Volume 12 Issue 5
Sep.  2021
Turn off MathJax
Article Contents
Article Navigation >  ORGAN TRANSPLANTATION  > 2021  >  12(5): 550-555
Ren Junkai, Zhang Tong. Application of dual hypothermic oxygenated machine perfusion in ex vivo split liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(5): 550-555. doi: 10.3969/j.issn.1674-7445.2021.05.008
Citation: Ren Junkai, Zhang Tong. Application of dual hypothermic oxygenated machine perfusion in ex vivo split liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(5): 550-555. doi: 10.3969/j.issn.1674-7445.2021.05.008
shu

Application of dual hypothermic oxygenated machine perfusion in ex vivo split liver transplantation

doi: 10.3969/j.issn.1674-7445.2021.05.008

  • Department of Hepatic Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China

More Information
  • Corresponding author: Zhang Tong, E-mail: zhjeff72@sina.com
  • Received Date: 2021-05-01
    Available Online: 2021-09-15
  • Publish Date: 2021-09-15
    Abstract
  • The technology of split liver transplantation is becoming increasingly mature with rapid development. During ex vivo splitting, the depletion of intracellular energy sources [such as adenosine triphosphate (ATP)] and other metabolic disorders may lead to cell damage and dysfunction, which will be aggravated by reperfusion injury of liver transplantation, clinically manifested as postoperative complications and transplantation failure. To further improve the quality of donor liver in ex vivo split liver transplantation, research teams at home and abroad apply machine perfusion to enhance the quality of donor liver. In this article, the research progresses worldwide on machine perfusion of donor liver in ex vivo split liver transplantation were reviewed, and the application and prospect of dual hypothermic oxygenated machine perfusion (D-HOPE) in ex vivo split liver transplantation were elucidated, aiming to provide reference for increasing the source of donor liver for ex vivo split liver transplantation and further resolving the current status of donorliver shortage.

     

    • FullText(HTML)
  • loading
    • References(32)
  • [1]
    REYES J, GERBER D, MAZARIEGOS GV, et al. Split-liver transplantation: a comparison of ex vivo and in situ techniques[J]. J Pediatr Surg, 2000, 35(2): 283-290. DOI: 10.1016/s0022-3468(00)90026-5.
    [2]
    CZIGANY Z, LURJE I, SCHMELZLE M, et al. Ischemia-reperfusion injury in marginal liver grafts and the role of hypothermic machine perfusion: molecular mechanisms and clinical implications[J]. J Clin Med, 2020, 9(3): 846. DOI: 10.3390/jcm9030846.
    [3]
    SPADA M, ANGELICO R, GRIMALDI C, et al. The new horizon of split-liver transplantation: ex situ liver splitting during hypothermic oxygenated machine perfusion[J]. Liver Transpl, 2020, 26(10): 1363-1367. DOI: 10.1002/lt.25843.
    [4]
    朱志军, 朱理玮, 淮明生, 等. 体外劈离式肝移植22例临床分析[J]. 中华器官移植杂志, 2010, 31(4): 199-202.

    ZHU ZJ, ZHU LW, HUAI MS, et al. A clinical report of 22 cases of ex vivo split-liver transplantation[J]. Chin J Organ Transplant, 2010, 31(4): 199-202.
    [5]
    SCHLEGEL A, MULLER X, DUTKOWSKI P. Hypothermic liver perfusion[J]. Curr Opin Organ Transplant, 2017, 22(6): 563-570. DOI: 10.1097/MOT.000 0000000000472.
    [6]
    NEMES B, GÁMÁN G, POLAK WG, et al. Extended criteria donors in liver transplantation part I: reviewing the impact of determining factors[J]. Expert Rev Gastroenterol Hepatol, 2016, 10(7): 827-839. DOI:10. 1586/17474124.2016.1149061.
    [7]
    WATSON CJE, JOCHMANS I. From "gut feeling" to objectivity: machine preservation of the liver as a tool to assess organ viability[J]. Curr Transplant Rep, 2018, 5(1): 72-81. DOI: 10.1007/s40472-018-0178-9.
    [8]
    MARCON F, SCHLEGEL A, BARTLETT DC, et al. Utilization of declined liver grafts yields comparable transplant outcomes and previous decline should not be a deterrent to graft use[J]. Transplantation, 2018, 102(5): e211-e218. DOI: 10.1097/TP.0000000000002127.
    [9]
    KARANGWA S, PANAYOTOVA G, DUTKOWSKI P, et al. Hypothermic machine perfusion in liver transplantation[J]. Int J Surg, 2020, 82S: 44-51. DOI: 10.1016/j.ijsu.2020.04.057.
    [10]
    欧阳青, 谭晓宇, 霍枫. 重视供肝机械灌注研究, 推动肝移植高质量发展[J]. 器官移植, 2021, 12(1): 1-7. DOI: 10.3969/j.issn.1674-7445.2021.01.001.

    OUYANG Q, TAN XY, HUO F. Attaching importance to mechanical perfusion of donor liver and promoting high-quality development of liver transplantation[J]. Organ Transplant, 2021, 12(1): 1-7. DOI: 10.3969/j.issn. 1674-7445.2021.01.001.
    [11]
    GROEN H, MOERS C, SMITS JM, et al. Cost-effectiveness of hypothermic machine preservation versus static cold storage in renal transplantation[J]. Am J Transplant, 2012, 12(7): 1824-1830. DOI: 10.1111/j.1600-6143.2012.04030.x.
    [12]
    KARANGWA SA, DUTKOWSKI P, FONTES P, et al. Machine perfusion of donor livers for transplantation: a proposal for standardized nomenclature and reporting guidelines[J]. Am J Transplant, 2016, 16(10): 2932-2942. DOI: 10.1111/ajt.13843.
    [13]
    KIM J, ZIMMERMAN MA, HONG JC. Emerging innovations in liver preservation and resuscitation[J]. Transplant Proc, 2018, 50(8): 2308-2316. DOI: 10.1016/j.transproceed.2018.03.080.
    [14]
    BESSEMS M, DOORSCHODT BM, KOLKERT JL, et al. Preservation of steatotic livers: a comparison between cold storage and machine perfusion preservation[J]. Liver Transpl, 2007, 13(4): 497-504. DOI: 10.1002/lt.21039.
    [15]
    GUARRERA JV, HENRY SD, SAMSTEIN B, et al. Hypothermic machine preservation in human liver transplantation: the first clinical series[J]. Am J Transplant, 2010, 10(2): 372-381. DOI: 10.1111/j.1600-6143.2009.02932.x.
    [16]
    DUTKOWSKI P, POLAK WG, MUIESAN P, et al. First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: an international-matched case analysis[J]. Ann Surg, 2015, 262(5): 764-771. DOI: 10.1097/SLA.0000000000001473.
    [17]
    VAN RIJN R, VAN LEEUWEN OB, MATTON APM, et al. Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers[J]. Liver Transpl, 2018, 24(5): 655-664. DOI: 10.1002/lt.25023.
    [18]
    VAN RIJN R, VAN DEN BERG AP, ERDMANN JI, et al. Study protocol for a multicenter randomized controlled trial to compare the efficacy of end-ischemic dual hypothermic oxygenated machine perfusion with static cold storage in preventing non-anastomotic biliary strictures after transplantation of liver grafts donated after circulatory death: DHOPE-DCD trial[J]. BMC Gastroenterol, 2019, 19(1): 40. DOI: 10.1186/s12876-019-0956-6.
    [19]
    VAN RIJN R, KARIMIAN N, MATTON APM, et al. Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death[J]. Br J Surg, 2017, 104(7): 907-917. DOI: 10.1002/bjs.10515.
    [20]
    THORNE AM, LANTINGA V, BODEWES S, et al. Ex situ dual hypothermic oxygenated machine perfusion for human split liver transplantation[J]. Transplant Direct, 2021, 7(3): e666. DOI: 10.1097/TXD.0000000000001116.
    [21]
    RAVIKUMAR R, LEUVENINK H, FRIEND PJ. Normothermic liver preservation: a new paradigm?[J]. Transpl Int, 2015, 28(6): 690-699. DOI: 10.1111/tri.12576.
    [22]
    VAN LEEUWEN OB, FUJIYOSHI M, UBBINK R, et al. Ex situ machine perfusion of human donor livers via the surgically reopened umbilical vein: a proof of concept[J]. Transplantation, 2019, 103(10): 2130-2135. DOI: 10.1097/TP.0000000000002615.
    [23]
    BROCKMANN JG, VOGEL T, COUSSIOS C, et al. Liver splitting during normothermic organ preservation[J]. Liver Transpl, 2017, 23(5): 701-706. DOI: 10.1002/lt.24693.
    [24]
    NASRALLA D, COUSSIOS CC, MERGENTAL H, et al. A randomized trial of normothermic preservation in liver transplantation[J]. Nature, 2018, 557(7703): 50-56. DOI: 10.1038/s41586-018-0047-9.
    [25]
    MERGENTAL H, PERERA MT, LAING RW, et al. Transplantation of declined liver allografts following normothermic ex-situ evaluation[J]. Am J Transplant, 2016, 16(11): 3235-3245. DOI: 10.1111/ajt.13875.
    [26]
    PATRONO D, CATALANO G, RIZZA G, et al. Perfusate analysis during dual hypothermic oxygenated machine perfusion of liver grafts: correlations with donor factors and early outcomes[J]. Transplantation, 2020, 104(9): 1929-1942. DOI: 10.1097/TP.0000000000003398.
    [27]
    中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组. 劈离式肝移植专家共识[J/CD]. 中华肝脏外科手术学电子杂志, 2020, 9(5): 429-434. DOI: 10.3877/cma.j.issn.2095-3232.2020.05.008.

    Operative Surgery Group of Branch of Surgery of Chinese Medical Association, Transplantation Group of Branch of Surgery of Chinese Medical Association. Expert consensus on split liver transplantation[J/CD]. Chin J Hepatic Surg (Electr Edit), 2020, 9(5): 429-434. DOI: 10.3877/cma.j.issn.2095-3232.2020.05.008.
    [28]
    NAGRATH D, XU H, TANIMURA Y, et al. Metabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo[J]. Metab Eng, 2009, 11(4/5): 274-283. DOI: 10.1016/j.ymben.2009.05.005.
    [29]
    BOTEON YL, ATTARD J, BOTEON APCS, et al. Manipulation of lipid metabolism during normothermic machine perfusion: effect of defatting therapies on donor liver functional recovery[J]. Liver Transpl, 2019, 25(7): 1007-1022. DOI: 10.1002/lt.25439.
    [30]
    KRON P, SCHLEGEL A, MANCINA L, et al. Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans[J]. J Hepatol, 2017: S0168-8278(17)32268-7. DOI: 10.1016/j.jhep.2017.08.028.
    [31]
    LAU NS, JACQUES A, MCCAUGHAN G, et al. Addressing the challenges of split liver transplantation through technical advances. a systematic review[J]. Transplant Rev (Orlando), 2021, 35(3): 100627. DOI: 10.1016/j.trre.2021.100627.
    [32]
    PERKINS JD, DICK AA, HEALEY PJ, et al. New evidence supporting increased use of split liver transplantation[J]. Transplantation, 2020, 104(2): 299-307. DOI: 10.1097/TP.0000000000002853.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(1)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (451) PDF downloads(74) Cited by()
    Proportional views
    Related

    WeChat Subscription Account

    Wechat Service Account

    Contact Us
    • Tel：020-38736410
    • Email: organtranspl@163.com
    • Address：The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou
    • Editorial Office of Organ Transplantation  粤ICP备2021030844号
    Links

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return