Volume 12 Issue 4
Jul.  2021
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Article Navigation >  ORGAN TRANSPLANTATION  > 2021  >  12(4): 445-449
Liu Zhaobo, Wu Jushan, Lin Dongdong, et al. Safety of PD-1 inhibitor in preoperative treatment of liver transplantation for liver cancer[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 445-449. doi: 10.3969/j.issn.1674-7445.2021.04.011
Citation: Liu Zhaobo, Wu Jushan, Lin Dongdong, et al. Safety of PD-1 inhibitor in preoperative treatment of liver transplantation for liver cancer[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 445-449. doi: 10.3969/j.issn.1674-7445.2021.04.011
shu

Safety of PD-1 inhibitor in preoperative treatment of liver transplantation for liver cancer

doi: 10.3969/j.issn.1674-7445.2021.04.011

  • General Surgery Center, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China

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    Abstract
  •   Objective  To evaluate the safety of programmed cell death protein 1 (PD-1) inhibitor in the treatment of primary liver cancer (liver cancer) before liver transplantation.  Methods  Clinical data of 7 recipients given with PD-1 inhibitor before liver transplantation for liver cancer were retrospectively analyzed. The incidence of immune-related adverse event (irAE) and clinical prognosis of the recipients were summarized. The safety of PD-1 inhibitor in recipients prior to liver transplantation for liver cancer was evaluated.  Results  Seven recipients were treated with PD-1 inhibitor with 1-20 courses before liver transplantation for liver cancer. The time interval from drug withdrawal to liver transplantation was 6-120 d. Five recipients suffered from irAE of different degrees, including fatigue in 3 cases, fever in 2 cases, alopecia in 2 cases, rash in 1 case, nausea in 1 case and myocarditis in 1 case, respectively. A majority of these irAE were classified as grade Ⅰ-Ⅱ. One recipient died from grade Ⅴ irAE (fatal myocarditis). One recipient developed rejection at postoperative 7 d, which were mitigated after glucocorticoid pulse therapy combined with increased dosage of tacrolimus.  Conclusions  PD-1 inhibitor can be applied in preoperative treatment before liver transplantation for liver cancer. Nevertheless, the incidence of irAE and postoperative rejection should be intimately monitored.

     

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