Volume 8 Issue 6
Nov.  2017
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Article Navigation >  ORGAN TRANSPLANTATION  > 2017  >  8(6): 450-454, 471
Liu Rongqiang, Zhang Yingcai, Yao Jia, et al. Clinical efficacy of application of hepatitis B surface antigen-positive donor liver in liver transplantation[J]. ORGAN TRANSPLANTATION, 2017, 8(6): 450-454, 471. doi: 10.3969/j.issn.1674-7445.2017.06.008
Citation: Liu Rongqiang, Zhang Yingcai, Yao Jia, et al. Clinical efficacy of application of hepatitis B surface antigen-positive donor liver in liver transplantation[J]. ORGAN TRANSPLANTATION, 2017, 8(6): 450-454, 471. doi: 10.3969/j.issn.1674-7445.2017.06.008
shu

Clinical efficacy of application of hepatitis B surface antigen-positive donor liver in liver transplantation

doi: 10.3969/j.issn.1674-7445.2017.06.008

  • Department of Hepatic Surgery and Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China

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  • Corresponding author: Wang Guoying, Email: wanggy3@126.com
  • Received Date: 2017-09-10
    Available Online: 2021-01-19
  • Publish Date: 2017-11-15
    Abstract
  •   Objective  To evaluate the clinical efficacy of application of hepatitis B surface antigen (HBsAg)-positive donor liver in adult liver transplantation.  Methods  Clinical efficacy of 28 recipients with liver diseases induced by virus B hepatitis (hepatitis B) undergoing liver transplantation using HBsAg-positive donor liver from July 2012 to October 2015 was retrospectively analyzed. Clinical prognosis and postoperative complications of the recipients were summarized. The changing features of serum levels of HBsAg and hepatitis B virus (HBV) DNA was investigated.  Results  After liver transplantation, 28 recipients were orally administered with entecavir to prevent the recurrence of hepatitis B. During perioperative period, 2 recipients died from sepsis and acute heart failure. During postoperative follow-up, 2 cases died from the recurrence of hepatocellular carcinoma (liver cancer). The remaining 24 patients were followed up for 12-26 months. Throughout the follow-up, 24 recipients were positive for serum HBsAg. After treatment, the titre of HBV DNA was significantly declined to < 1×102 copies/mL at postoperative 12 months. No graft dysfunction induced by hepatitis B recurrence occurred in 24 recipients alive.  Conclusions  As a marginal donor liver, HBsAg-positive liver graft is safe for liver transplantation in the recipients with hepatitis B-related liver diseases. Postoperatively, anti-HBV treatment should be strengthened and intimate follow-up should be delivered.

     

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    • References(33)
  • [1]
    Vizzini G, Gruttadauria S, Volpes R, et al. Lamivudine monoprophylaxis for de novo HBV infection in HBsAg-negative recipients with HBcAb-positive liver grafts[J]. Clin Transplant, 2011, 25(1): E77-E81. DOI: 10.1111/j.1399-0012.2010.01329.x.
    [2]
    Bortoluzzi I, Gambato M, Albertoni L, et al. Use of grafts from anti-HBc-positive donors in liver transplantation: a 5-year, single-center experience[J]. Transplant Proc, 2013, 45(7): 2707-2710. DOI: 10.1016/j.transproceed.2013.07.049.
    [3]
    Dodson SF, Bonham CA, Geller DA, et al. Prevention of de novo hepatitis B infection in recipients of hepatic allografts from anti-HBc positive donors[J]. Transplantation, 1999, 68(7): 1058-1061. doi: 10.1097/00007890-199910150-00028
    [4]
    Rocha MB, Boin IF, Escanhoela CA, et al. Can the use of marginal liver donors change recipient survival rate?[J]. Transplant Proc, 2004, 36(4): 914-915. DOI: 10.1016/j.transproceed.2004.03.116.
    [5]
    Cholongitas E, Papatheodoridis GV, Burroughs AK. Liver grafts from anti-hepatitis B core positive donors:a systematic review[J]. J Hepatol, 2010, 52(2): 272-279. DOI: 10.1016/j.jhep.2009.11.009.
    [6]
    Chotiyaputta W, Pelletier SJ, Fontana RJ, et al. Long-term efficacy of nucleoside monotherapy in preventing HBV infection in HBsAg-negative recipients of anti-HBc-positive donor livers[J]. Hepatol Int, 2010, 4(4): 707-715. DOI: 10.1007/s12072-010-9188-0.
    [7]
    Afonso RC, Hidalgo R, Paes AT, et al. Impact of cumulative risk factors for expanded criteria donors on early survival after liver transplantation[J]. Transplant Proc, 2008, 40(3): 800-801. DOI: 10.1016/j.transproceed.2008.03.017.
    [8]
    Gruenberger T, Steininger R, Sautner T, et al. Influence of donor criteria on postoperative graft function after orthotopic liver transplantation[J]. Transpl Int, 1994, 7(Suppl 1): S672-S674. http://europepmc.org/abstract/med/11271336
    [9]
    Perrillo RP, Eason JD. The use of HBsAg-positive organ donors: far more than meets the eye?[J]. Liver Transpl, 2005, 11(8): 875-877. DOI: 10.1002/lt.20449.
    [10]
    Donataccio D, Roggen F, De Reyck C, et al. Use of anti-HBc positive allografts in adult liver transplantation: toward a safer way to expand the donor pool[J]. Transpl Int, 2006, 19(1): 38-43. DOI: 10.1111/j.1432-2277.2005.00225.x.
    [11]
    中华医学会器官移植学分会, 中华医学会肝病学分会.中国肝移植乙型肝炎防治指南(2016版)[J].临床肝胆病杂志, 2017, 33(2): 213-220. DOI: 10.3969/j.issn.1001-5256.2017.02.002.

    Branch of Organ Transplantation of Chinese Medical Association, Branch of Hepatology of Chinese Medical Association. The practice guideline on prophylaxis and treatment of hepatitis B for liver transplantation in China (2016 edition)[J]. J Clin Hepatol, 2017, 33(2): 213-220. DOI: 10.3969/j.issn.1001-5256.2017.02.002.
    [12]
    Féray C, Zignego AL, Samuel D, et al. Persistent hepatitis B virus infection of mononuclear blood cells without concomitant liver infection. the liver transplantation model[J]. Transplantation, 1990, 49(6): 1155-1158. doi: 10.1097/00007890-199006000-00025
    [13]
    Castells L, Vargas V, Rodríguez F, et al. Clinical impact and efficacy of lamivudine therapy in de novo hepatitis B infection after liver transplantation[J]. Liver Transpl, 2002, 8(10): 892-900. DOI: 10.1053/jlts.2002.35555.
    [14]
    Ueda Y, Marusawa H, Kaido T, et al. Efficacy and safety of prophylaxis with entecavir and hepatitis B immunoglobulin in preventing hepatitis B recurrence after living-donor liver transplantation[J]. Hepatol Res, 2013, 43(1): 67-71. DOI: 10.1111/j.1872-034X.2012.01020.x.
    [15]
    Katz LH, Paul M, Guy DG, et al. Prevention of recurrent hepatitis B virus infection after liver transplantation: hepatitis B immunoglobulin, antiviral drugs, or both? systematic review and Meta-analysis[J]. Transpl Infect Dis, 2010, 12(4): 292-308. DOI: 10.1111/j.1399-3062.2009.00470.x.
    [16]
    Saab S, Chang AJ, Comulada S, et al. Outcomes of hepatitis C-and hepatitis B core antibody-positive grafts in orthotopic liver transplantation[J]. Liver Transpl, 2003, 9(10): 1053-1061. DOI: 10.1053/jlts.2003.50208.
    [17]
    Stravitz RT, Shiffman ML, Kimmel M, et al. Substitution of tenofovir/emtricitabine for Hepatitis B immune globulin prevents recurrence of hepatitis B after liver transplantation[J]. Liver Int, 2012, 32(7): 1138-1145. DOI: 10.1111/j.1478-3231.2012.02770.x.
    [18]
    McGonigal KH, Bajjoka IE, Abouljoud MS. Tenofovir-emtricitabine therapy for the prevention of hepatitis B recurrence in four patients after liver transplantation[J]. Pharmacotherapy, 2013, 33(9): e170-e176. DOI: 10.1002/phar.1306.
    [19]
    Fung J, Cheung C, Chan SC, et al. Entecavir monotherapy is effective in suppressing hepatitis B virus after liver transplantation[J]. Gastroenterology, 2011, 141(4): 1212-1219. DOI: 10.1053/j.gastro.2011.06.083.
    [20]
    Fung J, Chan SC, Cheung C, et al. Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B[J]. Am J Gastroenterol, 2013, 108(6): 942-948. DOI: 10.1038/ajg.2013.111.
    [21]
    Fung J, Wong T, Chok K, et al. Long-term outcomes of entecavir monotherapy for chronic hepatitis B after liver transplantation:results up to 8 years[J]. Hepatology, 2017, 66(4): 1036-1044. DOI: 10.1002/hep.29191.
    [22]
    Hwang S, Lee SG, Park KM, et al. Five-year follow-up of a hepatitis B virus-positive recipient of hepatitis B surface antigen-positive living donor liver graft[J]. Liver Transpl, 2006, 12(6): 993-997. DOI: 10.1002/lt.20799.
    [23]
    Schemmer P, Nickkholgh A, Hinz U, et al. Extended donor criteria have no negative impact on early outcome after liver transplantation: a single-center multivariate analysis[J]. Transplant Proc, 2007, 39(2): 529-534. DOI: 10.1016/j.transproceed.2006.12.002.
    [24]
    中华医学会器官移植学分会, 中华医学会外科学分会移植学组, 中国医师协会器官移植医师分会, 等.中国肝癌肝移植临床实践指南[J/CD].中华危重症医学杂志(电子版), 2014, 7(6): 38-42. DOI: 10.3877/cma.j.issn.1674-6880.2014.06.009.

    Branch of Organ Transplantation of Chinese Medical Association, Transplantation Group of Surgery Branch of Chinese Medical Association, Organ Transplant Physicians Branch of Chinese Medical Doctor Association, et al. Clinical practice guideline of liver transplantation of liver cancer in China[J/CD]. Chin J Crit Care Med (Electr Edit), 2014, 7(6): 38-42. DOI: 10.3877/cma.j.issn.1674-6880.2014.06.009.
    [25]
    Huprikar S, Danziger-Isakov L, Ahn J, et al. Solid organ transplantation from hepatitis B virus-positive donors: consensus guidelines for recipient management[J]. Am J Transplant, 2015, 15(5): 1162-1172. DOI: 10.1111/ajt.13187.
    [26]
    Franchello A, Ghisetti V, Marzano A, et al. Transplantation of hepatitis B surface antigen-positive livers into hepatitis B virus-positive recipients and the role of hepatitis delta coinfection[J]. Liver Transpl, 2005, 11(8): 922-928. DOI: 10.1002/lt.20471.
    [27]
    Loggi E, Micco L, Ercolani G, et al. Liver transplantation from hepatitis B surface antigen positive donors: a safe way to expand the donor pool[J]. J Hepatol, 2012, 56(3): 579-585. DOI: 10.1016/j.jhep.2011.09.016.
    [28]
    Yu S, Yu J, Zhang W, et al. Safe use of liver grafts from hepatitis B surface antigen positive donors in liver transplantation[J]. J Hepatol, 2014, 61(4): 809-815. DOI: 10.1016/j.jhep.2014.05.003.
    [29]
    Krishnamoorthi R, Manickam P, Cappell MS. Liver transplantation of hepatitis B surface antigen positive donors to hepatitis B core antibody recipients: analysis of 27 patients[J]. Minerva Gastroenterol Dietol, 2014, 60(2): 113-118.
    [30]
    Jeng LB, Thorat A, Yang HR, et al. Successful use of hepatitis B surface antigen-positive liver grafts-an effective source for donor organs in endemic areas:a single-center experience[J]. Ann Transplant, 2015, 20: 103-111. DOI: 10.12659/AOT.893032.
    [31]
    Ballarin R, Cucchetti A, Russo FP, et al. Long term follow-up and outcome of liver transplantation from hepatitis B surface antigenpositive donors[J]. World J Gastroenterol, 2017, 23(12): 2095-2105. DOI: 10.3748/wjg.v23.i12.2095.
    [32]
    Li Z, Hu Z, Xiang J, et al. Use of hepatitis B surface antigen-positive grafts in liver transplantation: a matched analysis of the US National database[J]. Liver Transpl, 2014, 20(1): 35-45. DOI: 10.1002/lt.23774.
    [33]
    Saidi RF, Jabbour N, Shah SA, et al. Liver transplantation from hepatitis B surface antigen-positive donors[J]. Transplant Proc, 2013, 45(1): 279-280. DOI: 10.1016/j.transproceed.2012.05.077.
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