Volume 8 Issue 4
Jul.  2017
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Hao Qingchun, Zeng Qiang, Liu x Liu Baowang, et al. Successful pregnancy and delivery in a patient with Niemaoh-Pick disease after liver transplantation: report of one case and literature review[J]. ORGAN TRANSPLANTATION, 2017, 8(4): 304-307. doi: 10.3969/j.issn.1674-7445.2017.04.010
Citation: Hao Qingchun, Zeng Qiang, Liu x Liu Baowang, et al. Successful pregnancy and delivery in a patient with Niemaoh-Pick disease after liver transplantation: report of one case and literature review[J]. ORGAN TRANSPLANTATION, 2017, 8(4): 304-307. doi: 10.3969/j.issn.1674-7445.2017.04.010

Successful pregnancy and delivery in a patient with Niemaoh-Pick disease after liver transplantation: report of one case and literature review

doi: 10.3969/j.issn.1674-7445.2017.04.010
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  • Corresponding author: Dou Jian, Email: 2423978344@qq.com
  • Received Date: 2017-04-28
    Available Online: 2021-01-19
  • Publish Date: 2017-07-15
  •   Objective  To summarize the clinical experience of patient diagnosed with Niemaoh-Pick disease being pregnant after liver transplantation.  Methods  Clinical data of one case of type B Niemaoh-Pick disease being pregnant after liver transplantation were retrospectively analyzed.  Results  The patient successfully underwent liver transplantation combined with splenic artery ligation on July 8, 2011. She was well recovered postoperatively. After surgery, she received conventional anti-rejection treatment, and gradually switched to use of tacrolimus at a dosage of 2.5 mg/d. The serum drug concentration was maintained at 2 ng/mL. In September 2015, she was successfully pregnant. On June 2, 2016, she delivered a male infant through cesarean section. She could breastfeed the infant in a low quantity early after delivery. Both the mother and infant were followed up until submission date. The mother was physically stable and the infant grew normally.  Conclusions  Patients diagnosed with Niemaoh-Pick disease can obtain favorable clinical outcomes of pregnancy and delivery after liver transplantation.

     

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  • [1]
    Vanier MT. Biochemical studies in Niemann-Pick disease. Ⅰ. majorsphingolipids of liver and spleen[J]. Biochim Biophys Acta, 1983, 750(1): 178-184. doi: 10.1016/0005-2760(83)90218-7
    [2]
    Müssig K, Harzer K, Mayrhofer H, et al. Clinical findings in Niemann-Pick disease type B [J]. Intern Med J, 2006, 36(2): 135-136. DOI: 10.1111/j.1445-5994.2005.01013.x.
    [3]
    Jabiry-Zienjewicz Z, Kaminski P, Bobrowska K, et al. Menstrual cycle and sex hormone profile in perimenopausal women after liver transplantation [J]. Transplant Proc, 2006, 38(9): 2909-2912. DOI: 10.1016/j.transproceed.2006.08.114.
    [4]
    Spearman CW, Goddard E, McCulloch MI, et al. Pregnancy following liver transplantation during childhood and adolescence[J]. Pediatr Transplant, 2011, 15(7): 712-717. DOI: 10.1111/j.1399-3046.2011.01554.x.
    [5]
    Castañón Martínez R, Fernández-Velilla Peña M, González Montaño MV, et al. Lung affectation in an adult patient with Niemann-Pick disease, type B [J]. Arch Bronconeumol, 2012, 48(6): 213-215. DOI: 10.1016/j.arbres.2011.07.009.
    [6]
    Simpson WL Jr, Mendelson D, Wasserstein MP, et al. Imaging manifestations of Niemann-Pick disease type B [J]. AJR Am J Roentgenol, 2010, 194(1): W12-W19. DOI: 10.2214/AJR.09.2871.
    [7]
    Coscia LA, Constantinescu S, Moritz MJ, et al. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation[J]. Clin Transpl, 2009: 103-122. https://iths.pure.elsevier.com/en/publications/report-from-the-national-transplantation-pregnancy-registry-ntpr-
    [8]
    Jabiry-Zieniewicz Z, Szpotanska-Sikorska M, Pietrzak B, et al. Pregnancy outcomes among female recipients after liver transplantation: further experience[J]. Transplant Proc, 2011, 43(8): 3043-3047. DOI: 10.1016/j.transproceed.2011.08.070.
    [9]
    Revaux A, Bernuau J, Ceccaldi PF, et al. Liver transplantation and pregnancy[J]. Presse Med, 2010, 39(11): 1143-1149. DOI: 10.1016/j.lpm.2010.05.001.
    [10]
    Kim WR, Stock PG, Smith JM, et al. OPTN/SRTR 2011 Annual Data Report: liver[J]. Am J Transplant, 2013, 13(Suppl 1): 73-102. DOI: 10.1111/ajt.12021.
    [11]
    Alvaro E, Jimenez LC, Palomo I, et al. Pregnancy and orthotopic liver transplantation[J]. Transplant Proc, 2013, 45(5): 1966-1968. DOI: 10.1016/j.transproceed.2013.01.013.
    [12]
    Jabiry-Zieniewicz Z, Dabrowski FA, Pietrzak B, et al. Pregnancy complications after liver transplantation[J]. Int J Gynaecol Obstet, 2015, 128(1): 27-29. DOI: 10.1016/j.ijgo.2014.07.032.
    [13]
    Parhar KS, Gibson PS, Coffin CS.Pregnancy following liver transplantation: review of outcomes and recommendations for management[J]. Can J Gastroenterol, 2012, 26(9): 621-626. doi: 10.1155/2012/137129
    [14]
    López-Cepero R, de la Vega A, Lynch L. Pregnancy after liver transplantation[J]. Bol Asoc Med P R, 2013, 105(1): 9-13. http://europepmc.org/abstract/MED/23767378
    [15]
    Finnell RH. Teratology: general considerations and principles[J]. J Allergy Clin Immunol, 1999, 103(2 Pt 2):S337-S342. http://europepmc.org/abstract/MED/9949334
    [16]
    Jain A, Venkataramanan R, Fung JJ, et al. Pregnancy after liver transplantation under tacrolimus[J]. Transplantation, 1997, 64(4): 559-565. doi: 10.1097/00007890-199708270-00002
    [17]
    Jain AB, Reyes J, Marcos A, et al. Pregnancy after liver transplantation with tacrolimus immunosuppression: a single center' s experience update at 13 years[J]. Transplantation, 2003, 76(5): 827-832. DOI: 10.1097/01.TP.0000084823.89528.89.
    [18]
    Kainz A, Harabacz I, Cowlrick IS, et al. Analysis of 100 pregnancy outcomes in women treated systemically with tacrolimus[J]. Transpl Int, 2000, 13(Suppl 1): S299-S300. doi: 10.1007/s001470050347
    [19]
    Sifontis NM, Coscia LA, Constantinescu S, et al. Pregnancy outcomes in solid organ transplant recipients with exposure to mycophenolate mofetil or sirolimus[J]. Transplantation, 2006, 82(12): 1698-1702. DOI: 10.1097/01.tp.0000252683.74584.29.
    [20]
    Zheng S, Easterling TR, Hays K, et al. Tacrolimus placental transfer at delivery and neonatal exposure through breast milk[J]. Br J Clin Pharmacol, 2013, 76(6): 988-996. DOI: 10.1111/bcp.12122.
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