Volume 7 Issue 5
Sep.  2016
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Yang Shaozhen, Zhou Lin, Du Guosheng, et al. Correlation of tumor recurrence after liver transplantation for hepatocellular carcinoma with the expression levels of regulatory T cells and cytokines in peripheral blood[J]. ORGAN TRANSPLANTATION, 2016, 7(5): 382-385. doi: 10.3969/j.issn.1674-7445.2016.05.010
Citation: Yang Shaozhen, Zhou Lin, Du Guosheng, et al. Correlation of tumor recurrence after liver transplantation for hepatocellular carcinoma with the expression levels of regulatory T cells and cytokines in peripheral blood[J]. ORGAN TRANSPLANTATION, 2016, 7(5): 382-385. doi: 10.3969/j.issn.1674-7445.2016.05.010
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Correlation of tumor recurrence after liver transplantation for hepatocellular carcinoma with the expression levels of regulatory T cells and cytokines in peripheral blood

doi: 10.3969/j.issn.1674-7445.2016.05.010

  • Hebei North University, Zhangjiakou 075000, China

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  • Corresponding author: Du Guosheng, Email：duguosheng@medmail.com.cn
  • Received Date: 2016-05-20
    Available Online: 2021-01-19
  • Publish Date: 2016-09-15
    Abstract
  •   Objective  To analyze the correlation of tumor recurrence after liver transplantation for hepatocellular carcinoma(HCC) with the expression levels of regulatory T cell(Treg) and cytokines in peripheral blood.  Methods  A total of 56 patients who underwent liver transplantation in the 309th Hospital of People's Liberation Army from 2010 to 2014 were studied. According to the postoperative pathological data, all the patients were divided into the group of liver transplantation for HCC (HCC group, n=28) and group of liver transplantation for cirrhosis (liver cirrhosis group, n=28), of which the HCC group was further divided into non-recurrence group (n=8) and recurrence group (n=20) according to the situation of postoperative tumor recurrence. The expression levels of Treg and cytokines [vascular endothelial growth factor (VEGF), interleukin (IL) -2, IL-10, IL-12, transformation growth factor (TGF) -β and interferon (IFN) -γ] in peripheral blood of the patients in various groups were compared.  Results  Compared with the liver cirrhosis group, levels of IFN-γ and IL-12 in the non-recurrence group increased significantly (both P < 0.05); levels of Treg%, VEGF, IFN-γ, IL-10 and TGF-β in the recurrence group increased significantly, while levels of IL-2 and IL-12 decreased significantly (all P < 0.05). Compared with the non-recurrence group, levels of Treg%, VEGF, IL-10 and TGF-β in the recurrence group increased significantly, while levels of IFN-γ, IL-2 and IL-12 decreased significantly (all P < 0.05).  Conclusions  Levels of Treg and cytokines can be used to predict the tumor recurrence after liver transplantation for HCC.

     

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    • References(18)
  • [1]
    Ozgur HH, Ercetin AP, Eliyatkin N, et al. Regulatory T cells and their prognostic value in hepatopancreatobiliary tumours[J]. Hepatogastroenterology, 2014, 61(135):1847-1851. http://cn.bing.com/academic/profile?id=2334970166&encoded=0&v=paper_preview&mkt=zh-cn
    [2]
    Chen X, Du Y, Huang Z.CD4+CD25+Treg derived from hepatocellular carcinoma mice inhibits tumor immunity[J]. Immunol Lett, 2012, 148(1):83-89. doi: 10.1016/j.imlet.2012.09.002
    [3]
    Ligocki AJ, Niederkorn JY. Advances on non-CD4+Foxp3+ T regulatory cells: CD8+, type 1, and double negative T regulatory cells in organ transplantation[J]. Transplantation, 2015, 99(8):1553-1559. doi: 10.1097/TP.0000000000000813
    [4]
    杜国盛, 周林, 石炳毅, 等.三联抗肿瘤疗法预防晚期原发性肝癌肝移植术后肿瘤复发的临床研究[J].器官移植, 2014, 5(2):74-77. http://www.organtranspl.com/browse/detail/qkid/85/id/221.html

    Du GS, Zhou L, Shi BY, et al. Clinical study of triple anti-tumor therapy for preventing tumor recurrence of terminal primary liver cancer after liver transplantation[J]. Organ Transplant, 2014, 5(2):74-77. http://www.organtranspl.com/browse/detail/qkid/85/id/221.html
    [5]
    杜国盛, 周林, 朱志东, 等. Foxp3+调节性T细胞与肝癌肝移植患者术后肿瘤复发关系的研究[J].器官移植, 2015, 6(5):310-315. http://www.organtranspl.com/browse/detail/cat/33/id/125

    Du GS, Zhou L, Zhu ZD, et al. Research on the relationship between Foxp3+ regulatory T cell and tumor recurrence of patients after liver transplantation for hepatocellular carcinoma[J]. Organ Transplant, 2015, 6(5):310-315. http://www.organtranspl.com/browse/detail/cat/33/id/125
    [6]
    Chen X, Du Y, Lin X, et al. CD4+CD25+ regulatory T cells in tumor immunity[J]. Int Immunopharmacol, 2016, 34:244-249. doi: 10.1016/j.intimp.2016.03.009
    [7]
    Teh PP, Vasanthakumar A, Kallies A, et al. Development and function of effector regulatory T cells[J]. Prog Mol Biol Transl Sci, 2015, 136:155-174. doi: 10.1016/bs.pmbts.2015.08.005
    [8]
    Akdis CA, Akdis M. Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens[J]. World Allergy Organ J, 2015, 8(1):17. doi: 10.1186/s40413-015-0063-2
    [9]
    Hall BM. T cells: soldiers and spies-the surveillance and control of effector T cells by regulatory T cells[J]. Clin J Am Soc Nephrol, 2015, 10(11):2050-2064. doi: 10.2215/CJN.06620714
    [10]
    Li L, Yang C, Zhao Z, et al. Skewed T-helper (Th) 1/2-and Th17/T regulatory cell balances in patients with renal cell carcinoma[J]. Mol Med Rep, 2015, 11(2):947-953. http://www.sigmaaldrich.com/catalog/papers/25352158
    [11]
    Askar M. T helper subsets & regulatory T cells: rethinking the paradigm in the clinical context of solid organtransplantation[J]. Int J Immunogenet, 2014, 41(3):185-194. doi: 10.1111/iji.2014.41.issue-3
    [12]
    Liu KS, Fan XQ, Zhang L, et al. Effects of recombinant human interleukin-10 on Treg cells, IL-10 and TGF-β in transplantation of rabbit skin[J]. Mol Med Rep, 2014, 9(2):639-644. http://www.medscape.com/medline/abstract/24270972
    [13]
    Metidji A, Rieder SA, Glass DD, et al. IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions[J]. J Immunol, 2015, 194(9):4265-4276. doi: 10.4049/jimmunol.1500036
    [14]
    Vahl JC, Drees C, Heger K, et al. Continuous T cell receptor signals maintain a functional regulatory T cell pool[J]. Immunity, 2014, 41(5):722-736. doi: 10.1016/j.immuni.2014.10.012
    [15]
    Zhao Y, Wu T, Shao S, et al. Phenotype, development, and biological function of myeloid-derived suppressor cells[J]. Oncoimmunology, 2015, 5(2):e1004983. https://www.ncbi.nlm.nih.gov/pubmed/27057424
    [16]
    Wang Y, Liu T, Tang W, et al. Hepatocellular carcinoma cells induce regulatory T Cells and lead to poor prognosis via production of transforming growth factor-β1[J]. Cell Physiol Biochem, 2016, 38(1):306-318. doi: 10.1159/000438631
    [17]
    Pandiyan P, Zhu J. Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells[J]. Cytokine, 2015, 76(1):13-24. doi: 10.1016/j.cyto.2015.07.005
    [18]
    张志强, 贺杰峰, 张瑜, 等.大鼠肝癌免疫微环境中Treg与IL-10水平的变化及意义[J].当代医学, 2014, 20(4):18-19. http://mall.cnki.net/magazine/article/ddyi201404011.htm

    Zhang ZQ, He JF, Zhang Y, et al. The change and significance of the levels of Treg and IL-10 in immune microenvironment of rat with liver cancer[J]. Contemp Med, 2014, 20(4):18-19. http://mall.cnki.net/magazine/article/ddyi201404011.htm
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