Early outcomes of heart transplantation in critical patients: single center experience of Fuwai Hospital

Zheng Shanshan; Liu Sheng; Tang Hanwei; Song Yunhu; Wang wei; Huang Jie; Liao Zhongkai; Zheng Zhe

doi:10.3969/j.issn.1674-7445.2021.04.012

Volume 12 Issue 4

Jul. 2021

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Zheng Shanshan, Liu Sheng, Tang Hanwei, et al. Early outcomes of heart transplantation in critical patients: single center experience of Fuwai Hospital[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 450-457. doi: 10.3969/j.issn.1674-7445.2021.04.012

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Early outcomes of heart transplantation in critical patients: single center experience of Fuwai Hospital

doi: 10.3969/j.issn.1674-7445.2021.04.012

Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China

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Corresponding author: Zheng Zhe, Email: zhengzhe@fuwai.com
Received Date: 2021-04-08
Available Online: 2021-07-13
Publish Date: 2021-07-15

Abstract

Abstract

Objective To analyze the early outcomes of heart transplantation in critical patients and its significance in donor allocation decision. Methods Clinical data of 449 recipients undergoing heart transplantation were retrospectively analyzed. According to preoperative status, all patients were divided into the critical status group (n=64) and general status group (n=385). The incidence of critical status was summarized. Clinical data of recipients were statistically compared between two groups. Postoperative survival and causes of death in recipients between two groups were analyzed. Perioperative results of critical recipients undergoing different mechanical circulation support as a bridge to heart transplantation were compared. Results Critical patients accounted for 14.3% of the total number of transplant recipients. The proportion of critical patients gradually increased in recent 5 years. Compared with the general status group, the recipients in critical status group had a lower proportion of smoking history, a higher proportion of cardiac surgery history, a higher serum level of creatinine, and a higher proportion of primary diseases of heart failure before heart transplantation(all P≤0.01). The proportion of undergoing mechanical circulation support was higher, the incidence of complications was higher, the stay time in intensive care unit (ICU) was longer and the in-hospital fatality was higher after heart transplantation in the critical status group (all P≤0.01). The 1-year survival rate of recipients in critical status group was significantly lower than that in general status group (83% vs. 95%, P < 0.01). The fatality of recipients due to infection and multiple organ failure in critical status group was higher than that in general status group. Among 64 critical recipients, 1 recipient received ventilator alone, and 63 recipients underwent mechanical circulation support devices as a bridge to heart transplantation. Among them, intra-aortic balloon pump (IABP) alone was applied in 49 cases (77%), 8 cases (13%) of extracorporeal membrane oxygenation (ECMO) combined with IABP, 4 cases (6%) of ECMO alone, and 2 cases (3%) of left ventricular assist device (LVAD) alone. Critical patients who received preoperative ECMO and ECMO combined with IABP bridging to heart transplantation have a higher proportion of postoperative complications, a longer ICU stay time, a longer mechanical ventilation time, and a higher proportion of hospital deaths. Conclusions The overall prognosis of critical patients undergoing heart transplantation is relatively poor. Effective preoperative management may reverse the high-risk status of critical patients in a certain extent. The limited quantity of donor heart should be allocated to the most urgent patients who can obtain the greatest benefit from heart transplantation.
- Heart transplantation,
- Critical status,
- General status,
- Intra-aortic balloon pump (IABP),
- Extracorporeal membrane oxygenation (ECMO),
- Left ventricular assist device (LVAD),
- Donor allocation,
- Cardiac failure

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References

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Early outcomes of heart transplantation in critical patients: single center experience of Fuwai Hospital

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