate biomarkers and pump parameters with delayed graft function and deceased donor kidney allograft function[J]. Am J Transplant, 2016, 16(5): 1526-1539. DOI: 10.1111/ajt.13655.
    [21]
    GUZZI F, KNIGHT SR, PLOEG RJ, et al. A systematic review to identify whether perfusate biomarkers produced during hypothermic machine perfusion can predict graft outcomes in kidney transplantation[J]. Transpl Int, 2020, 33(6): 590-602. DOI: 10.1111/tri.13593.
    [22]
    FAUCHER Q, ALARCAN H, SAUVAGE F-L, et al. Perfusate metabolomics content and tubular transporters expression during kidney graft preservation by hypothermic machine perfusion[EB/OL]. [2021-12-15]. https://www.medrxiv.org/content/10.1101/2021.09.27.21264167v2.
    [23]
    GOWERS SAN, HAMAOUI K, VALLANT N, et al. An improved rapid sampling microdialysis system for human and porcine organ monitoring in a hospital setting[J]. Anal Methods, 2018, 10(44): 5273-5281. DOI: 10.1039/c8ay01807c.
    [24]
    KONKEL B, LAVIN C, WU TT, et al. Fully automated analysis of OCT imaging of human kidneys for prediction of post-transplant function[J]. Biomed Opt Express, 2019, 10(4): 1794-1821. DOI: 10.1364/BOE.10.001794.
    [25]
    STEICHEN C, GIRAUD S, BON D, et al. Barriers and advances in kidney preservation[J]. Biomed Res Int, 2018: 9206257. DOI: 10.1155/2018/9206257.
    [26]
    MEISTER FA, CZIGANY Z, RIETZLER K, et al. Decrease of renal resistance during hypothermic oxygenated machine perfusion is associated with early allograft function in extended criteria donation kidney transplantation[J]. Sci Rep, 2020, 10(1): 17726. DOI: 10.1038/s41598-020-74839-7.
    [27]
    JOCHMANS I, BRAT A, DAVIES L, et al. Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial[J]. Lancet, 2020, 396(10263): 1653-1662. DOI: 10.1016/S0140-6736(20)32411-9.
    [28]
    ROUSSELOT M, DELPY E, DRIEU LA ROCHELLE C, et al. Arenicola marina extracellular hemoglobin: a new promising blood substitute[J]. Biotechnol J, 2006, 1(3): 333-345. DOI: 10.1002/biot.200500049.
    [29]
    KASIL A, GIRAUD S, COUTURIER P, et al. Individual and combined impact of oxygen and oxygen transporter supplementation during kidney machine preservation in a porcine preclinical kidney transplantation model[J]. Int J Mol Sci, 2019, 20(8): 1992. DOI: 10.3390/ijms20081992.
    [30]
    LE MEUR Y, BADET L, ESSIG M, et al. First-in-human use of a marine oxygen carrier (M101) for organ preservation: a safety and proof-of-principle study[J]. Am J Transplant, 2020, 20(6): 1729-1738. DOI: 10.1111/ajt.15798.
    [31]
    HOUTZAGER JHE, HEMELRIJK SD, POST ICJH, et al. The use of the oxygenated AirdriveTM machine perfusion system in kidney graft preservation: a clinical pilot study[J]. Eur Surg Res, 2020, 61(6): 153-162. DOI: 10.1159/000513493.
    [32]
    BISSOLATI M, GAZZETTA PG, CALDARA R, et al. Renal resistance trend during hypothermic machine perfusion is more predictive of postoperative outcome than biopsy score: preliminary experience in 35 consecutive kidney transplantations[J]. Artif Organs, 2018, 42(7): 714-722. DOI: 10.1111/aor.13117.
    [33]
    BISSOLATI M, CERCHIONE R, TERULLA A, et al. Renal resistance trend during hypothermic machine perfusion correlates with preimplantation biopsy score in transplantation of kidneys from extended criteria donors[J]. Transplant Proc, 2021, 53(6): 1823-1830. DOI: 10.1016/j.transproceed.2021.03.036.
    [34]
    DE BEULE J, JOCHMANS I. Kidney perfusion as an organ quality assessment tool-are we counting our chickens before they have hatched?[J]. J Clin Med, 2020, 9(3): 879. DOI: 10.3390/jcm9030879.
    [35]
    DIRITO JR, HOSGOOD SA, TIETJEN GT, et al. The future of marginal kidney repair in the context of normothermic machine perfusion[J]. Am J Transplant, 2018, 18(10): 2400-2408. DOI: 10.1111/ajt.14963.
    [36]
    RIJKSE E, BOUARI S, KIMENAI HJAN, et al. Additional normothermic machine perfusion versus hypothermic machine perfusion in suboptimal donor kidney transplantation: protocol of a randomized, controlled, open-label trial[J]. Int J Surg Protoc, 2021, 25(1): 227-237. DOI: 10.29337/ijsp.165.
    [37]
    WEISSENBACHER A, HUANG H, SURIK T, et al. Urine recirculation prolongs normothermic kidney perfusion via more optimal metabolic homeostasis-a proteomics study[J]. Am J Transplant, 2021, 21(5): 1740-1753. DOI: 10.1111/ajt.16334.
    [38]
    CHANDAK P, PHILLIPS BL, UWECHUE R, et al. Dissemination of a novel organ perfusion technique: ex vivo normothermic perfusion of deceased donor kidneys[J]. Artif Organs, 2019, 43(11): E308-E319. DOI: 10.1111/aor.13499.
    [39]
    HAMEED AM, LU DB, PATRICK E, et al. Brief normothermic machine perfusion rejuvenates discarded human kidneys[J]. Transplant Direct, 2019, 5(11): e502. DOI: 10.1097/TXD.0000000000000944.
    [40]
    WEISSENBACHER A, LO FARO L, BOUBRIAK O, et al. Twenty-four-hour normothermic perfusion of discarded human kidneys with urine recirculation[J]. Am J Transplant, 2019, 19(1): 178-192. DOI: 10.1111/ajt.14932.
    [41]
    RIJKSE E, DE JONGE J, KIMENAI HJAN, et al. Safety and feasibility of 2 h of normothermic machine perfusion of donor kidneys in the Eurotransplant Senior Program[J]. BJS Open, 2021, 5(1): zraa024. DOI: 10.1093/bjsopen/zraa024.
    [42]
    KABAGAMBE SK, PALMA IP, SMOLIN Y, et al. Combined ex vivo hypothermic and normothermic perfusion for assessment of high-risk deceased donor human kidneys for transplantation[J]. Transplantation, 2019, 103(2): 392-400. DOI: 10.1097/TP.0000000000002299.
    [43]
    HOSGOOD SA, NICHOLSON ML. First in man renal transplantation after ex vivo normothermic perfusion[J]. Transplantation, 2011, 92(7): 735-738. DOI: 10.1097/TP.0b013e31822d4e04.
    [44]
    HOSGOOD SA, BARLOW AD, HUNTER JP, et al. Ex vivo normothermic perfusion for quality assessment of marginal donor kidney transplants[J]. Br J Surg, 2015, 102(11): 1433-1440. DOI: 10.1002/bjs.9894.
    [45]
    HE X, CHEN G, ZHU Z, et al. The first case of ischemia-free kidney transplantation in humans[J]. Front Med (Lausanne), 2019, 6: 276. DOI: 10.3389/fmed.2019.00276.
    [46]
    FERDINAND JR, HOSGOOD SA, MOORE T, et al. Cytokine absorption during human kidney perfusion reduces delayed graft function-associated inflammatory gene signature[J]. Am J Transplant, 2021, 21(6): 2188-2199. DOI: 10.1111/ajt.16371.
    [47]
    BRASILE L, HENRY N, ORLANDO G, et al. Potentiating renal regeneration using mesenchymal stem cells[J]. Transplantation, 2019, 103(2): 307-313. DOI: 10.1097/TP.0000000000002455.
    [48]
    ABURAWI MM, FONTAN FM, KARIMIAN N, et al. Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion[J]. Am J Transplant, 2019, 19(10): 2814-2824. DOI: 10.1111/ajt.15375.
    [49]
    MINOR T, VON HORN C, PAUL A. Role of erythrocytes in short-term rewarming kidney perfusion after cold storage[J]. Artif Organs, 2019, 43(6): 584-592. DOI: 10.1111/aor.13403.
    [50]
    MINOR T, VON HORN C, GALLINAT A, et al. First-in-man controlled rewarming and normothermic perfusion with cell-free solution of a kidney prior to transplantation[J]. Am J Transplant, 2020, 20(4): 1192-1195. DOI: 10.1111/ajt.15647.
    [51]
    DIRITO JR, HOSGOOD SA, RESCHKE M, et al. Lysis of cold-storage-induced microvascular obstructions for ex vivo revitalization of marginal human kidneys[J]. Am J Transplant, 2021, 21(1): 161-173. DOI: 10.1111/ajt.16148.
    [52]
    TIETJEN GT, HOSGOOD SA, DIRITO J, et al. Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys[J]. Sci Transl Med, 2017, 9(418): eaam6764. DOI: 10.1126/scitranslmed.aam6764.
    [53]
    ZHAO L, HU C, HAN F, et al. Combination of mesenchymal stromal cells and machine perfusion is a novel strategy for organ preservation in solid organ transplantation[J]. Cell Tissue Res, 2021, 384(1): 13-23. DOI: 10.1007/s00441-020-03406-3.
    [54]
    THOMPSON ER, CONNELLY C, ALI S, et al. Cell therapy during machine perfusion[J]. Transpl Int, 2021, 34(1): 49-58. DOI: 10.1111/tri.13780.
    [55]
    SHAPEY IM, MUIESAN P. Regional perfusion by extracorporeal membrane oxygenation of abdominal organs from donors after circulatory death: a systematic review[J]. Liver Transpl, 2013, 19(12): 1292-1303. DOI: 10.1002/lt.23771.
    [56]
    DEL RÍO F, ANDRÉS A, PADILLA M, et al. Kidney transplantation from donors after uncontrolled circulatory death: the Spanish experience[J]. Kidney Int, 2019, 95(2): 420-428. DOI: 10.1016/j.kint.2018.09.014.
    [57]
    ALVAREZ-RODRIGUEZ J, DEL BARRIO-YESA R, TORRENTE-SIERRA J, et al. Posttransplant long-term outcome of kidneys obtained from asystolic donors maintained under extracorporeal cardiopulmonary bypass[J]. Transplant Proc, 1995, 27(5): 2903-2904.
    [58]
    COLL E, MIÑAMBRES E, SÁNCHEZ-FRUCTUOSO A, et al. Uncontrolled donation after circulatory death: a unique opportunity[J]. Transplantation, 2020, 104(8): 1542-1552. DOI: 10.1097/TP.0000000000003139.
    [59]
    PADILLA M, COLL E, FERNÁNDEZ-PÉREZ C, et al. Improved short-term outcomes of kidney transplants in controlled donation after the circulatory determination of death with the use of normothermic regional perfusion[J]. Am J Transplant, 2021, 21(11): 3618-3628. DOI: 10.1111/ajt.16622.
    [60]
    ARTILES MEDINA A, BURGOS REVILLA FJ, ÁLVAREZ NADAL M, et al. Comparison of in situ preservation techniques for kidneys from donors after circulatory death: a systematic review and Meta-analysis[J]. Transl Androl Urol, 2021, 10(8): 3286-3299. DOI: 10.21037/tau-21-236.
    [61]
    SHAPEY IM, SUMMERS A, AUGUSTINE T, et al. Systematic review to assess the possibility of return of cerebral and cardiac activity after normothermic regional perfusion for donors after circulatory death[J]. Br J Surg, 2019, 106(3): 174-180. DOI: 10.1002/bjs.11046.
    [62]
    HESSHEIMER AJ, BILLAULT C, BARROU B, et al. Hypothermic or normothermic abdominal regional perfusion in high-risk donors with extended warm ischemia times: impact on outcomes?[J]. Transpl Int, 2015, 28(6): 700-707. DOI: 10.1111/tri.12344.
    [63]
    BUTLER AJ, RANDLE LV, WATSON CJ. Normothermic regional perfusion for donation after circulatory death without prior heparinization[J]. Transplantation, 2014, 97(12): 1272-1278. DOI: 10.1097/TP.0000000000000082.
    [64]
    ROJAS-PEÑA A, SALL LE, GRAVEL MT, et al. Donation after circulatory determination of death: the University of Michigan experience with extracorporeal support[J]. Transplantation, 2014, 98(3): 328-334. DOI: 10.1097/TP.0000000000000070.
    [65]
    MIÑAMBRES E, SUBERVIOLA B, DOMINGUEZ-GIL B, et al. Improving the outcomes of organs obtained from controlled donation after circulatory death donors using abdominal normothermic regional perfusion[J]. Am J Transplant, 2017, 17(8): 2165-2172. DOI: 10.1111/ajt.14214.
    [66]
    HOSGOOD SA, BROWN RJ, NICHOLSON ML. Advances in kidney preservation techniques and their application in clinical practice[J]. Transplantation, 2021, 105(11): e202-e214. DOI: 10.1097/TP.0000000000003679.
    [67]
    REZNIK ON, SKVORTSOV AE, REZNIK AO, et al. Uncontrolled donors with controlled reperfusion after sixty minutes of asystole: a novel reliable resource for kidney transplantation[J]. PLoS One, 2013, 8(5): e64209. DOI: 10.1371/journal.pone.0064209.
    [68]
    MOLINA M, GUERRERO-RAMOS F, FERNÁNDEZ-RUIZ M, et al. Kidney transplant from uncontrolled donation after circulatory death donors maintained by nECMO has long-term outcomes comparable to standard criteria donation after brain death[J]. Am J Transplant, 2019, 19(2): 434-447. DOI: 10.1111/ajt.14991.
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