Research progress on dendritic cell in immune tolerance of organ transplantation

Xu Junming; Zhou Lin; He Qiang

doi:10.3969/j.issn.1674-7445.2020.05.017

Volume 11 Issue 5

Sep. 2020

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Xu Junming, Zhou Lin, He Qiang. Research progress on dendritic cell in immune tolerance of organ transplantation[J]. ORGAN TRANSPLANTATION, 2020, 11(5): 629-634. doi: 10.3969/j.issn.1674-7445.2020.05.017

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Research progress on dendritic cell in immune tolerance of organ transplantation

doi: 10.3969/j.issn.1674-7445.2020.05.017

Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

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Corresponding author: He Qiang, Email:heqiang349@sina.com
Received Date: 2020-05-21
Available Online: 2021-01-19
Publish Date: 2020-09-15

Abstract

Abstract

Dendritic cell (DC) is professional antigen presenting cell with specific functions. DC can specifically phagocytize antigen, and process and deliver to effector T cell, which play an important role in immune tolerance and immune response. Tolerance DC (tol-DC) is a group of DC with negative immune regulatory function, which can induce immune tolerance of organ transplantation through central and peripheral mechanism. In this article, the phenotype and functional characteristics of DC, mechanism of immune tolerance induced by DC, and the application of tol-DC in organ transplantation of DC were summarized, aiming to provide basic theoretical support for clinical translational medicine research.
- Dendritic cell,
- Organ transplantation,
- Immune tolerance,
- Immune response,
- Immune regulation,
- Immunosuppressant,
- Cytokine,
- Genetic engineering

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References(40)

References

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Research progress on dendritic cell in immune tolerance of organ transplantation

doi: 10.3969/j.issn.1674-7445.2020.05.017

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