Application prospects of organoids in organ transplantation

Zhao Bing

doi:10.3969/j.issn.1674-7445.2022.02.004

Volume 13 Issue 2

Mar. 2022

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Zhao Bing. Application prospects of organoids in organ transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(2): 169-175. doi: 10.3969/j.issn.1674-7445.2022.02.004

Citation:

Zhao Bing. Application prospects of organoids in organ transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(2): 169-175. doi: 10.3969/j.issn.1674-7445.2022.02.004

Citation:

Zhao Bing. Application prospects of organoids in organ transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(2): 169-175. doi: 10.3969/j.issn.1674-7445.2022.02.004

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Application prospects of organoids in organ transplantation

doi: 10.3969/j.issn.1674-7445.2022.02.004

Zhao Bing^,

School of Life Sciences, Fudan University, Shanghai 200438, China

More Information

Corresponding author: Zhao Bing, Email: bingzhao@fudan.edu.cn
Received Date: 2021-11-27
Available Online: 2022-03-18
Publish Date: 2022-03-15

Abstract

Abstract

In recent years, organoid technology has become one of the major technological breakthroughs in biomedical field. As miniature organs constructed by three-dimensional culture of tissue stem cells in vitro, organoids are highly consistent with the source tissues in terms of tissue structures, cell types and functions, which serve as an ideal model for biomedical basic research, drug research and development and clinical precision medicine, and show important potential value in regenerative medicine. Organ transplantation is one of the most effective approaches to treat organ failure. However, the source of donor organs is currently limited, which could not meet the patients' needs. Identifying suitable graft substitutes is the key to breaking through the predicament. Organoids could be derived from the autologous tissues of patients. Multiple studies have demonstrated that organoids possess potent transplantation and repairing capabilities and may effectively avert the risk of immune rejection and tumorigenicity, etc. In this article, the development process and main application directions of organoid technology were summarized, and the application prospect and challenges of organoids in organ transplantation were reviewed and predicted.
- Organoid,
- Tissue stem cell,
- Organ transplantation,
- Regenerative medicine,
- Gene editing,
- Novel coronavirus,
- Cell therapy,
- 3D printing

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References(45)

References

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Application prospects of organoids in organ transplantation

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