Volume 12 Issue 4
Jul.  2021
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Article Navigation >  ORGAN TRANSPLANTATION  > 2021  >  12(4): 484-488
He Yu, Ou Zhiyu, Miao Yun. The latest progress on JC virus infection after renal transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 484-488. doi: 10.3969/j.issn.1674-7445.2021.04.017
Citation: He Yu, Ou Zhiyu, Miao Yun. The latest progress on JC virus infection after renal transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 484-488. doi: 10.3969/j.issn.1674-7445.2021.04.017
shu

The latest progress on JC virus infection after renal transplantation

doi: 10.3969/j.issn.1674-7445.2021.04.017

  • Department of Organ Transplantation, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China

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  • Corresponding author: Miao Yun, Email: miaoyunecho@126.com
  • Received Date: 2021-04-19
    Available Online: 2021-07-13
  • Publish Date: 2021-07-15
    Abstract
  • JC virus (JCV) is a member of polyomaviridae family that infects approximately 70% of the population worldwide. JCV constantly stays in a latent state after the primary infection. In immunosuppressed individuals, especially under the circumstances of low cellular immune function, JCV may be reactivated and lead to severe clinical manifestations. In recent years, the correlation between JCV and complications after renal transplantation has captivated widespread attention. JCV-associated nephropathy (JCVAN) has been reported. Here, latest research progresses on the epidemiology, molecular biology, in vivo infection process, JCV and complications after renal transplantation, and the relationship between JCV and BKV were reviewed, aiming to provide reference for the adjustment of immunosuppressive regimen following renal transplantation.

     

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