Volume 11 Issue 6
Jan.  2021
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Dong Yan, Zhao Hong, Man Jiangwei, et al. Expression and role of matrix metalloproteinase in injury related renal transplantation[J]. ORGAN TRANSPLANTATION, 2020, 11(6): 760-764. doi: 10.3969/j.issn.1674-7445.2020.06.018
Citation: Dong Yan, Zhao Hong, Man Jiangwei, et al. Expression and role of matrix metalloproteinase in injury related renal transplantation[J]. ORGAN TRANSPLANTATION, 2020, 11(6): 760-764. doi: 10.3969/j.issn.1674-7445.2020.06.018

Expression and role of matrix metalloproteinase in injury related renal transplantation

doi: 10.3969/j.issn.1674-7445.2020.06.018
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  • Corresponding author: Yang Li, E-mail:yuze250@126.com
  • Received Date: 2020-07-27
    Available Online: 2021-01-19
  • Publish Date: 2021-01-19
  • Matrix metalloproteinase (MMP) is a large class of proteases which can cut or reshape extracellular matrix (ECM) and cell surface proteins. The activity of MMP is regulated by a variety of cytokines, including tissue inhibitor of metalloprotease (TIMP), signal transduction molecules and cell adhesion molecules. The latest research shows that MMP has a role in the pathophysiology process of many acute and chronic kidney diseases. In this article, the classification, expression and distribution in the kidney of MMP and its role in injury related renal transplantation was reviewed.

     

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