Volume 7 Issue 5
Sep.  2016
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Article Navigation >  ORGAN TRANSPLANTATION  > 2016  >  7(5): 370-377
Dong Hongmeng, Dai Yang, Zhang Xinxue, et al. Meta analysis of therapeutic effects on patients with ABO-incompatibility liver transplantation[J]. ORGAN TRANSPLANTATION, 2016, 7(5): 370-377. doi: 10.3969/j.issn.1674-7445.2016.05.008
Citation: Dong Hongmeng, Dai Yang, Zhang Xinxue, et al. Meta analysis of therapeutic effects on patients with ABO-incompatibility liver transplantation[J]. ORGAN TRANSPLANTATION, 2016, 7(5): 370-377. doi: 10.3969/j.issn.1674-7445.2016.05.008
shu

Meta analysis of therapeutic effects on patients with ABO-incompatibility liver transplantation

doi: 10.3969/j.issn.1674-7445.2016.05.008

  • Department of Hepatobiliary-pancreatic-spleen Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

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    Abstract
  •   Objective  To systematic evaluation the therapeutic effects on patients with ABO-incompatibility liver transplantation (ILT), and compare the curative effect with ABO-compatible liver transplantation (CLT).  Methods  The literatures of comparison in clinical efficacy between ILT and CLT were collected at home and abroad by computer search in PubMed database, Embase database, Cochrane database, Medline database, Web of science database, CNKI, Wanfang database, VIP database, et al, and the quality of literatures were accessed. Meta analysis was carried out by fixed effect model and random effect model with RevMan5.3 software.  Results  A total of 18 papers were included. The results of Meta analysis showed that there was no significant difference in the survival rates of recipient between ILT group and CLT group at 1, 3 and 5 years after operation (all P > 0.05). Compared with CLT group, the survival rates of grafts were significantly decreased in ILT group at 1, 3 and 5 years after operation, and the difference was statistically significant (all P < 0.05). The incidences of postoperative biliary complication and acute rejection in ILT group were significantly higher than those in CLT group, the difference was statistically significant (both P < 0.05).  Conclusions  Compared with CLT, the curative effect of ILT is weaker but still can be used as a new choice for critical condition of the recipient or waiting for the donor liver for a long time.

     

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