Research status and prospect of basic application of islet organoid

Wu Lingling; Jiang Peng; Wu Zhen; Li Wanli; Yang Yuwei; Gao Hongjun

doi:10.3969/j.issn.1674-7445.2021.04.005

Volume 12 Issue 4

Jul. 2021

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Wu Lingling, Jiang Peng, Wu Zhen, et al. Research status and prospect of basic application of islet organoid[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 397-402. doi: 10.3969/j.issn.1674-7445.2021.04.005

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Wu Lingling, Jiang Peng, Wu Zhen, et al. Research status and prospect of basic application of islet organoid[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 397-402. doi: 10.3969/j.issn.1674-7445.2021.04.005

Citation:

Wu Lingling, Jiang Peng, Wu Zhen, et al. Research status and prospect of basic application of islet organoid[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 397-402. doi: 10.3969/j.issn.1674-7445.2021.04.005

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Research status and prospect of basic application of islet organoid

doi: 10.3969/j.issn.1674-7445.2021.04.005

Guangxi University of Chinese Medicine, Nanning 530011, China

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Corresponding author: Gao Hongjun, Email: gao4056@163.com
Received Date: 2021-03-01
Available Online: 2021-07-13
Publish Date: 2021-07-15

Abstract

Abstract

Organoids are tissue structures, generated from pluripotent stem cells and cultured in vitro, which form self-organize and recapitulate tissues with similar structure and function to the original organs. Organoids have similar appearance and function to the original tissues, and have been widely applied in basic research and clinical trial. At present, the organoids of liver, kidney, islet, brain, intestine and other organs have been successfully cultivated. The use of islet organoid is a hotspot in the field of organoid research. However, islet organoid is currently applied in basic research because rejection after organ transplantation and other issues remain unresolved. In this article, the origin, development and basic application of islet organoid were reviewed, aiming to provide reference for the transformation from basic research of islet organoid into clinical application as well as the treatment of diabetes mellitus.

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References

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Research status and prospect of basic application of islet organoid

doi: 10.3969/j.issn.1674-7445.2021.04.005

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Research status and prospect of basic application of islet organoid

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