Volume 8 Issue 3
May  2017
Turn off MathJax
Article Contents
Article Navigation >  ORGAN TRANSPLANTATION  > 2017  >  8(3): 220-224
Mao Jiaxi, Zou You, Guo Wenyuan. Empirical treatment of nontuberculosis mycobacterium infection after liver transplantation: one case report and literature[J]. ORGAN TRANSPLANTATION, 2017, 8(3): 220-224. doi: 10.3969/j.issn.1674-7445.2017.03.009
Citation: Mao Jiaxi, Zou You, Guo Wenyuan. Empirical treatment of nontuberculosis mycobacterium infection after liver transplantation: one case report and literature[J]. ORGAN TRANSPLANTATION, 2017, 8(3): 220-224. doi: 10.3969/j.issn.1674-7445.2017.03.009
shu

Empirical treatment of nontuberculosis mycobacterium infection after liver transplantation: one case report and literature

doi: 10.3969/j.issn.1674-7445.2017.03.009

  • Department of Liver Transplantation, Changzheng Hospital of Second Military Medical University, Shanghai 200003, China

More Information
  • Corresponding author: Guo Wenyuan, Email: guowenyuan@medmail.com.cn
  • Received Date: 2017-02-10
    Available Online: 2021-01-19
  • Publish Date: 2017-05-15
    Abstract
  •   Objective   To summarize the clinical experience of diagnosis and treatment of nontuberculosis mycobacterium (NTM) infection after liver transplantation.   Methods   Clinical experience of effective treatment of 1 case with NTM at 7th month after liver transplantation at the Shanghai Changzheng Hospital affiliated to the Second Military Medical University was summarized and literature review was performed.   Results   Following liver transplantation, the NTM patient was clinically manifested with fever in the afternoon. CT scan prompted the progression of the disease. The lesions were enlarged and fused with thin-walled cavity in the right upper lung. The diagnosis of NTM infection was validated by fiberoptic bronchoscopy (brush or lavage approach), spot test of T cells infected with mycobacterium tuberculosis (T-SPOT.TB), multiple phlegm culture and empirical anti-tuberculosis therapy. The patient was effectively treated and successfully discharged after diagnostic quadruple anti-tuberculosis therapy. The patient was followed up until the day of manuscript submission. The patient was physically stable without the symptoms of fever and cough with asthma. The liver function was normal.   Conclusions   The incidence of NTM infection is rare and inneglectable after liver transplantation. Application of fibrobronchoscopy via brush or lavage approach can enhance the positive diagnostic rate. Diagnostic quadruple anti-tuberculosis therapy is efficacious for NTM infection.

     

    • FullText(HTML)
  • loading
    • References(10)
  • [1]
    Doucette K, Fishman JA. Nontuberculous mycobacterial infection in hematopoietic stem cell and solid organ transplant recipients[J]. Clin Infect Dis, 2004, 38(10):1428-1439. DOI: 10.1086/420746.
    [2]
    Longworth SA, Vinnard C, Lee I, et al. Risk factors for nontuberculous mycobacterial infections in solid organ transplant recipients: a case-control study[J]. Transpl Infect Dis, 2014, 16(1):76-83. DOI: 10.1111/tid.12170.
    [3]
    Maybrook RJ, Campsen J, Wachs ME, et al. A case of mycobacterium mucogenicum infection in a liver transplant recipient and a review of the literature[J]. Transpl Infect Dis, 2013, 15(6):E260-E263. DOI: 10.1111/tid.12154.
    [4]
    Singhal A, Gates C, Malhotra N, et al. Successful management of primary nontuberculous mycobacterial infection of hepatic allograft following orthotopic liver transplantation for hepatitis C[J]. Transpl Infect Dis, 2011, 13(1):47-51. DOI: 10.1111/j.1399-3062.2010.00521.x.
    [5]
    杨美芳, 俞海英, 吴炜, 等. 肝移植术后非结核分枝杆菌感染2例并文献复习[C]. 浙江省医学会结核病学分会第一届学术年会论文汇编, 2015: 183-185.

    Yang MF, Yu HY, Wu W, et al. Non tuberculous mycobacterial infection after liver transplantation: a report of 2 cases and literature review[C]. First Academic Conference Proceedings of Tuberculosis Section in Zhejiang Province Medical Association, 2015:183-185.
    [6]
    周先志.器官移植患者中非结核分枝杆菌的感染[J].传染病信息, 1994, 7(4):151. http://www.cnki.com.cn/Article/CJFDTOTAL-CRBX199404031.htm

    Zhou XZ. Infection of non tuberculous mycobacteria in organ transplant recipients[J]. Infect Dis Inform, 1994, 7(4):151. http://www.cnki.com.cn/Article/CJFDTOTAL-CRBX199404031.htm
    [7]
    Han YM, Kim HS, Kim CH, et al. Analysis of patients with positive acid-fast bacilli culture and negative T-SPOT. TB results[J]. Korean J Lab Med, 2010, 30(4):414-419. DOI: 10.3343/kjlm.2010.30.4.414.
    [8]
    段新亚. 48例非结核分枝杆菌肺病的临床分析[J].云南医药, 2016, 37(4): 445-447. http://cpfd.cnki.com.cn/Article/CPFDTOTAL-ZGFN201008001052.htm

    Duan XY. Clinical analysis of 48 cases with non tuberculous mycobacterial lung disease[J]. Med Pharm Yunnan, 2016, 37(4): 445-447. http://cpfd.cnki.com.cn/Article/CPFDTOTAL-ZGFN201008001052.htm
    [9]
    吴海峰, 张辉, 王艳彬, 等.非结核分枝杆菌快速药敏试验研究[J].医学动物防制, 2014, 30(6):591-593. DOI: 10.7629/yxdwfz201406001.

    Wu HF, Zhang H, Wang YB, et al. Rapid drug susceptibility experimental research on nontuberculosis mycobacteria[J]. J Med Pest Control, 2014, 30(6):591-593. DOI: 10.7629/yxdwfz201406001.
    [10]
    董波, 王冕.非结核分枝杆菌肺病与肺结核临床特征对比分析[J].现代实用医学, 2016, 28(4): 546-547. DOI: 10.3969/j.issn.1671-0800.2016.04.070.

    Dong B, Wang M. Comparative analysis of clinical features of pulmonary tuberculosis and non tuberculous mycobacterial lung disease[J]. Mod Pract Med, 2016, 28(4):546-547. DOI: 10.3969/j.issn.1671-0800.2016.04.070.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (218) PDF downloads(10) Cited by()
    Proportional views
    Related

    WeChat Subscription Account

    Wechat Service Account

    Contact Us
    • Tel：020-38736410
    • Email: organtranspl@163.com
    • Address：The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou
    • Editorial Office of Organ Transplantation  粤ICP备2021030844号
    Links

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return