Volume 11 Issue 3
May  2020
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Miao Xiaolei, Wu Yan, Wu Anshi. Research progress of nervous system and neurocognition-related complications after liver transplantation[J]. ORGAN TRANSPLANTATION, 2020, 11(3): 424-430. doi: 10.3969/j.issn.1674-7445.2020.03.018
Citation: Miao Xiaolei, Wu Yan, Wu Anshi. Research progress of nervous system and neurocognition-related complications after liver transplantation[J]. ORGAN TRANSPLANTATION, 2020, 11(3): 424-430. doi: 10.3969/j.issn.1674-7445.2020.03.018

Research progress of nervous system and neurocognition-related complications after liver transplantation

doi: 10.3969/j.issn.1674-7445.2020.03.018
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  • Corresponding author: Wu Yan, E-mail:wuyan@bjcyh.com; Wu Anshi, E-mail:wuanshi88@163.com
  • Received Date: 2020-02-02
    Available Online: 2021-01-19
  • Publish Date: 2020-05-15
  • The postoperative nervous system and neurocognition-related complications have become an important issue of research focus with the gradual increase of the survival rate after liver transplantation. Compared to other solid organ transplantation, the incidence of nervous system complications after liver transplantation is higher and closely related to death. This paper mainly overviewed the nervous system complications, neurocognition-related complications after liver transplantation and the risk factors inducing these complications. It also discussed how to evaluate, monitor, and prevent these complications in order to provide reference for future studies.

     

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  • [1]
    FELTRACCO P, CAGNIN A, CAROLLO C, et al. Neurological disorders in liver transplant candidates: pathophysiology and clinical assessment[J]. Transplant Rev (Orlando), 2017, 31(3): 193-206. DOI: 10.1016/j.trre.2017.02.006.
    [2]
    CHUNG MS, KIM HS, LIM YS, et al. Clinical impact of preoperative brain MR angiography and MR imaging in candidates for liver transplantation: a propensity score-matching study in a single institution[J]. Eur Radiol, 2017, 27(8): 3532-3541. DOI: 10.1007/s00330-017-4741-z.
    [3]
    MAGGI DC, BORGONOVO A, BANSHO ET, et al. Serial assessment of hepatic encephalopathy in patients hospitalised for acute decompensation of cirrhosis[J]. Ann Hepatol, 2019, 18(2): 331-337. DOI: 10.1016/j.aohep.2018.11.002.
    [4]
    ROMERO- GÓMEZ M, MONTAGNESE S, JALAN R. Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure[J]. J Hepatol, 2015, 62(2): 437-447. DOI: 10.1016/j.jhep.2014.09.005.
    [5]
    BJERRING PN, BJERRUM EJ, LARSEN FS. Impaired cerebral microcirculation induced by ammonium chloride in rats is due to cortical adenosine release[J]. J Hepatol, 2018, 68(6): 1137-1143. DOI: 10.1016/j.jhep.2018.01.034.
    [6]
    DERLE E, KIBAROǦL US, ÖCAL R, et al. Seizure as a neurologic complication after liver transplant[J]. Exp Clin Transplant, 2015, 13 (Suppl 1): 323-326. DOI: 10.6002/ect.mesot2014.p176.
    [7]
    CHOI EJ, KANG JK, LEE SA, et al. New-onset seizures after liver transplantation: clinical implications and prognosis in survivors[J]. Eur Neurol, 2004, 52(4): 230-236. DOI: 10.1159/000082163.
    [8]
    AMODIO P, BIANCARDI A, MONTAGNESE S, et al. Neurological complications after orthotopic liver transplantation[J]. Dig Liver Dis, 2007, 39(8): 740-747. DOI: 10.1016/j.dld.2007.05.004.
    [9]
    WSZOLEK ZK, STEG RE. Seizures after orthotopic liver transplantation[J]. Seizure, 1997, 6(1): 31-39. DOI: 10.1016/s1059-1311(97)80050-7.
    [10]
    LECKER I, WANG DS, KANESHWARAN K, et al. High concentrations of tranexamic acid inhibit ionotropic glutamate receptors[J]. Anesthesiology, 2017, 127(1): 89-97. DOI: 10.1097/ALN.0000000000001665.
    [11]
    CRISMALE JF, MELIAMBRO KA, DEMARIA S JR, et al. Prevention of the osmotic demyelination syndrome after liver transplantation: a multidisciplinary perspective[J]. Am J Transplant, 2017, 17(10): 2537-2545. DOI: 10.1111/ajt.14317.
    [12]
    SINGH TD, FUGATE JE, RABINSTEIN AA. Central pontine and extrapontine myelinolysis: a systematic review[J]. Eur J Neurol, 2014, 21(12): 1443-1450. DOI: 10.1111/ene.12571.
    [13]
    MORARD I, GASCHE Y, KNETEMAN M, et al. Identifying risk factors for central pontine and extrapontine myelinolysis after liver transplantation: a case-control study[J]. Neurocrit Care, 2014, 20(2): 287-295. DOI: 10.1007/s12028-013-9928-9.
    [14]
    HOORN EJ, ZIETSE R. Diagnosis and treatment of hyponatremia: compilation of the guidelines[J]. J Am Soc Nephrol, 2017, 28(5): 1340-1349. DOI: 10.1681/ASN.2016101139.
    [15]
    SHARMA P, SCHAUBEL DE, GOODRICH NP, et al. Serum sodium and survival benefit of liver transplantation[J]. Liver Transpl, 2015, 21(3): 308-313. DOI: 10.1002/lt.24063.
    [16]
    DONNELLY H, CONNOR S, QUIRK J. Central pontine myelinolysis secondary to hyperglycaemia[J]. Pract Neurol, 2016, 16(6): 493-495. DOI: 10.1136/practneurol-2016-001389.
    [17]
    LOUIS G, MEGARBANE B, LAVOUÉ S, et al. Long-term outcome of patients hospitalized in intensive care units with central or extrapontine myelinolysis*[J]. Crit Care Med, 2012, 40(3): 970-972. DOI: 10.1097/CCM.0b013e318236f152.
    [18]
    FUGATE JE, RABINSTEIN AA. Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions[J]. Lancet Neurol, 2015, 14(9): 914-925. DOI: 10.1016/S1474-4422(15)00111-8.
    [19]
    BERNHARDT M, PFLUGRAD H, GOLDBECKER A, et al. Central nervous system complications after liver transplantation: common but mostly transient phenomena[J]. Liver Transpl, 2015, 21(2): 224-232. DOI: 10.1002/lt.24035.
    [20]
    CRUZ RJ JR, DIMARTINI A, AKHAVANHEIDARI M, et al. Posterior reversible encephalopathy syndrome in liver transplant patients: clinical presentation, risk factors and initial management[J]. Am J Transplant, 2012, 12(8): 2228-2236. DOI: 10.1111/j.1600-6143.2012.04048.x.
    [21]
    BARTYNSKI WS. Posterior reversible encephalopathy syndrome, part 1: fundamental imaging and clinical features[J]. AJNR Am J Neuroradiol, 2008, 29(6): 1036-1042. DOI: 10.3174/ajnr.A0928.
    [22]
    BARTYNSKI WS. Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema[J]. AJNR Am J Neuroradiol, 2008, 29(6): 1043-1049. DOI: 10.3174/ajnr.A0929.
    [23]
    OLLIVIER M, BERTRAND A, CLARENÇON F, et al. Neuroimaging features in posterior reversible encephalopathy syndrome: a pictorial review[J]. J Neurol Sci, 2017, 373: 188-200. DOI: 10.1016/j.jns.2016.12.007.
    [24]
    PEDERSEN M, SEETHARAM A. Infections after orthotopic liver transplantation[J]. J Clin Exp Hepatol, 2014, 4(4): 347-360. DOI: 10.1016/j.jceh.2014.07.004.
    [25]
    PHAN TL, LAUTENSCHLAGER I, RAZONABLE RR, et al. HHV-6 in liver transplantation: a literature review[J]. Liver Int, 2018, 38(2): 210-223. DOI: 10.1111/liv.13506.
    [26]
    CHARLIER C, PERRODEAU É, LECLERCQ A, et al. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study[J]. Lancet Infect Dis, 2017, 17(5): 510-519. DOI: 10.1016/S1473-3099(16)30521-7.
    [27]
    DALTON HR, VAN EIJK JJJ, CINTAS P, et al. Hepatitis E virus infection and acute non-traumatic neurological injury: a prospective multicentre study[J]. J Hepatol, 2017, 67(5): 925-932. DOI: 10.1016/j.jhep.2017.07.010.
    [28]
    JOLLEY SE, BUNNELL AE, HOUGH CL. ICU-acquired weakness[J]. Chest, 2016, 150(5): 1129-1140. DOI: 10.1016/j.chest.2016.03.045.
    [29]
    GREENHILL C. Liver transplantation: long-term cognitive function improved in MHE after liver transplantation[J]. Nat Rev Gastroenterol Hepatol, 2012, 9(3): 126. DOI: 10.1038/nrgastro.2012.17.
    [30]
    CAMPAGNA F, MONTAGNESE S, SCHIFF S, et al. Cognitive impairment and electroencephalographic alterations before and after liver transplantation: what is reversible? [J]. Liver Transpl, 2014, 20(8): 977-986. DOI: 10.1002/lt.23909.
    [31]
    FINEBERG SK, WEST A, NA PJ, et al. Utility of pretransplant psychological measures to predict posttransplant outcomes in liver transplant patients: a systematic review[J]. Gen Hosp Psychiatry, 2016, 40: 4-11. DOI: 10.1016/j.genhosppsych.2016.01.006.
    [32]
    ACETO P, PERILLI V, LAI C, et al. Postoperative cognitive dysfunction after liver transplantation[J]. Gen Hosp Psychiatry, 2015, 37(2): 109-115. DOI: 10.1016/j.genhosppsych.2014.12.001.
    [33]
    PFLUGRAD H, TRYC AB, GOLDBECKER A, et al. Hepatic encephalopathy before and neurological complications after liver transplantation have no impact on the employment status 1 year after transplantation[J]. World J Hepatol, 2017, 9(10): 519-532. DOI: 10.4254/wjh.v9.i10.519.
    [34]
    PEGUM N, CONNOR JP, FEENEY GF, et al. Neuropsychological functioning in patients with alcohol-related liver disease before and after liver transplantation[J]. Transplantation, 2011, 92(12): 1371-1377. DOI: 10.1097/TP.0b013e3182375881.
    [35]
    SENZOLO M, PIZZOLATO G, FERRONATO C, et al. Long-term evaluation of cognitive function and cerebral metabolism in liver transplanted patients[J]. Transplant Proc, 2009, 41(4): 1295-1296. DOI: 10.1016/j.transproceed.2009.03.087.
    [36]
    CHAVARRIA L, ALONSO J, GARCÍA-MARTÍNEZ R, et al. Biexponential analysis of diffusion-tensor imaging of the brain in patients with cirrhosis before and after liver transplantation[J]. AJNR Am J Neuroradiol, 2011, 32(8): 1510-1517. DOI: 10.3174/ajnr.A2533.
    [37]
    ISHIHARA T, ITO M, NIIMI Y, et al. Clinical and radiological impact of liver transplantation for brain in cirrhosis patients without hepatic encephalopathy[J]. Clin Neurol Neurosurg, 2013, 115(11): 2341-2347. DOI: 10.1016/j.clineuro.2013.08.015.
    [38]
    LIN WC, CHOU KH, CHEN CL, et al. Longitudinal brain white matter alterations in minimal hepatic encephalopathy before and after liver transplantation[J]. PLoS One, 2014, 9(8): e105887. DOI: 10.1371/journal.pone.0105887.
    [39]
    CHENG Y, HUANG L, ZHANG X, et al. Liver transplantation nearly normalizes brain spontaneous activity and cognitive function at 1 month: a resting-state functional MRI study[J]. Metab Brain Dis, 2015, 30(4): 979-988. DOI: 10.1007/s11011-015-9657-1.
    [40]
    ZHANG XD, CHENG Y, POON CS, et al. Long-and short-range functional connectivity density alteration in non-alcoholic cirrhotic patients one month after liver transplantation: a resting-state fMRI study[J]. Brain Res, 2015, 1620: 177-187. DOI: 10.1016/j.brainres.2015.04.046.
    [41]
    CHENG Y, HUANG LX, ZHANG L, et al. Longitudinal intrinsic brain activity changes in cirrhotic patients before and one month after liver transplantation[J]. Korean J Radiol, 2017, 18(2): 370-377. DOI: 10.3348/kjr.2017.18.2.370.
    [42]
    CHENG Y, ZHANG G, SHEN W, et al. Impact of previous episodes of hepatic encephalopathy on short-term brain function recovery after liver transplantation: a functional connectivity strength study[J]. Metab Brain Dis, 2018, 33(1): 237-249. DOI: 10.1007/s11011-017-0155-5.
    [43]
    FU KA, DINORCIA J, SHER L, et al. Predictive factors of neurological complications and one-month mortality after liver transplantation[J]. Front Neurol, 2014, 5: 275. DOI: 10.3389/fneur.2014.00275.
    [44]
    WU SY, CHEN TW, FENG AC, et al. Comprehensive risk assessment for early neurologic complications after liver transplantation[J]. World J Gastroenterol, 2016, 22(24): 5548-5557. DOI: 10.3748/wjg.v22.i24.5548.
    [45]
    WEISS N, JALAN R, THABUT D. Understanding hepatic encephalopathy[J]. Intensive Care Med, 2018, 44(2): 231-234. DOI: 10.1007/s00134-017-4845-6.
    [46]
    YOU DD, CHOI GS, KIM JM, et al. Long-term outcomes for liver transplant recipients in terms of hepatic encephalopathy[J]. Transplant Proc, 2017, 49(6): 1425-1429. DOI: 10.1016/j.transproceed.2017.02.054.
    [47]
    ALLAMPATI S, MULLEN KD. Does overt hepatic encephalopathy cause persistent cognitive defects even after successful liver transplantation? [J]. Liver Transpl, 2014, 20(8): 874-875. DOI: 10.1002/lt.23938.
    [48]
    WEISS N, MOCHEL F, RUDLER M, et al. Peak hyperammonemia and atypical acute liver failure: the eruption of an urea cycle disorder during hyperemesis gravidarum[J]. J Hepatol, 2018, 68(1): 185-192. DOI: 10.1016/j.jhep.2017.09.009.
    [49]
    WEINSTEIN G, ZELBER-SAGI S, PREIS SR, et al. Association of nonalcoholic fatty liver disease with lower brain volume in healthy middle-aged adults in the framingham study[J]. JAMA Neurol, 2018, 75(1): 97-104. DOI: 10.1001/jamaneurol.2017.3229.
    [50]
    AHLUWALIA V, WADE JB, MOELLER FG, et al. The etiology of cirrhosis is a strong determinant of brain reserve: a multimodal magnetic resonance imaging study[J]. Liver Transpl, 2015, 21(9): 1123-1132. DOI: 10.1002/lt.24163.
    [51]
    WU WY, KANG KH, CHEN SL, et al. Hepatitis C virus infection: a risk factor for Parkinson's disease[J]. J Viral Hepat, 2015, 22(10): 784-791. DOI: 10.1111/jvh.12392.
    [52]
    SAKUSIC A, O'HORO JC, DZIADZKO M, et al. Potentially modifiable risk factors for long-term cognitive impairment after critical illness: a systematic review[J]. Mayo Clin Proc, 2018, 93(1): 68-82. DOI: 10.1016/j.mayocp.2017.11.005.
    [53]
    MONK TG, WELDON BC, GARVAN CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery[J]. Anesthesiology, 2008, 108(1): 18-30. DOI: 10.1097/01.anes.0000296071.19434.1e.
    [54]
    MERLI M, LUCIDI C, PENTASSUGLIO I, et al. Increased risk of cognitive impairment in cirrhotic patients with bacterial infections[J]. J Hepatol, 2013, 59(2): 243-250. DOI: 10.1016/j.jhep.2013.03.012.
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