Volume 11 Issue 2
Mar.  2020
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Pan Tianzhong, Tang Baolin, Zhu Xiaoyu, et al. Effect of pretransplant iron overload on clinical efficacy of allogeneic hematopoietic stem cell transplantation on severe aplastic anemia[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 234-239. doi: 10.3969/j.issn.1674-7445.2020.02.008
Citation: Pan Tianzhong, Tang Baolin, Zhu Xiaoyu, et al. Effect of pretransplant iron overload on clinical efficacy of allogeneic hematopoietic stem cell transplantation on severe aplastic anemia[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 234-239. doi: 10.3969/j.issn.1674-7445.2020.02.008
shu

Effect of pretransplant iron overload on clinical efficacy of allogeneic hematopoietic stem cell transplantation on severe aplastic anemia

doi: 10.3969/j.issn.1674-7445.2020.02.008

  • Anhui Medical University, Heifei 230000, China

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  • Corresponding author: Sun Zimin, Email: zmsun_vip@163.com
  • Received Date: 2019-12-17
    Available Online: 2021-01-19
  • Publish Date: 2020-03-15
    Abstract
  •   Objective  To evaluate the effect of pretransplant iron overload on the clinical efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with severe aplastic anemia (SAA).  Methods  Clinical data of 80 SAA recipients who underwent allo-HSCT for the first time were retrospectively analyzed. According to the incidence of iron overload, all recipients were divided into the iron overload group (n=20) and non-iron overload group (n=60). The engraftment rate, incidence of postoperative complications and clinical prognosis of the recipients afterallo-HSCT were statistically compared between two groups. The influencing factors of 2-year overall survival (OS) and 180 d transplantation related mortality (TRM) were analyzed by Cox proportional hazards regression model.  Results  The engraftment rate of neutrophils in the non-iron overload group was 98% (59/60), significantly higher than 75% (15/20) in the iron overload group (P < 0.05). The engraftment rate of platelet in the non-iron overload group was 90% (54/60), significantly higher than 65% (13/20) in the iron overload group (P < 0.05). The incidence rate of bloodstream infection in the non-iron overload group was 23% (14/60), remarkably lower than 40% (8/20) in the iron overload group (P < 0.05). The 180 d TRM of the recipients in the non-iron overload group was 17%, significantly lower than 45% in the iron overload group (P < 0.05). The 1- and 2-year OS of the recipients in the non-iron overload group were 82% and 80%, significantly higher than 50% and 44% in the iron overload group (both P < 0.05). Iron overload or not was an independent risk factor of the OS and TRM of the recipients (both P < 0.05).  Conclusions  Iron overload can affect the OS and TRM of SAA patients after allo-HSCT.

     

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