Volume 9 Issue 6
Nov.  2018
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Article Navigation >  ORGAN TRANSPLANTATION  > 2018  >  9(6): 430-435, 477
Pan Xiaoming, Xue Wujun, Tian Puxun, et al. Application of LifePort organ transporter to improve clinical efficacy of renal transplantation: a report of 573 cases[J]. ORGAN TRANSPLANTATION, 2018, 9(6): 430-435, 477. doi: 10.3969/j.issn.1674-7445.2018.06.006
Citation: Pan Xiaoming, Xue Wujun, Tian Puxun, et al. Application of LifePort organ transporter to improve clinical efficacy of renal transplantation: a report of 573 cases[J]. ORGAN TRANSPLANTATION, 2018, 9(6): 430-435, 477. doi: 10.3969/j.issn.1674-7445.2018.06.006
shu

Application of LifePort organ transporter to improve clinical efficacy of renal transplantation: a report of 573 cases

doi: 10.3969/j.issn.1674-7445.2018.06.006

  • Center of Nephropathy, the First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710061, China

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  • Corresponding author: Pan Xiaoming, Email:drpanxiaoming@126.com
  • Received Date: 2018-08-19
    Available Online: 2021-01-19
  • Publish Date: 2018-11-15
    Abstract
  •   Objective  To evaluate the effect of the preservation of the donor kidneys from donation after cardiac death (DCD) and expanded criteria donor (ECD) by donor kidney pulse perfusion storage transporter (LifePort) on the postoperative recovery of renal function in recipients undergoing renal transplantation.  Methods  Perioperative clinical data of 466 donors (DCD+ECD) and 882 recipients undergoing renal transplantation were retrospectively analyzed. According to different approaches of kidney preservation, bilateral kidneys of 309 DCD donors were randomly divided into the LifePort group(DCD-LP, n=309) and DCD cold storage group (n=309). All the bilateral kidneys of 132 ECD donors were stored and transported by LifePort and assigned into the ECD-LP group (n=264). The postoperative overall condition, early postoperative renal function indexes and postoperative complications of the recipients were observed among three groups. The pathological findings of renal puncture before renal transplantation were observed in donor kidneys. The LifePort perfusion parameters of the donor kidney were compared between the recipients with and without delayed graft function (DGF) after renal transplantation.  Results  Compared with the DCD cold storage group, the length of hospital stay was significantly shorter in the DCD-LP and ECD-LP groups (both P < 0.05). The survival rate of the recipients was 100% in three groups. The survival rate of the donor kidney was 99.7%, 100% and 99.2% in the DCD cold storage, DCD-LP and ECD-LP groups, respectively. No statistical difference was observed among three groups (all P > 0.05). Compared with the DCD cold storage group, the incidence of DGF was significantly lower in the DCD-LP and ECD-LP groups (both P < 0.05). Early postoperative renal function, the incidence of acute rejection, infection and surgical complications did not significantly differ among three groups (all P > 0.05). Pathological examination demonstrated that usage of LifePort perfusion could significantly mitigate the edema, degeneration and necrosis of renal tubules. In the recipients with DGF, the LifePort perfusion resistance index of donor kidney was significantly higher, whereas the LifePort perfusion volume of donor kidney was considerably lower than those without DGF (both P < 0.05).  Conclusions  LifePort can effectively improve the quality of the donor kidney from DCD and ECD in vitro, reduce the incidence of postoperative DGF, promote the recovery of transplanted kidney function and predict the postoperative recovery during the maintenance and evaluation of the isolated kidney.

     

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    • References(19)
  • [1]
    LEVY M. State incentives to promote organ donation: honoring the principles of reciprocity and solidarity inherent in the gift relationship[J]. J Law Biosci, 2018, 5(2): 398-435. DOI: 10.1093/jlb/lsy009.
    [2]
    CHATTERJEE P, VENKATARAMANI AS, VIJAYAN A, et al. The effect of state policies on organ donation and transplantation in the United States[J]. JAMA Intern Med, 2015, 175(8): 1323-1329. DOI: 10.1001/jamainternmed.2015.2194.
    [3]
    范鹏飞, 张玮晔.心脏死亡器官捐献供肝功能维护的研究进展[J/CD].实用器官移植电子杂志, 2016, 4(5): 311-314. DOI: 10.3969/j.issn.2095-5332.2016.05.012.

    FAN PF, ZHANG WY. Research Progress on donor liver function maintenance of donation after cardiac death[J/CD]. Pract J Organ Transplant (Electr Vers), 2016, 4(5): 311-314. DOI: 10.3969/j.issn.2095-5332.2016.05.012.
    [4]
    中华医学会器官移植学分会.中国心脏死亡器官捐献工作指南(第2版)[J].中华器官移植杂志, 2011, 32(12): 756-758. DOI: 10.3760/cma.j.issn.0254-1785.2011.12.014.

    Branch of Organ Transplantation of Chinese Medical Association. Work guideline of donation after cardiac death in China(2nd edition)[J]. Chin J Organ Transplant, 2011, 32(12): 756-758. DOI: 10.3760/cma.j.issn.0254-1785.2011.12.014.
    [5]
    FARNEY AC, SINGH RP, HINES MH, et al. Experience in renal and extrarenal transplantation with donation after cardiac death donors with selective use of extracorporeal support[J]. J Am Coll Surg, 2008, 206(5): 1028-1037. DOI: 10.1016/j.jamcollsurg.2007.12.029.
    [6]
    PINE JK, GOLDSMITH PJ, RIDGWAY DM, et al. Comparable outcomes in donation after cardiac death and donation after brainstem death: a matched analysis of renal transplants[J]. Transplant Proc, 2010, 42(10): 3947-3948. DOI: 10.1016/j.transproceed.2010.09.072.
    [7]
    MONBALIU D, PIRENNE J, TALBOT D. Liver transplantation using donation after cardiac death donors[J]. J Hepatol, 2012, 56(2): 474-485. DOI: 10.1016/j.jhep.2011.07.004.
    [8]
    GENTIL MA, CASTRO DE LA NUEZ P, GONZALEZ-CORVILLO C, et al. Non-heart-beating donor kidney transplantation survival is similar to donation after brain death: comparative study with controls in a regional program[J]. Transplant Proc, 2016, 48(9): 2867-2870. DOI: 10.1016/j.transproceed.2016.07.036.
    [9]
    AITKEN E, COOPER C, DEMPSTER N, et al. Delayed graft function is a syndrome rather than a diagnosis[J]. Exp Clin Transplant, 2015, 13(1): 19-25.
    [10]
    薛武军, 田普训, 项和立, 等.心脏死亡器官捐献供肾移植单中心60例经验总结[J].中华器官移植杂志, 2013, 34(7): 387-391. DOI: 10.3760/cma.j.issn.0254-1785.2013.07.002.

    XUE WJ, TIAN PX, XIANG HL, et al. Donation after cardiac death (DCD) donor renal transplantation: a single center 60 cases of DCD experience[J]. Chin J Organ Transplant, 2013, 34(7): 387-391. DOI: 10.3760/cma.j.issn.0254-1785.2013.07.002.
    [11]
    NAGARAJA P, ROBERTS GW, STEPHENS M, et al. Impact of expanded criteria variables on outcomes of kidney transplantation from donors after cardiac death[J]. Transplantation, 2015, 99(1): 226-231. DOI: 10.1097/TP.0000000000000304.
    [12]
    SEO CH, JU JI, KIM MH, et al. Risk factors and long-term outcomes of delayed graft function in deceased donor renal transplantation[J]. Ann Surg Treat Res, 2015, 89(4): 208-214. DOI: 10.4174/astr.2015.89.4.208.
    [13]
    中华医学会器官移植学分会, 中国医师协会器官移植医师分会.中国公民逝世后器官捐献供肾体外低温机械灌注保存专家共识(2016版)[J/CD].中华移植杂志(电子版), 2016, 10(4): 154-158. DOI: 10.3877/cma.j.issn.1674-3903.2016.04.002.

    Branch of Organ Transplantation of Chinese Medical Association, Branch of Organ Transplant Physician of Chinese Medical Doctor Association. Expert consensus on cryopreservation in vitro of donor kidney from organ donation after Chinese citizens' death (2016 edition)[J/CD]. Chin J Transplant(Electr Vers), 2016, 10(4): 154-158. DOI: 10.3877/cma.j.issn.1674-3903.2016.04.002.
    [14]
    董建辉, 廖吉祥, 孙煦勇, 等.LifePort保存心脏死亡器官捐献供肾的临床研究[J].临床泌尿外科杂志, 2014, 29(8): 697-700. DOI: 10.13201/j.issn.1001-1420.2014.08.012.

    DONG JH, LIAO JX, SUN XY, et al. Clinical research of transporting kidney from donation after cardiac death by LifePort[J]. J Clin Urol, 2014, 29(8): 697-700. DOI: 10.13201/j.issn.1001-1420.2014.08.012.
    [15]
    LAM VW, LAURENCE JM, RICHARDSON AJ, et al. Hypothermic machine perfusion in deceased donor kidney transplantation: a systematic review[J]. J Surg Res, 2013, 180(1): 176-182. DOI: 10.1016/j.jss.2012.10.055.
    [16]
    GUARRERA JV, GOLDSTEIN MJ, SAMSTEIN B, et al. 'When good kidneys pump badly': outcomes of deceased donor renal allografts with poor pulsatile perfusion characteristics[J]. Transpl Int, 2010, 23(4): 444-446. DOI: 10.1111/j.1432-2277.2009.00970.x.
    [17]
    XIAOMING P, XIANG H, LINJUAN L, et al. Preliminary results of transplantation with kidneys donated after cardiac death: a path of hope for organ transplantation in China[J]. Nephrol Dial Transplant, 2015, 30(9): 1590-1596. DOI: 10.1093/ndt/gfv049.
    [18]
    张驌, 陈妍君, 王诚, 等.Lifeport与静态低温保存应用于器官捐献供肾保存效果的Meta分析[J].器官移植, 2016, 7(4): 268-274. DOI: 10.3969/j.issn.1674-7445.2016.04.004.

    ZHANG S, CHEN YJ, WANG C, et al. Meta analysis of the effect of Lifeport and static cold storage on donor kidney[J]. Organ Transplant, 2016, 7(4): 268-274. DOI: 10.3969/j.issn.1674-7445.2016.04.004.
    [19]
    MUELLER TF, SOLEZ K, MAS V. Assessment of kidney organ quality and prediction of outcome at time of transplantation[J]. Semin Immunopathol, 2011, 33(2): 185-199. DOI: 10.1007/s00281-011-0248-x.
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